IMP

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Mus musculus

0 genes annotated in mouse

amyotrophic lateral sclerosis

DOID:332

A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "amyotrophic lateral sclerosis" (in gray)

Name	Description	Probability	Func Analog Organism
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.687
Ang2	angiogenin, ribonuclease A family, member 2	0.353	Human
Hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.253	Human
Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	0.174
Cfl1	cofilin 1, non-muscle	0.144
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.124
Actb	actin, beta	0.102
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.095
Pnn	pinin	0.087
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.081
Srsf11	serine/arginine-rich splicing factor 11	0.080
Upf3b	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.075
Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	0.075
Gzmg	granzyme G	0.074
Rnase4	ribonuclease, RNase A family 4	0.063
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.060
Ap2m1	adaptor protein complex AP-2, mu1	0.057
Eif4a1	eukaryotic translation initiation factor 4A1	0.055
BC051019	cDNA sequence BC051019	0.051
Taf1d	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D	0.045
Srsf10	serine/arginine-rich splicing factor 10	0.041
Rbm39	RNA binding motif protein 39	0.041
Zranb2	zinc finger, RAN-binding domain containing 2	0.031
Fam76b	family with sequence similarity 76, member B	0.031
Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.030
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.027
Cul3	cullin 3	0.027
Srsf7	serine/arginine-rich splicing factor 7	0.026
Srsf6	serine/arginine-rich splicing factor 6	0.026
Ang	angiogenin, ribonuclease, RNase A family, 5	0.025	Human
Srsf5	serine/arginine-rich splicing factor 5	0.025
Myef2	myelin basic protein expression factor 2, repressor	0.024
Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.024
Ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.023
Arpc4	actin related protein 2/3 complex, subunit 4	0.023
Klk1b5	kallikrein 1-related peptidase b5	0.022
Eed	embryonic ectoderm development	0.022
Tubb5	tubulin, beta 5	0.021
Ewsr1	Ewing sarcoma breakpoint region 1	0.021
Ivns1abp	influenza virus NS1A binding protein	0.021
Psip1	PC4 and SFRS1 interacting protein 1	0.020
Klk1b1	kallikrein 1-related peptidase b1	0.020
Otc	ornithine transcarbamylase	0.019
Hdac6	histone deacetylase 6	0.018
Hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.018
Ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.017
Pigr	polymeric immunoglobulin receptor	0.017
Coro1b	coronin, actin binding protein 1B	0.016
Tcerg1	transcription elongation regulator 1 (CA150)	0.016
Ncl	nucleolin	0.016
Ptbp2	polypyrimidine tract binding protein 2	0.016
Tyrobp	TYRO protein tyrosine kinase binding protein	0.016
Rnf138	ring finger protein 138	0.016
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.015
Luc7l3	LUC7-like 3 (S. cerevisiae)	0.015
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.015
Gjb1	gap junction protein, beta 1	0.015
Itfg1	integrin alpha FG-GAP repeat containing 1	0.015
Rbm25	RNA binding motif protein 25	0.015
Akap8	A kinase (PRKA) anchor protein 8	0.015
Mtf2	metal response element binding transcription factor 2	0.015
Capn1	calpain 1	0.014
Ufd1l	ubiquitin fusion degradation 1 like	0.014
Prpf4b	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.014
Smc5	structural maintenance of chromosomes 5	0.014
Prl7a1	prolactin family 7, subfamily a, member 1	0.014
Sec31a	Sec31 homolog A (S. cerevisiae)	0.014
Tpm3	tropomyosin 3, gamma	0.014
Hoxb13	homeobox B13	0.013
Defb9	defensin beta 9	0.013
Dhx9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.013
1700052M18Rik	RIKEN cDNA 1700052M18 gene	0.013
Arf5	ADP-ribosylation factor 5	0.013
Npm1	nucleophosmin 1	0.013
Gcfc1	GC-rich sequence DNA-binding factor 1	0.013
Lgals6	lectin, galactose binding, soluble 6	0.012
Tdp2	tyrosyl-DNA phosphodiesterase 2	0.012
Dlg4	discs, large homolog 4 (Drosophila)	0.012
Car5a	carbonic anhydrase 5a, mitochondrial	0.012
Smc4	structural maintenance of chromosomes 4	0.012
Rag2	recombination activating gene 2	0.012
Hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.011
Hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.011
Obp1a	odorant binding protein Ia	0.011
Hmgb1	high mobility group box 1	0.011
Hmgb3	high mobility group box 3	0.011
Gzmd	granzyme D	0.011
2410002F23Rik	RIKEN cDNA 2410002F23 gene	0.011
Ctdspl2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	0.011
Sf3b1	splicing factor 3b, subunit 1	0.011
Fabp1	fatty acid binding protein 1, liver	0.011
Apoc1	apolipoprotein C-I	0.010
Msh6	mutS homolog 6 (E. coli)	0.010
Vpreb1	pre-B lymphocyte gene 1	0.010