IMP

Process View

Homo sapiens

4 genes annotated in human

linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "linoleic acid metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "linoleic acid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
COTL1	coactosin-like 1 (Dictyostelium)	1.000
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.946
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.275
OTC	ornithine carbamoyltransferase	0.157
KRT5	keratin 5	0.155
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.139	Human
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.138
ADH6	alcohol dehydrogenase 6 (class V)	0.124
ALOXE3	arachidonate lipoxygenase 3	0.097
TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	0.095
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.093	Human
C6	complement component 6	0.086
MAT1A	methionine adenosyltransferase I, alpha	0.083
MAST1	microtubule associated serine/threonine kinase 1	0.077
LAMC3	laminin, gamma 3	0.075
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.069
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.066
C8B	complement component 8, beta polypeptide	0.063
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.063
GLYAT	glycine-N-acyltransferase	0.052
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.052
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.049
GSTA3	glutathione S-transferase alpha 3	0.046
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.045
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.044	Human
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.044	Human
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.044
AADAC	arylacetamide deacetylase (esterase)	0.043
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.042	Human
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.041
RIT1	Ras-like without CAAX 1	0.040
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.040
AGXT2	alanine--glyoxylate aminotransferase 2	0.040
HRG	histidine-rich glycoprotein	0.038
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.038
ALDOB	aldolase B, fructose-bisphosphate	0.038
KLK13	kallikrein-related peptidase 13	0.037
FMO4	flavin containing monooxygenase 4	0.037
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.036	Human
BHMT	betaine--homocysteine S-methyltransferase	0.035
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.032
CFHR4	complement factor H-related 4	0.031
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.031
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.031
FETUB	fetuin B	0.030
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.029
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.028	Human Mouse
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.027
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.027
HBP1	HMG-box transcription factor 1	0.027
HAL	histidine ammonia-lyase	0.027
MTTP	microsomal triglyceride transfer protein	0.026
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.026
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.025
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.025
C4BPA	complement component 4 binding protein, alpha	0.025
F9	coagulation factor IX	0.024
ACRV1	acrosomal vesicle protein 1	0.023
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.023	Human
MUC3A	mucin 3A, cell surface associated	0.023
AFM	afamin	0.023
DYNLT3	dynein, light chain, Tctex-type 3	0.022
TBC1D23	TBC1 domain family, member 23	0.022
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.022
G6PC	glucose-6-phosphatase, catalytic subunit	0.022
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.022
RNF32	ring finger protein 32	0.021
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.021	Human
XDH	xanthine dehydrogenase	0.021
IFRD1	interferon-related developmental regulator 1	0.020
HPX	hemopexin	0.019
F11	coagulation factor XI	0.019
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.019
CCL16	chemokine (C-C motif) ligand 16	0.019
SGK2	serum/glucocorticoid regulated kinase 2	0.018
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.018
ANXA10	annexin A10	0.018
GYS2	glycogen synthase 2 (liver)	0.018
F13B	coagulation factor XIII, B polypeptide	0.018
JHDM1D	jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)	0.018
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.018
PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	0.017
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.017
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.017
DPYS	dihydropyrimidinase	0.017
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.017
HGD	homogentisate 1,2-dioxygenase	0.017
CA5A	carbonic anhydrase VA, mitochondrial	0.016
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.016
CNGA1	cyclic nucleotide gated channel alpha 1	0.016
HABP2	hyaluronan binding protein 2	0.016
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.016
HPD	4-hydroxyphenylpyruvate dioxygenase	0.016
KRT4	keratin 4	0.016
FABP1	fatty acid binding protein 1, liver	0.016
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.016
MEP1B	meprin A, beta	0.016
TTPA	tocopherol (alpha) transfer protein	0.016
DUOX2	dual oxidase 2	0.016
C8A	complement component 8, alpha polypeptide	0.016
RDH16	retinol dehydrogenase 16 (all-trans)	0.015
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.015
A1CF	APOBEC1 complementation factor	0.015
DAO	D-amino-acid oxidase	0.015
CRP	C-reactive protein, pentraxin-related	0.015
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.015
CD5L	CD5 molecule-like	0.015
APOE	apolipoprotein E	0.015
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.015
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.014
A2M	alpha-2-macroglobulin	0.014
TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.014
ARG1	arginase, liver	0.014
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.014
DNASE1L3	deoxyribonuclease I-like 3	0.014
PNLIPRP1	pancreatic lipase-related protein 1	0.014
CIDEB	cell death-inducing DFFA-like effector b	0.014
LTC4S	leukotriene C4 synthase	0.014
C16orf72	chromosome 16 open reading frame 72	0.014
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.014
CPB2	carboxypeptidase B2 (plasma)	0.014
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.014
APOC4	apolipoprotein C-IV	0.014
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.013
RAB3D	RAB3D, member RAS oncogene family	0.013
GNMT	glycine N-methyltransferase	0.013
SLURP1	secreted LY6/PLAUR domain containing 1	0.013
TEC	tec protein tyrosine kinase	0.013
ATP10B	ATPase, class V, type 10B	0.013
TAT	tyrosine aminotransferase	0.013
LPA	lipoprotein, Lp(a)	0.013
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.013
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.013
COLEC10	collectin sub-family member 10 (C-type lectin)	0.013
PON3	paraoxonase 3	0.013
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.013
ADRA1A	adrenergic, alpha-1A-, receptor	0.013
LECT2	leukocyte cell-derived chemotaxin 2	0.013
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.013
ZNF295	zinc finger protein 295	0.013
KNG1	kininogen 1	0.013
YPEL5	yippee-like 5 (Drosophila)	0.012
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.012
PAX9	paired box 9	0.012
HP	haptoglobin	0.012
PON1	paraoxonase 1	0.012
PIPOX	pipecolic acid oxidase	0.012
PZP	pregnancy-zone protein	0.012
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.012
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.012
TM4SF4	transmembrane 4 L six family member 4	0.012
C9	complement component 9	0.012
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.012
PLG	plasminogen	0.012
ITIH2	inter-alpha (globulin) inhibitor H2	0.012
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.012
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.012
LRRC31	leucine rich repeat containing 31	0.012
CES3	carboxylesterase 3	0.012
SLC30A10	solute carrier family 30, member 10	0.012
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.011
RFPL3	ret finger protein-like 3	0.011
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.011
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.011
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.011
GJB5	gap junction protein, beta 5, 31.1kDa	0.011
C9orf68	chromosome 9 open reading frame 68	0.011
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.011
LY6G6C	lymphocyte antigen 6 complex, locus G6C	0.011
PAH	phenylalanine hydroxylase	0.011
RORC	RAR-related orphan receptor C	0.011
PADI3	peptidyl arginine deiminase, type III	0.011
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.010
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.010
TMPRSS11D	transmembrane protease, serine 11D	0.010
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.010
LTB4R2	leukotriene B4 receptor 2	0.010
VPS37A	vacuolar protein sorting 37 homolog A (S. cerevisiae)	0.010
SAA4	serum amyloid A4, constitutive	0.010
FBXO33	F-box protein 33	0.010
LYSMD3	LysM, putative peptidoglycan-binding, domain containing 3	0.010
TUT1	terminal uridylyl transferase 1, U6 snRNA-specific	0.010
UPK1B	uroplakin 1B	0.010
SLC7A9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.010
CLCA4	chloride channel accessory 4	0.010
UFM1	ubiquitin-fold modifier 1	0.010
ALOX12	arachidonate 12-lipoxygenase	0.010
LMNA	lamin A/C	0.010