IMP
Process View
Homo sapiens
17 genes annotated in human
age related macular degeneration
DOID:10871
A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "age related macular degeneration"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CFH | complement factor H | 0.969 | ||
| C3 | complement component 3 | 0.779 | ||
| XAB2 | XPA binding protein 2 | 0.422 | ||
| LOXL1 | lysyl oxidase-like 1 | 0.421 | ||
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.372 | ||
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.357 | ||
| LY96 | lymphocyte antigen 96 | 0.302 | ||
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.299 | ||
| CFHR1 | complement factor H-related 1 | 0.231 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 0.223 | ||
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.170 | Human | |
| C1S | complement component 1, s subcomponent | 0.132 | ||
| ERCC8 | excision repair cross-complementing rodent repair deficiency, complementation group 8 | 0.106 | ||
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.079 | ||
| CFI | complement factor I | 0.074 | ||
| FCGRT | Fc fragment of IgG, receptor, transporter, alpha | 0.060 | ||
| LOX | lysyl oxidase | 0.045 | ||
| FBN1 | fibrillin 1 | 0.045 | ||
| EFEMP2 | EGF containing fibulin-like extracellular matrix protein 2 | 0.035 | Human | |
| PSAP | prosaposin | 0.032 | ||
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.030 | Human | |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.026 | ||
| NPC2 | Niemann-Pick disease, type C2 | 0.026 | ||
| ISY1 | ISY1 splicing factor homolog (S. cerevisiae) | 0.025 | ||
| CFHR2 | complement factor H-related 2 | 0.023 | Human | |
| FN1 | fibronectin 1 | 0.021 | ||
| CFB | complement factor B | 0.019 | ||
| CFD | complement factor D (adipsin) | 0.018 | ||
| CD81 | CD81 molecule | 0.018 | ||
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.017 | ||
| RNF11 | ring finger protein 11 | 0.015 | ||
| XPA | xeroderma pigmentosum, complementation group A | 0.014 | ||
| IL1R1 | interleukin 1 receptor, type I | 0.013 | ||
| CLU | clusterin | 0.012 | ||
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.012 | ||
| CTSB | cathepsin B | 0.011 | ||
| CTSD | cathepsin D | 0.011 | ||
| DCN | decorin | 0.010 | ||
| HTRA1 | HtrA serine peptidase 1 | 0.005 | ||
| FBLN5 | fibulin 5 | 0.005 | ||
| ELOVL4 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 | 0.003 | ||
| CFHR3 | complement factor H-related 3 | 0.003 | ||
| HMCN1 | hemicentin 1 | 0.003 | ||
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.003 | ||
| ABCA4 | ATP-binding cassette, sub-family A (ABC1), member 4 | 0.003 | ||
| PROM1 | prominin 1 | 0.002 | ||
| TLR4 | toll-like receptor 4 | 0.002 | ||
| RAX2 | retina and anterior neural fold homeobox 2 | 0.002 | ||
| CNGB3 | cyclic nucleotide gated channel beta 3 | 0.001 | ||
| ERCC6 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | 0.001 | ||
| CST3 | cystatin C | 0.001 | ||
| ARMS2 | age-related maculopathy susceptibility 2 | 0.000 |