IMP

Process View

Homo sapiens

1 genes annotated in human

complement component c5a signaling pathway

A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "complement component c5a signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "complement component c5a signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CD163	CD163 molecule	0.710
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.670
VSIG4	V-set and immunoglobulin domain containing 4	0.618
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.617
CCR1	chemokine (C-C motif) receptor 1	0.332
MARCO	macrophage receptor with collagenous structure	0.258
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.252
TREM1	triggering receptor expressed on myeloid cells 1	0.203
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.184
AQP9	aquaporin 9	0.179
C1QA	complement component 1, q subcomponent, A chain	0.159
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.157
FPR1	formyl peptide receptor 1	0.130	Human
SLAMF8	SLAM family member 8	0.106
C5AR1	complement component 5a receptor 1	0.098
CLEC5A	C-type lectin domain family 5, member A	0.091
MSR1	macrophage scavenger receptor 1	0.086
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.085
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.081
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.071
SIGLEC7	sialic acid binding Ig-like lectin 7	0.071
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.070
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.070
CD14	CD14 molecule	0.070
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.063
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.061
CD93	CD93 molecule	0.057
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.046
CYBB	cytochrome b-245, beta polypeptide	0.041
CD86	CD86 molecule	0.041
MPEG1	macrophage expressed 1	0.040
CD68	CD68 molecule	0.039
FPR3	formyl peptide receptor 3	0.038	Human
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.037
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.034
CLEC4E	C-type lectin domain family 4, member E	0.034
ADORA3	adenosine A3 receptor	0.033
IGSF6	immunoglobulin superfamily, member 6	0.033
CLEC4A	C-type lectin domain family 4, member A	0.029
AOAH	acyloxyacyl hydrolase (neutrophil)	0.029
LY86	lymphocyte antigen 86	0.026
HK3	hexokinase 3 (white cell)	0.025
IL10	interleukin 10	0.025
CSF1R	colony stimulating factor 1 receptor	0.024
C3AR1	complement component 3a receptor 1	0.024	Human
C1QC	complement component 1, q subcomponent, C chain	0.024
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.023
S100A12	S100 calcium binding protein A12	0.023
CLEC7A	C-type lectin domain family 7, member A	0.023
CMKLR1	chemokine-like receptor 1	0.022	Human
FPR2	formyl peptide receptor 2	0.022	Human
ALOX5	arachidonate 5-lipoxygenase	0.021
CD300A	CD300a molecule	0.021
SIGLEC9	sialic acid binding Ig-like lectin 9	0.021
IL1B	interleukin 1, beta	0.020
TLR2	toll-like receptor 2	0.020
CCL8	chemokine (C-C motif) ligand 8	0.020
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.019
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
PTAFR	platelet-activating factor receptor	0.018
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.018
HCK	hemopoietic cell kinase	0.018
C2	complement component 2	0.016
FYB	FYN binding protein	0.016
CXCL10	chemokine (C-X-C motif) ligand 10	0.016
CCR5	chemokine (C-C motif) receptor 5	0.016
EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	0.015
IL1R2	interleukin 1 receptor, type II	0.014
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.014
CCL4	chemokine (C-C motif) ligand 4	0.014
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.014
C1QB	complement component 1, q subcomponent, B chain	0.013
CXCL9	chemokine (C-X-C motif) ligand 9	0.013
NLRP3	NLR family, pyrin domain containing 3	0.013
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.013
ADAP2	ArfGAP with dual PH domains 2	0.013
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.013
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.012
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.012
TLR8	toll-like receptor 8	0.012
IL1RN	interleukin 1 receptor antagonist	0.012
GPR84	G protein-coupled receptor 84	0.012
FFAR2	free fatty acid receptor 2	0.012
KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	0.012
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.011
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.011
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.011
STAB1	stabilin 1	0.011
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.011
ADPRH	ADP-ribosylarginine hydrolase	0.011
CCL7	chemokine (C-C motif) ligand 7	0.011
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.010
SLC15A3	solute carrier family 15, member 3	0.010
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.010
NOD2	nucleotide-binding oligomerization domain containing 2	0.010
F13A1	coagulation factor XIII, A1 polypeptide	0.010
IL18RAP	interleukin 18 receptor accessory protein	0.010
FCAR	Fc fragment of IgA, receptor for	0.010