IMP

Process View

Homo sapiens

2 genes annotated in human

menaquinone catabolic process

The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "menaquinone catabolic process"

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Name	Description	Probability	Func Analog Organism
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.996
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.855
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.820	Human
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.777	Human
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.759
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.512
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.420
C8A	complement component 8, alpha polypeptide	0.343
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.285
KNG1	kininogen 1	0.233
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.149
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.147
PLG	plasminogen	0.120
DAO	D-amino-acid oxidase	0.102
RDH16	retinol dehydrogenase 16 (all-trans)	0.097
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.096
ADH6	alcohol dehydrogenase 6 (class V)	0.094
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.087
MAT1A	methionine adenosyltransferase I, alpha	0.080
C4BPA	complement component 4 binding protein, alpha	0.079
G6PC	glucose-6-phosphatase, catalytic subunit	0.077
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.076
FABP1	fatty acid binding protein 1, liver	0.064
MASP2	mannan-binding lectin serine peptidase 2	0.063
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	0.061
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.059	Human
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.059
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.058
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.058
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.057
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.055
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.054
HPD	4-hydroxyphenylpyruvate dioxygenase	0.052
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.045
HRG	histidine-rich glycoprotein	0.045
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.041
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.039
DIO1	deiodinase, iodothyronine, type I	0.038
ARG1	arginase, liver	0.036
OTC	ornithine carbamoyltransferase	0.036
CYP4F8	cytochrome P450, family 4, subfamily F, polypeptide 8	0.036	Human
C8B	complement component 8, beta polypeptide	0.035
HNF4A	hepatocyte nuclear factor 4, alpha	0.035
GLYAT	glycine-N-acyltransferase	0.034
F9	coagulation factor IX	0.034
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.033
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.031
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.030
BHMT	betaine--homocysteine S-methyltransferase	0.030
FETUB	fetuin B	0.029
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.028
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.028
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.028
PAH	phenylalanine hydroxylase	0.028
SCGB2A1	secretoglobin, family 2A, member 1	0.027
PIP	prolactin-induced protein	0.027
HAL	histidine ammonia-lyase	0.026
GSTA3	glutathione S-transferase alpha 3	0.025
AADAC	arylacetamide deacetylase (esterase)	0.024
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.023
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.023
HGD	homogentisate 1,2-dioxygenase	0.023
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	0.022	Human
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.022
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.022
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.022
F13B	coagulation factor XIII, B polypeptide	0.021
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.021
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.021
TMPRSS4	transmembrane protease, serine 4	0.021
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.021
APOF	apolipoprotein F	0.021
KRT13	keratin 13	0.020
PKLR	pyruvate kinase, liver and RBC	0.020
EPHX2	epoxide hydrolase 2, cytoplasmic	0.020
DEFB1	defensin, beta 1	0.019
ORM1	orosomucoid 1	0.019
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.019
C9	complement component 9	0.019
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.018
APOC3	apolipoprotein C-III	0.018
NAT8	N-acetyltransferase 8 (GCN5-related, putative)	0.018
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.018
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.018
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.018
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.017
C6	complement component 6	0.017
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.017
LPA	lipoprotein, Lp(a)	0.017
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.017
ADRA1A	adrenergic, alpha-1A-, receptor	0.016
DPYS	dihydropyrimidinase	0.016
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.015
FABP2	fatty acid binding protein 2, intestinal	0.015
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.015
PRLR	prolactin receptor	0.015
C8G	complement component 8, gamma polypeptide	0.015
CFHR4	complement factor H-related 4	0.014
IL22RA1	interleukin 22 receptor, alpha 1	0.014
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.014
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.014
HPX	hemopexin	0.014
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.014
SLC38A3	solute carrier family 38, member 3	0.014
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.013
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.013
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.013
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	0.012
FMO4	flavin containing monooxygenase 4	0.012
TREH	trehalase (brush-border membrane glycoprotein)	0.012
C4BPB	complement component 4 binding protein, beta	0.012
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.012
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.012
AQP7	aquaporin 7	0.012
AGXT	alanine-glyoxylate aminotransferase	0.012
KRT4	keratin 4	0.012
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.012
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.011
CRP	C-reactive protein, pentraxin-related	0.011
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.011
PRODH	proline dehydrogenase (oxidase) 1	0.011
CYP4A22	cytochrome P450, family 4, subfamily A, polypeptide 22	0.011	Human
CNGA1	cyclic nucleotide gated channel alpha 1	0.011
SPP2	secreted phosphoprotein 2, 24kDa	0.011
PIPOX	pipecolic acid oxidase	0.011
CA5A	carbonic anhydrase VA, mitochondrial	0.011
CPB2	carboxypeptidase B2 (plasma)	0.011
VTCN1	V-set domain containing T cell activation inhibitor 1	0.011
S100A14	S100 calcium binding protein A14	0.011
CRISP3	cysteine-rich secretory protein 3	0.011
IL1RL2	interleukin 1 receptor-like 2	0.010
KHK	ketohexokinase (fructokinase)	0.010
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.010
GSTT1	glutathione S-transferase theta 1	0.010
CCL16	chemokine (C-C motif) ligand 16	0.010
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.010
UPB1	ureidopropionase, beta	0.010
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.010
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.010
ALDOB	aldolase B, fructose-bisphosphate	0.010
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.010