IMP
Process View
cytoplasmic pattern recognition receptor signaling pathway in response to virus
Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
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Click on a gene's description to view its network relationships with genes known to be involved in "cytoplasmic pattern recognition receptor signaling pathway in response to virus"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.585 | ||
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.441 | ||
| IFIH1 | interferon induced with helicase C domain 1 | 0.420 | Human | |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.416 | ||
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.246 | ||
| SP100 | SP100 nuclear antigen | 0.240 | ||
| IFI44L | interferon-induced protein 44-like | 0.156 | ||
| SAMD9 | sterile alpha motif domain containing 9 | 0.122 | ||
| IFI44 | interferon-induced protein 44 | 0.080 | ||
| DTX3L | deltex 3-like (Drosophila) | 0.067 | ||
| TDRD7 | tudor domain containing 7 | 0.053 | ||
| CYLD | cylindromatosis (turban tumor syndrome) | 0.048 | ||
| SP110 | SP110 nuclear body protein | 0.048 | ||
| TRIM21 | tripartite motif containing 21 | 0.046 | Human | |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 0.043 | ||
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.043 | Human | |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.042 | ||
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.033 | ||
| NMI | N-myc (and STAT) interactor | 0.031 | ||
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.024 | ||
| TRIM25 | tripartite motif containing 25 | 0.023 | ||
| HERC5 | hect domain and RLD 5 | 0.021 | ||
| OAS1 | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 0.021 | ||
| TRIM39 | tripartite motif containing 39 | 0.019 | Human | |
| TRIM5 | tripartite motif containing 5 | 0.019 | Human | |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.017 | ||
| ZNF263 | zinc finger protein 263 | 0.015 | ||
| UBE2D4 | ubiquitin-conjugating enzyme E2D 4 (putative) | 0.014 | ||
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.014 | ||
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.014 | ||
| LAP3 | leucine aminopeptidase 3 | 0.013 | ||
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.013 | ||
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | 0.011 | ||
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.010 |