Homo sapiens

545 known processes

APOE

apolipoprotein E

(Aliases: LPG,AD2,MGC1571,LDLCQ5)

APOE biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of complement activation lectin pathway GO:0001869 2 1.000
regulation of complement activation lectin pathway GO:0001868 2 0.999
sterol transport GO:0015918 39 0.999
phospholipid efflux GO:0033700 11 0.999
regulation of triglyceride metabolic process GO:0090207 11 0.999
negative regulation of protein activation cascade GO:2000258 7 0.997
protein lipid complex remodeling GO:0034368 16 0.994
phospholipid catabolic process GO:0009395 12 0.989
glycerolipid metabolic process GO:0046486 107 0.988
macromolecular complex remodeling GO:0034367 16 0.987
organophosphate ester transport GO:0015748 32 0.987
regulation of macrophage chemotaxis GO:0010758 4 0.986
lipid metabolic process GO:0006629 381 0.983
neutral lipid metabolic process GO:0006638 27 0.981
regulation of lipid catabolic process GO:0050994 23 0.972
lipid localization GO:0010876 106 0.968
negative regulation of sterol transport GO:0032372 8 0.966
fatty acid metabolic process GO:0006631 115 0.962
regulation of plasma lipoprotein particle levels GO:0097006 32 0.959
glycerolipid catabolic process GO:0046503 18 0.952
neutral lipid catabolic process GO:0046461 12 0.948
lipid transport GO:0006869 90 0.946
regulation of triglyceride catabolic process GO:0010896 6 0.941
regulation of sterol transport GO:0032371 21 0.940
very low density lipoprotein particle clearance GO:0034447 6 0.938
protein lipid complex subunit organization GO:0071825 24 0.924
glycerolipid biosynthetic process GO:0045017 51 0.915
Human
regulation of lipase activity GO:0060191 37 0.907
cholesterol transport GO:0030301 39 0.904
phosphatidylcholine metabolic process GO:0046470 19 0.903
Human
organic hydroxy compound metabolic process GO:1901615 147 0.903
regulation of lipid metabolic process GO:0019216 96 0.902
cellular ketone metabolic process GO:0042180 80 0.891
response to cytokine GO:0034097 232 0.890
Human
regulation of triglyceride biosynthetic process GO:0010866 5 0.881
acylglycerol biosynthetic process GO:0046463 11 0.881
organic anion transport GO:0015711 103 0.875
regulation of cellular ketone metabolic process GO:0010565 50 0.869
triglyceride rich lipoprotein particle clearance GO:0071830 4 0.867
phospholipid transport GO:0015914 23 0.859
regulation of cytokine production GO:0001817 232 0.858
Human
negative regulation of hydrogen peroxide metabolic process GO:0010727 3 0.854
negative regulation of lipid metabolic process GO:0045833 38 0.853
plasma lipoprotein particle organization GO:0071827 22 0.850
cellular amine metabolic process GO:0044106 41 0.833
Human
positive regulation of cytokine production GO:0001819 167 0.832
cellular lipid metabolic process GO:0044255 303 0.827
positive regulation of lipid storage GO:0010884 10 0.812
carboxylic acid biosynthetic process GO:0046394 97 0.807
hydrogen peroxide metabolic process GO:0042743 20 0.801
organic hydroxy compound transport GO:0015850 63 0.800
negative regulation of cholesterol transport GO:0032375 8 0.792
regulation of immune response GO:0050776 201 0.792
Human
defense response GO:0006952 315 0.773
Human Mouse
alcohol metabolic process GO:0006066 114 0.770
neutral lipid biosynthetic process GO:0046460 11 0.765
sterol homeostasis GO:0055092 28 0.762
acylglycerol metabolic process GO:0006639 27 0.758
steroid metabolic process GO:0008202 94 0.746
negative regulation of catalytic activity GO:0043086 335 0.741
regulation of cytokine secretion GO:0050707 57 0.741
Human
innate immune response GO:0045087 178 0.727
triglyceride biosynthetic process GO:0019432 10 0.724
regulation of locomotion GO:0040012 329 0.708
positive regulation of cellular component organization GO:0051130 376 0.706
response to oxygen containing compound GO:1901700 369 0.704
cellular biogenic amine metabolic process GO:0006576 34 0.694
Human
small molecule catabolic process GO:0044282 92 0.674
Mouse
monocarboxylic acid biosynthetic process GO:0072330 67 0.672
regulation of wound healing GO:0061041 56 0.660
vesicle mediated transport GO:0016192 371 0.657
amine metabolic process GO:0009308 44 0.636
Human
chemokine production GO:0032602 32 0.624
regulation of leukocyte migration GO:0002685 63 0.624
regulation of protein secretion GO:0050708 86 0.622
Human
negative regulation of cell motility GO:2000146 104 0.611
cellular lipid catabolic process GO:0044242 65 0.600
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.573
lipopolysaccharide transport GO:0015920 2 0.573
negative regulation of multicellular organismal process GO:0051241 317 0.563
cytokine secretion GO:0050663 64 0.546
Human
small molecule biosynthetic process GO:0044283 157 0.543
cellular response to oxygen containing compound GO:1901701 276 0.537
g protein coupled receptor signaling pathway GO:0007186 207 0.530
regulation of cell migration GO:0030334 289 0.523
positive regulation of transport GO:0051050 336 0.496
organophosphate catabolic process GO:0046434 430 0.493
regulation of protein localization GO:0032880 296 0.492
Human
positive regulation of immune system process GO:0002684 283 0.487
negative regulation of immune system process GO:0002683 136 0.477
Human
phospholipid metabolic process GO:0006644 99 0.477
Human
regulation of secretion by cell GO:1903530 177 0.473
Human
oxidation reduction process GO:0055114 396 0.471
negative regulation of humoral immune response GO:0002921 7 0.468
anion transport GO:0006820 161 0.445
lipid catabolic process GO:0016042 84 0.439
Mouse
regulation of oxidoreductase activity GO:0051341 43 0.438
negative regulation of wound healing GO:0061045 25 0.435
fatty acid biosynthetic process GO:0006633 46 0.434
positive regulation of cellular amine metabolic process GO:0033240 7 0.434
positive regulation of triglyceride metabolic process GO:0090208 9 0.426
negative regulation of complement activation GO:0045916 7 0.423
negative regulation of hydrolase activity GO:0051346 182 0.421
glycerophospholipid catabolic process GO:0046475 6 0.420
regulation of establishment of protein localization GO:0070201 242 0.418
Human
positive regulation of lipoprotein lipase activity GO:0051006 7 0.415
cardiovascular system development GO:0072358 262 0.412
Mouse
cholesterol efflux GO:0033344 28 0.410
organic acid biosynthetic process GO:0016053 97 0.410
negative regulation of leukocyte migration GO:0002686 14 0.407
positive regulation of phosphorylation GO:0042327 394 0.393
triglyceride metabolic process GO:0006641 23 0.391
negative regulation of lipoprotein particle clearance GO:0010985 5 0.389
inflammatory response GO:0006954 79 0.389
Human Mouse
positive regulation of protein transport GO:0051222 135 0.388
negative regulation of protein processing GO:0010955 142 0.386
ethanolamine containing compound metabolic process GO:0042439 26 0.385
Human
regulation of vesicle mediated transport GO:0060627 130 0.385
chemical homeostasis GO:0048878 306 0.385
positive regulation of protein phosphorylation GO:0001934 313 0.379
regulation of cellular component movement GO:0051270 334 0.375
negative regulation of immune effector process GO:0002698 38 0.367
Human
cell chemotaxis GO:0060326 112 0.363
mapk cascade GO:0000165 288 0.358
glycerophospholipid metabolic process GO:0006650 84 0.354
Human
regulation of defense response GO:0031347 154 0.346
Human Mouse
circulatory system development GO:0072359 262 0.342
Mouse
regulation of lipid transport GO:0032368 44 0.339
stem cell differentiation GO:0048863 93 0.337
cellular response to organic cyclic compound GO:0071407 127 0.319
protein activation cascade GO:0072376 22 0.319
negative regulation of developmental process GO:0051093 247 0.317
postsynaptic membrane organization GO:0001941 2 0.307
triglyceride catabolic process GO:0019433 10 0.304
sterol metabolic process GO:0016125 28 0.297
regulation of response to external stimulus GO:0032101 222 0.296
regulation of response to wounding GO:1903034 101 0.293
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.291
positive regulation of immune response GO:0050778 159 0.287
regulation of complement activation GO:0030449 8 0.280
positive regulation of lipid metabolic process GO:0045834 50 0.277
regulation of secretion GO:0051046 194 0.272
Human
negative regulation of macrophage chemotaxis GO:0010760 1 0.269
negative regulation of response to external stimulus GO:0032102 83 0.269
response to abiotic stimulus GO:0009628 336 0.269
regulation of lipoprotein lipase activity GO:0051004 12 0.266
negative regulation of protein maturation GO:1903318 142 0.262
response to metal ion GO:0010038 84 0.259
positive regulation of transferase activity GO:0051347 227 0.256
secretion GO:0046903 254 0.252
Human
positive regulation of programmed cell death GO:0043068 249 0.252
cell activation GO:0001775 213 0.242
cholesterol homeostasis GO:0042632 28 0.241
protein secretion GO:0009306 98 0.240
Human
regulation of immune effector process GO:0002697 91 0.239
Human
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.237
negative regulation of lipid catabolic process GO:0050995 9 0.236
regulation of endocytosis GO:0030100 72 0.236
positive regulation of cytokine secretion GO:0050715 42 0.232
positive regulation of protein kinase activity GO:0045860 190 0.231
taxis GO:0042330 157 0.230
Human
regulation of chemotaxis GO:0050920 74 0.230
negative regulation of peptidase activity GO:0010466 91 0.228
vitamin e metabolic process GO:0042360 1 0.225
phosphatidylcholine catabolic process GO:0034638 3 0.224
cytokine mediated signaling pathway GO:0019221 109 0.222
Human
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.222
secretion by cell GO:0032940 226 0.221
Human
complement activation lectin pathway GO:0001867 7 0.211
immune response GO:0006955 307 0.209
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.208
regulation of cellular response to oxidative stress GO:1900407 26 0.208
negative regulation of catabolic process GO:0009895 104 0.203
regulation of hydrogen peroxide metabolic process GO:0010310 6 0.203
blood vessel development GO:0001568 172 0.203
Mouse
response to lipid GO:0033993 206 0.201
regulation of protein maturation GO:1903317 150 0.200
positive regulation of cell death GO:0010942 263 0.199
negative regulation of endocytosis GO:0045806 19 0.194
regulation of transferase activity GO:0051338 355 0.193
regulation of fatty acid metabolic process GO:0019217 24 0.191
regulation of leukocyte chemotaxis GO:0002688 46 0.190
negative regulation of response to wounding GO:1903035 47 0.190
response to reactive oxygen species GO:0000302 61 0.189
positive regulation of mapk cascade GO:0043410 190 0.188
negative regulation of transport GO:0051051 176 0.188
negative regulation of cellular protein metabolic process GO:0032269 353 0.187
negative regulation of cell death GO:0060548 345 0.187
cellular response to oxidative stress GO:0034599 85 0.187
response to wounding GO:0009611 168 0.185
regulation of innate immune response GO:0045088 97 0.185
plasma lipoprotein particle clearance GO:0034381 16 0.183
regulation of lipid biosynthetic process GO:0046890 47 0.176
negative regulation of proteolysis GO:0045861 132 0.173
response to inorganic substance GO:0010035 127 0.173
negative regulation of cell migration GO:0030336 102 0.170
protein processing GO:0016485 226 0.170
negative regulation of defense response GO:0031348 47 0.167
Human Mouse
lipid biosynthetic process GO:0008610 177 0.165
leukocyte chemotaxis GO:0030595 76 0.162
regulation of protein kinase activity GO:0045859 289 0.161
cholesterol import GO:0070508 4 0.161
Human
positive regulation vascular endothelial growth factor production GO:0010575 12 0.160
response to organic cyclic compound GO:0014070 204 0.159
chemotaxis GO:0006935 157 0.158
Human
regulation of cell differentiation GO:0045595 393 0.158
sterol esterification GO:0034434 10 0.156
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.156
negative regulation of cell proliferation GO:0008285 228 0.155
negative regulation of cellular amine metabolic process GO:0033239 3 0.155
endothelial cell migration GO:0043542 86 0.154
negative regulation of lipid transport GO:0032369 18 0.153
regulation of receptor mediated endocytosis GO:0048259 32 0.151
rho protein signal transduction GO:0007266 26 0.151
lipid homeostasis GO:0055088 39 0.151
positive regulation of secretion by cell GO:1903532 108 0.150
circulatory system process GO:0003013 113 0.150
Mouse
regulation of chemokine production GO:0032642 31 0.150
negative regulation of cytokine production GO:0001818 82 0.147
Human
cellular response to hydrogen peroxide GO:0070301 37 0.146
high density lipoprotein particle remodeling GO:0034375 8 0.144
response to lipopolysaccharide GO:0032496 70 0.140
regulation of cytoskeleton organization GO:0051493 177 0.140
Human
negative regulation of cellular component movement GO:0051271 106 0.137
regulation of response to oxidative stress GO:1902882 26 0.136
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.132
cellular amino acid metabolic process GO:0006520 116 0.132
negative regulation of cellular component organization GO:0051129 235 0.129
very low density lipoprotein particle remodeling GO:0034372 10 0.129
smooth muscle cell proliferation GO:0048659 28 0.128
cellular component morphogenesis GO:0032989 314 0.128
Human
positive regulation of g protein coupled receptor protein signaling pathway GO:0045745 9 0.124
regulation of cholesterol transport GO:0032374 21 0.124
receptor mediated endocytosis GO:0006898 84 0.124
regulation of cellular amine metabolic process GO:0033238 11 0.123
regulation of g protein coupled receptor protein signaling pathway GO:0008277 35 0.122
negative regulation of platelet derived growth factor receptor signaling pathway GO:0010642 4 0.119
regulation of fatty acid biosynthetic process GO:0042304 9 0.118
maintenance of location GO:0051235 112 0.118
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.117
activation of immune response GO:0002253 114 0.117
regulation of protein serine threonine kinase activity GO:0071900 179 0.116
positive regulation of cell differentiation GO:0045597 211 0.115
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.113
regulation of kinase activity GO:0043549 314 0.113
hexose transport GO:0008645 30 0.111
regulation of cellular component biogenesis GO:0044087 281 0.110
alcohol catabolic process GO:0046164 20 0.110
Mouse
positive regulation of cell proliferation GO:0008284 301 0.110
system process GO:0003008 349 0.110
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.109
monosaccharide transport GO:0015749 32 0.109
gland development GO:0048732 48 0.109
regulation of mapk cascade GO:0043408 262 0.108
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.108
biological adhesion GO:0022610 331 0.108
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.105
lipid modification GO:0030258 84 0.104
positive regulation of nucleotide metabolic process GO:0045981 230 0.104
response to nitrogen compound GO:1901698 184 0.100
cdc42 protein signal transduction GO:0032488 4 0.100
negative regulation of protein metabolic process GO:0051248 391 0.099
actin cytoskeleton organization GO:0030036 207 0.098
Human
regulation of apoptotic cell clearance GO:2000425 5 0.097
response to hydrogen peroxide GO:0042542 40 0.093
humoral immune response GO:0006959 49 0.092
response to biotic stimulus GO:0009607 276 0.091
reverse cholesterol transport GO:0043691 8 0.088
leukocyte migration GO:0050900 107 0.087
regulation of cellular response to stress GO:0080135 244 0.087
endocytosis GO:0006897 159 0.087
protein oligomerization GO:0051259 173 0.087
regulation of proteolysis GO:0030162 293 0.086
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.085
response to oxidative stress GO:0006979 121 0.085
Mouse
regulation of protein activation cascade GO:2000257 8 0.084
regulation of smooth muscle cell migration GO:0014910 15 0.083
cellular response to cytokine stimulus GO:0071345 181 0.082
Human
regulation of cell activation GO:0050865 125 0.082
positive regulation of glucose transport GO:0010828 17 0.081
aging GO:0007568 66 0.081
positive regulation of phagocytosis GO:0050766 15 0.080
positive regulation of defense response GO:0031349 87 0.080
positive regulation of cytoskeleton organization GO:0051495 83 0.080
Human
organic hydroxy compound catabolic process GO:1901616 22 0.079
Mouse
membrane organization GO:0061024 292 0.079
positive regulation of developmental process GO:0051094 314 0.077
cell development GO:0048468 328 0.077
regulation of cell motility GO:2000145 299 0.076
acute inflammatory response GO:0002526 21 0.075
positive regulation of lipid biosynthetic process GO:0046889 22 0.075
cytokine production GO:0001816 247 0.074
Human
negative regulation of endopeptidase activity GO:0010951 84 0.074
positive regulation of cellular component biogenesis GO:0044089 158 0.072
positive regulation of fatty acid biosynthetic process GO:0045723 5 0.072
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.072
regulation of cholesterol esterification GO:0010872 7 0.071
immune effector process GO:0002252 159 0.070
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.070
positive regulation of chemokine production GO:0032722 22 0.070
response to hormone GO:0009725 175 0.070
protein catabolic process GO:0030163 325 0.069
reactive oxygen species metabolic process GO:0072593 75 0.069
regulation of peptidase activity GO:0052547 180 0.069
negative regulation of locomotion GO:0040013 118 0.067
negative regulation of cellular response to oxidative stress GO:1900408 18 0.066
positive regulation of catabolic process GO:0009896 310 0.066
negative regulation of lipid biosynthetic process GO:0051055 22 0.066
positive regulation of kinase activity GO:0033674 204 0.066
organonitrogen compound biosynthetic process GO:1901566 200 0.066
epithelial cell migration GO:0010631 119 0.065
positive regulation of protein secretion GO:0050714 60 0.065
cellular response to reactive oxygen species GO:0034614 50 0.065
regulation of endopeptidase activity GO:0052548 170 0.064
myeloid leukocyte migration GO:0097529 62 0.064
hydrogen peroxide catabolic process GO:0042744 13 0.064
response to bacterium GO:0009617 144 0.063
regulation of acute inflammatory response GO:0002673 13 0.062
negative regulation of immune response GO:0050777 40 0.062
Human
response to transforming growth factor beta GO:0071559 94 0.062
positive regulation of lipase activity GO:0060193 28 0.061
negative regulation of macrophage activation GO:0043031 1 0.060
negative regulation of binding GO:0051100 57 0.060
defense response to bacterium GO:0042742 63 0.060
regulation of binding GO:0051098 111 0.059
apoptotic signaling pathway GO:0097190 268 0.059
regulation of protein transport GO:0051223 213 0.058
Human
cell adhesion molecule production GO:0060352 3 0.058
Human
immune response regulating signaling pathway GO:0002764 97 0.058
small gtpase mediated signal transduction GO:0007264 78 0.057
regulation of response to reactive oxygen species GO:1901031 12 0.057
cell projection organization GO:0030030 252 0.056
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.056
negative regulation of tumor necrosis factor production GO:0032720 20 0.056
positive regulation of renal albumin absorption GO:2000534 1 0.055
hematopoietic or lymphoid organ development GO:0048534 186 0.055
cellular response to tumor necrosis factor GO:0071356 63 0.054
Human
negative regulation of response to oxidative stress GO:1902883 18 0.054
cholesterol metabolic process GO:0008203 28 0.053
positive regulation of hydrolase activity GO:0051345 331 0.053
Human
cellular cation homeostasis GO:0030003 163 0.053
Mouse
positive regulation of chemokine secretion GO:0090197 6 0.052
glucose transport GO:0015758 30 0.052
positive regulation of apoptotic cell clearance GO:2000427 5 0.052
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.051
positive regulation of secretion GO:0051047 116 0.051
negative regulation of receptor mediated endocytosis GO:0048261 6 0.050
cellular amide metabolic process GO:0043603 69 0.050
response to growth factor GO:0070848 205 0.050
regulation of glucose transport GO:0010827 23 0.050
response to alcohol GO:0097305 64 0.050
positive regulation of nucleotide catabolic process GO:0030813 185 0.049
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.049
regulation of heterotypic cell cell adhesion GO:0034114 14 0.049
Human
positive regulation of cellular catabolic process GO:0031331 284 0.047
protein maturation GO:0051604 233 0.047
defense response to gram positive bacterium GO:0050830 29 0.046
behavior GO:0007610 112 0.046
negative regulation of hemostasis GO:1900047 22 0.046
regulation of protein processing GO:0070613 150 0.046
negative regulation of phosphorylation GO:0042326 174 0.046
positive regulation of triglyceride lipase activity GO:0061365 7 0.045
negative regulation of cell adhesion GO:0007162 64 0.045
Human
organophosphate biosynthetic process GO:0090407 163 0.045
regulation of coagulation GO:0050818 44 0.044
multicellular organismal macromolecule metabolic process GO:0044259 29 0.044
positive regulation of corticosteroid hormone secretion GO:2000848 5 0.043
regulation of nucleotide biosynthetic process GO:0030808 50 0.042
regulation of interleukin 8 production GO:0032677 49 0.042
immune system development GO:0002520 195 0.042
positive regulation of cgmp biosynthetic process GO:0030828 3 0.042
response to organonitrogen compound GO:0010243 156 0.042
positive regulation of cell migration GO:0030335 172 0.042
muscle cell proliferation GO:0033002 35 0.042
positive regulation of apoptotic process GO:0043065 246 0.041
response to molecule of bacterial origin GO:0002237 82 0.041
multicellular organismal aging GO:0010259 3 0.041
positive regulation of protein catabolic process GO:0045732 75 0.041
post embryonic development GO:0009791 2 0.040
regulation of phospholipid catabolic process GO:0060696 3 0.040
transmembrane transport GO:0055085 399 0.040
Human
response to acid chemical GO:0001101 66 0.040
single organism cell adhesion GO:0098602 179 0.040
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.040
regulation of actin filament based process GO:0032970 141 0.039
Human
epithelial cell proliferation GO:0050673 128 0.039
single organism carbohydrate metabolic process GO:0044723 193 0.039
regulation of erk1 and erk2 cascade GO:0070372 99 0.038
lipid storage GO:0019915 28 0.038
protein import GO:0017038 130 0.038
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.038
regulation of cellular response to growth factor stimulus GO:0090287 76 0.038
positive regulation of cholesterol efflux GO:0010875 8 0.038
signal transduction by phosphorylation GO:0023014 297 0.037
purine nucleoside triphosphate catabolic process GO:0009146 392 0.037
carbohydrate derivative transport GO:1901264 20 0.037
regulation of map kinase activity GO:0043405 108 0.035
regulation of hemostasis GO:1900046 42 0.035
nucleotide catabolic process GO:0009166 408 0.035
positive regulation of cell motility GO:2000147 177 0.035
nervous system development GO:0007399 293 0.035
cellular response to endogenous stimulus GO:0071495 336 0.035
cyclic nucleotide metabolic process GO:0009187 82 0.034
tube morphogenesis GO:0035239 95 0.034
Human
vascular endothelial growth factor production GO:0010573 15 0.034
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 38 0.034
positive regulation of organelle organization GO:0010638 195 0.033
Human
detection of stimulus GO:0051606 85 0.033
second messenger mediated signaling GO:0019932 78 0.033
regulation of leukocyte activation GO:0002694 115 0.033
detection of chemical stimulus GO:0009593 55 0.033
negative regulation of protein phosphorylation GO:0001933 140 0.033
cellular response to metal ion GO:0071248 43 0.032
divalent metal ion transport GO:0070838 152 0.032
stem cell development GO:0048864 69 0.032
monocarboxylic acid metabolic process GO:0032787 185 0.032
regulation of cytokine mediated signaling pathway GO:0001959 41 0.032
Human
plasma lipoprotein particle remodeling GO:0034369 16 0.032
atrioventricular valve development GO:0003171 3 0.032
negative regulation of platelet aggregation GO:0090331 3 0.032
cellular response to molecule of bacterial origin GO:0071219 62 0.031
modification of morphology or physiology of other organism GO:0035821 43 0.031
negative regulation of programmed cell death GO:0043069 321 0.031
nitrogen cycle metabolic process GO:0071941 3 0.031
lipoprotein modification GO:0042160 4 0.030
regulation of carbohydrate metabolic process GO:0006109 54 0.030
ras protein signal transduction GO:0007265 73 0.030
apoptotic cell clearance GO:0043277 12 0.030
negative regulation of innate immune response GO:0045824 18 0.030
response to activity GO:0014823 0 0.029
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.029
cellular response to lipid GO:0071396 127 0.029
response to external biotic stimulus GO:0043207 261 0.029
negative regulation of alpha beta t cell activation GO:0046636 3 0.029
regulation of lipid storage GO:0010883 21 0.029
peptidyl tyrosine modification GO:0018212 170 0.029
regulation of protein complex assembly GO:0043254 147 0.028
response to increased oxygen levels GO:0036296 4 0.028
response to other organism GO:0051707 261 0.027
mitotic cell cycle process GO:1903047 286 0.027
cholesterol esterification GO:0034435 10 0.027
smooth muscle cell migration GO:0014909 18 0.027
regulation of protein binding GO:0043393 66 0.027
digestive tract development GO:0048565 75 0.027
Human
metal ion homeostasis GO:0055065 169 0.026
Mouse
unsaturated fatty acid metabolic process GO:0033559 37 0.026
regulation of stress activated mapk cascade GO:0032872 84 0.026
nucleoside triphosphate catabolic process GO:0009143 394 0.026
response to axon injury GO:0048678 1 0.026
hexose metabolic process GO:0019318 55 0.026
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.026
regulation of mononuclear cell proliferation GO:0032944 65 0.026
purine ribonucleotide catabolic process GO:0009154 404 0.025
mesenchymal cell differentiation GO:0048762 52 0.025
immune response activating signal transduction GO:0002757 90 0.025
regulation of blood pressure GO:0008217 30 0.025
lipoprotein metabolic process GO:0042157 42 0.025
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.025
ribonucleoside triphosphate metabolic process GO:0009199 412 0.025
regulation of intracellular protein transport GO:0033157 123 0.025
positive regulation of apoptotic signaling pathway GO:2001235 70 0.025
interleukin 8 production GO:0032637 51 0.025
regulation of synaptic plasticity GO:0048167 3 0.025
neuron differentiation GO:0030182 138 0.025
t cell activation GO:0042110 99 0.025
regulation of homeostatic process GO:0032844 121 0.024
oogenesis GO:0048477 2 0.024
embryo development GO:0009790 123 0.024
Human
positive regulation of cholesterol esterification GO:0010873 6 0.024
regulation of blood coagulation GO:0030193 42 0.024
protein localization to membrane GO:0072657 160 0.024
positive regulation of fatty acid metabolic process GO:0045923 11 0.024
lipoprotein oxidation GO:0042161 4 0.024
cyclic purine nucleotide metabolic process GO:0052652 60 0.024
anion homeostasis GO:0055081 18 0.024
regulation of epithelial cell proliferation GO:0050678 113 0.023
response to transition metal nanoparticle GO:1990267 29 0.023
negative regulation of apoptotic process GO:0043066 316 0.023
regulation of cell projection organization GO:0031344 107 0.023

APOE disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.899
neurodegenerative disease DOID:1289 102 0.899
nervous system disease DOID:863 431 0.899
disease of metabolism DOID:0014667 295 0.854
inherited metabolic disorder DOID:655 242 0.854
disease of mental health DOID:150 70 0.843
tauopathy DOID:680 16 0.826
cognitive disorder DOID:1561 29 0.615
dementia DOID:1307 19 0.593
alzheimer s disease DOID:10652 16 0.593
sensory system disease DOID:0050155 203 0.032
lipid metabolism disorder DOID:3146 26 0.031
cardiovascular system disease DOID:1287 106 0.031
musculoskeletal system disease DOID:17 223 0.026
hypertension DOID:10763 13 0.025
artery disease DOID:0050828 23 0.025
vascular disease DOID:178 25 0.025
essential hypertension DOID:10825 8 0.025