IMP

Process View

Homo sapiens

4 genes annotated in human

positive regulation of fibrinolysis

GO:0051919

Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of fibrinolysis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of fibrinolysis" (in gray)

Name	Description	Probability	Func Analog Organism
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	1.000
PLAUR	plasminogen activator, urokinase receptor	1.000
KNG1	kininogen 1	0.992
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.990
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.848
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.816
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.620
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.413
PLG	plasminogen	0.395
C8A	complement component 8, alpha polypeptide	0.338
C8B	complement component 8, beta polypeptide	0.311
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.301
VTN	vitronectin	0.289
CPN1	carboxypeptidase N, polypeptide 1	0.238
ORM1	orosomucoid 1	0.209
MASP2	mannan-binding lectin serine peptidase 2	0.197
FGB	fibrinogen beta chain	0.194
GCGR	glucagon receptor	0.162
LPA	lipoprotein, Lp(a)	0.149	Human
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.146
SPP2	secreted phosphoprotein 2, 24kDa	0.145
HPX	hemopexin	0.138
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.130
SAA4	serum amyloid A4, constitutive	0.111
SPHK1	sphingosine kinase 1	0.109
TNC	tenascin C	0.107
IL8	interleukin 8	0.103
HRG	histidine-rich glycoprotein	0.102
APOB	apolipoprotein B (including Ag(x) antigen)	0.099
APOC3	apolipoprotein C-III	0.097
RDH16	retinol dehydrogenase 16 (all-trans)	0.095
TAT	tyrosine aminotransferase	0.093
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.091
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.091
F2	coagulation factor II (thrombin)	0.091
ADH6	alcohol dehydrogenase 6 (class V)	0.084
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.081
APCS	amyloid P component, serum	0.079
TFR2	transferrin receptor 2	0.077
GCKR	glucokinase (hexokinase 4) regulator	0.076
C8G	complement component 8, gamma polypeptide	0.076
CRP	C-reactive protein, pentraxin-related	0.076
AMT	aminomethyltransferase	0.068
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.066
C6	complement component 6	0.065
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.063
PRODH2	proline dehydrogenase (oxidase) 2	0.059
ICAM1	intercellular adhesion molecule 1	0.054
ALDOB	aldolase B, fructose-bisphosphate	0.053
C4BPB	complement component 4 binding protein, beta	0.053
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.053
C9	complement component 9	0.052
LIPC	lipase, hepatic	0.052
FOSL1	FOS-like antigen 1	0.052
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.051
EMP1	epithelial membrane protein 1	0.050
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.050
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.048
APOF	apolipoprotein F	0.048
THBS1	thrombospondin 1	0.046
CTGF	connective tissue growth factor	0.045
AFM	afamin	0.044
AMBP	alpha-1-microglobulin/bikunin precursor	0.044
INHBA	inhibin, beta A	0.042
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.041
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.040
COL4A1	collagen, type IV, alpha 1	0.039
F10	coagulation factor X	0.039
AGXT	alanine-glyoxylate aminotransferase	0.038
BHMT	betaine--homocysteine S-methyltransferase	0.038
SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	0.037
FTCD	formiminotransferase cyclodeaminase	0.035
CPB2	carboxypeptidase B2 (plasma)	0.035
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.034
SLC38A3	solute carrier family 38, member 3	0.033
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.033
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.033
ITIH2	inter-alpha (globulin) inhibitor H2	0.032
ITIH1	inter-alpha (globulin) inhibitor H1	0.032
TM4SF1	transmembrane 4 L six family member 1	0.032
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.032
AHSG	alpha-2-HS-glycoprotein	0.031
OSMR	oncostatin M receptor	0.030
PDGFC	platelet derived growth factor C	0.030
ITIH3	inter-alpha (globulin) inhibitor H3	0.030
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.028
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.027
PXDN	peroxidasin homolog (Drosophila)	0.025
HNF4A	hepatocyte nuclear factor 4, alpha	0.023
FGA	fibrinogen alpha chain	0.023
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.023
ARG1	arginase, liver	0.022
F11	coagulation factor XI	0.022
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.022
FGG	fibrinogen gamma chain	0.022
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.022
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.022
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.021
TIMP1	TIMP metallopeptidase inhibitor 1	0.021
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.021
FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	0.020
FAP	fibroblast activation protein, alpha	0.020
CFHR2	complement factor H-related 2	0.019
VEGFC	vascular endothelial growth factor C	0.019
GYS2	glycogen synthase 2 (liver)	0.019
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.019
ANGPTL4	angiopoietin-like 4	0.019
CD44	CD44 molecule (Indian blood group)	0.019
HAS2	hyaluronan synthase 2	0.019
DPYS	dihydropyrimidinase	0.018
PTRF	polymerase I and transcript release factor	0.018
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.018
ALB	albumin	0.018
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.018
PVR	poliovirus receptor	0.018
PON3	paraoxonase 3	0.017
SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	0.017
COL6A3	collagen, type VI, alpha 3	0.017
ALDH1A3	aldehyde dehydrogenase 1 family, member A3	0.017
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.017
APOA2	apolipoprotein A-II	0.017
TTR	transthyretin	0.016
LOX	lysyl oxidase	0.016
CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	0.016
ECM1	extracellular matrix protein 1	0.016
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.016
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.016
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.016
PROCR	protein C receptor, endothelial	0.016
HPD	4-hydroxyphenylpyruvate dioxygenase	0.016
NNMT	nicotinamide N-methyltransferase	0.015
IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	0.015
F9	coagulation factor IX	0.015
TMEM158	transmembrane protein 158 (gene/pseudogene)	0.015
TUBB6	tubulin, beta 6	0.015
HPN	hepsin	0.015
NRP2	neuropilin 2	0.014
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.014
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.014
HRH1	histamine receptor H1	0.014
IER3	immediate early response 3	0.014
PDLIM4	PDZ and LIM domain 4	0.014
FST	follistatin	0.013
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.013
FGL1	fibrinogen-like 1	0.013
MFAP2	microfibrillar-associated protein 2	0.013
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.013
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.013
IGFBP3	insulin-like growth factor binding protein 3	0.013
ASGR2	asialoglycoprotein receptor 2	0.013
GLS2	glutaminase 2 (liver, mitochondrial)	0.013
OTC	ornithine carbamoyltransferase	0.013
HBEGF	heparin-binding EGF-like growth factor	0.013
FN1	fibronectin 1	0.013
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.013
GNMT	glycine N-methyltransferase	0.013
FABP1	fatty acid binding protein 1, liver	0.012
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.012
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.012
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.012
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.012
LAMB3	laminin, beta 3	0.012
PIGR	polymeric immunoglobulin receptor	0.012
SHBG	sex hormone-binding globulin	0.012
STC1	stanniocalcin 1	0.012
C4BPA	complement component 4 binding protein, alpha	0.012
IGFBP1	insulin-like growth factor binding protein 1	0.012
EPHA2	EPH receptor A2	0.012
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.012
SRPX	sushi-repeat containing protein, X-linked	0.011
APOM	apolipoprotein M	0.011
CPN2	carboxypeptidase N, polypeptide 2	0.011
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.011
PKLR	pyruvate kinase, liver and RBC	0.011
ECHDC2	enoyl CoA hydratase domain containing 2	0.011
RAB17	RAB17, member RAS oncogene family	0.011
EHD4	EH-domain containing 4	0.011
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.011
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
TFPI2	tissue factor pathway inhibitor 2	0.010
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.010
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.010
CXCL3	chemokine (C-X-C motif) ligand 3	0.010
MBL2	mannose-binding lectin (protein C) 2, soluble	0.010