IMP
Process View
leukocyte tethering or rolling
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "leukocyte tethering or rolling"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.969 | ||
| FHL2 | four and a half LIM domains 2 | 0.735 | ||
| FLNA | filamin A, alpha | 0.435 | ||
| FN1 | fibronectin 1 | 0.323 | ||
| PXN | paxillin | 0.082 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.054 | ||
| ENG | endoglin | 0.036 | ||
| ITGA6 | integrin, alpha 6 | 0.029 | Human | |
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B | 0.022 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.017 | Human | |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 0.015 | ||
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.015 | ||
| TLN1 | talin 1 | 0.015 | ||
| MYO10 | myosin X | 0.013 | ||
| VCAM1 | vascular cell adhesion molecule 1 | 0.012 | ||
| ITGAV | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 0.012 | Human | |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.012 | ||
| PLEC | plectin | 0.011 | ||
| VCL | vinculin | 0.011 | ||
| SNX20 | sorting nexin 20 | 0.010 | ||
| CD63 | CD63 molecule | 0.010 |