IMP
Process View
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process.
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nucleotide binding domain leucine rich repeat containing receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 1.000 | Human | |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.996 | ||
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.992 | Human | |
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.973 | Human | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.924 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.835 | ||
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.564 | ||
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.550 | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.464 | Mouse | |
| TRAF1 | TNF receptor-associated factor 1 | 0.218 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.179 | ||
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.153 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.119 | Human | |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.117 | ||
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.099 | Human | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.081 | ||
| BCL3 | B-cell CLL/lymphoma 3 | 0.074 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.043 | ||
| BIRC2 | baculoviral IAP repeat containing 2 | 0.042 | ||
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.023 | ||
| TNIP1 | TNFAIP3 interacting protein 1 | 0.020 | ||
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.019 | Human | |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.019 | ||
| TRAF2 | TNF receptor-associated factor 2 | 0.017 | ||
| TRAF6 | TNF receptor-associated factor 6 | 0.012 |