IMP

Process View

Homo sapiens

1 genes annotated in human

kinin cascade

A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "kinin cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "kinin cascade" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	1.000
PLAUR	plasminogen activator, urokinase receptor	1.000
PLAT	plasminogen activator, tissue	0.986	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.983
PLAU	plasminogen activator, urokinase	0.969	Human
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.856
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.734
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.506
KNG1	kininogen 1	0.303
IL8	interleukin 8	0.259
TNC	tenascin C	0.246
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.234
NPC2	Niemann-Pick disease, type C2	0.215
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.192
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.182
SPHK1	sphingosine kinase 1	0.153
ORM1	orosomucoid 1	0.103
PLG	plasminogen	0.102	Human
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.095
C8A	complement component 8, alpha polypeptide	0.085
FOSL1	FOS-like antigen 1	0.084
EMP1	epithelial membrane protein 1	0.080
FGB	fibrinogen beta chain	0.077
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.075
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.073
VTN	vitronectin	0.072
GCGR	glucagon receptor	0.063
ITIH2	inter-alpha (globulin) inhibitor H2	0.056
RDH16	retinol dehydrogenase 16 (all-trans)	0.051
LPA	lipoprotein, Lp(a)	0.051	Human
AMT	aminomethyltransferase	0.051
PDGFC	platelet derived growth factor C	0.051
C9	complement component 9	0.050
MASP2	mannan-binding lectin serine peptidase 2	0.050
GCKR	glucokinase (hexokinase 4) regulator	0.048
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.043
INHBA	inhibin, beta A	0.042
THBS1	thrombospondin 1	0.042
SPP2	secreted phosphoprotein 2, 24kDa	0.042
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.042
CRP	C-reactive protein, pentraxin-related	0.041
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.041
CPN1	carboxypeptidase N, polypeptide 1	0.041
TIMP1	TIMP metallopeptidase inhibitor 1	0.040
TFR2	transferrin receptor 2	0.040
APOB	apolipoprotein B (including Ag(x) antigen)	0.039
BHMT	betaine--homocysteine S-methyltransferase	0.038
ITIH1	inter-alpha (globulin) inhibitor H1	0.038
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.037
C4BPB	complement component 4 binding protein, beta	0.035
F2	coagulation factor II (thrombin)	0.034
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.034
OSMR	oncostatin M receptor	0.031
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.030
FTCD	formiminotransferase cyclodeaminase	0.030
SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	0.029
ALDOB	aldolase B, fructose-bisphosphate	0.029
ANGPTL4	angiopoietin-like 4	0.027
LIPC	lipase, hepatic	0.027
HPX	hemopexin	0.026
APOF	apolipoprotein F	0.026
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.026
SAA4	serum amyloid A4, constitutive	0.026
F11	coagulation factor XI	0.025
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.024
PRODH2	proline dehydrogenase (oxidase) 2	0.024
AGXT	alanine-glyoxylate aminotransferase	0.024
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.023
GJB1	gap junction protein, beta 1, 32kDa	0.022
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.022
S100A2	S100 calcium binding protein A2	0.021
HNF4A	hepatocyte nuclear factor 4, alpha	0.020
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.020
CXCL3	chemokine (C-X-C motif) ligand 3	0.020
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.019
PVR	poliovirus receptor	0.019
TUBB6	tubulin, beta 6	0.019
ECM1	extracellular matrix protein 1	0.019
IL1B	interleukin 1, beta	0.018
C8B	complement component 8, beta polypeptide	0.018
EPHA2	EPH receptor A2	0.018
RANBP9	RAN binding protein 9	0.017
CD44	CD44 molecule (Indian blood group)	0.017
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.017
ITIH3	inter-alpha (globulin) inhibitor H3	0.016
HABP2	hyaluronan binding protein 2	0.016	Human
F10	coagulation factor X	0.016
TTR	transthyretin	0.016
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.015
CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	0.015
AMBP	alpha-1-microglobulin/bikunin precursor	0.015
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.015
PDLIM4	PDZ and LIM domain 4	0.015
FAP	fibroblast activation protein, alpha	0.015
CPB2	carboxypeptidase B2 (plasma)	0.015
CYR61	cysteine-rich, angiogenic inducer, 61	0.014
LTA4H	leukotriene A4 hydrolase	0.014
PROCR	protein C receptor, endothelial	0.014
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.013
RAB17	RAB17, member RAS oncogene family	0.013
FGA	fibrinogen alpha chain	0.013
ICAM1	intercellular adhesion molecule 1	0.013
LAMB3	laminin, beta 3	0.013
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.013
ALB	albumin	0.013
LRP1	low density lipoprotein receptor-related protein 1	0.013
C8G	complement component 8, gamma polypeptide	0.012
PON3	paraoxonase 3	0.012
CCL2	chemokine (C-C motif) ligand 2	0.012
HRG	histidine-rich glycoprotein	0.012
TMEM158	transmembrane protein 158 (gene/pseudogene)	0.012
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.012
TM4SF5	transmembrane 4 L six family member 5	0.012
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.012
APCS	amyloid P component, serum	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
SLC38A3	solute carrier family 38, member 3	0.012
FN1	fibronectin 1	0.011
SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	0.011
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.011
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.011
CCL20	chemokine (C-C motif) ligand 20	0.011
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.011
VEGFC	vascular endothelial growth factor C	0.011
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.011
NRP2	neuropilin 2	0.010
LGALS4	lectin, galactoside-binding, soluble, 4	0.010
RAB26	RAB26, member RAS oncogene family	0.010
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.010
EHD4	EH-domain containing 4	0.010
C6	complement component 6	0.010
HEXB	hexosaminidase B (beta polypeptide)	0.010