IMP
Process View
protein targeting to er
The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "protein targeting to er"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 0.673 | ||
| Creld2 | cysteine-rich with EGF-like domains 2 | 0.331 | ||
| Hspd1 | heat shock protein 1 (chaperonin) | 0.263 | ||
| Dnajb11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.256 | ||
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.239 | ||
| Iqcb1 | IQ calmodulin-binding motif containing 1 | 0.236 | ||
| Rpgrip1l | Rpgrip1-like | 0.183 | ||
| Hsph1 | heat shock 105kDa/110kDa protein 1 | 0.167 | ||
| Pdia6 | protein disulfide isomerase associated 6 | 0.163 | ||
| Manf | mesencephalic astrocyte-derived neurotrophic factor | 0.122 | ||
| Hsp90aa1 | heat shock protein 90, alpha (cytosolic), class A member 1 | 0.121 | ||
| Pdia3 | protein disulfide isomerase associated 3 | 0.095 | ||
| Hsp90ab1 | heat shock protein 90 alpha (cytosolic), class B member 1 | 0.093 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.073 | ||
| Surf4 | surfeit gene 4 | 0.064 | ||
| Nphp1 | nephronophthisis 1 (juvenile) homolog (human) | 0.063 | ||
| Hspa5 | heat shock protein 5 | 0.061 | Yeast | |
| Dnaja1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.060 | ||
| Ssr1 | signal sequence receptor, alpha | 0.057 | ||
| Invs | inversin | 0.053 | ||
| Dnajc3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.050 | ||
| P4hb | prolyl 4-hydroxylase, beta polypeptide | 0.048 | ||
| Hspa8 | heat shock protein 8 | 0.044 | Yeast | |
| Arcn1 | archain 1 | 0.037 | ||
| Sdf2l1 | stromal cell-derived factor 2-like 1 | 0.036 | ||
| Rrbp1 | ribosome binding protein 1 | 0.033 | ||
| Chordc1 | cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 | 0.032 | ||
| Xbp1 | X-box binding protein 1 | 0.032 | ||
| Clasp1 | CLIP associating protein 1 | 0.031 | ||
| Prkcsh | protein kinase C substrate 80K-H | 0.031 | ||
| Dync1h1 | dynein cytoplasmic 1 heavy chain 1 | 0.028 | ||
| Pdia4 | protein disulfide isomerase associated 4 | 0.028 | ||
| Ahi1 | Abelson helper integration site 1 | 0.026 | ||
| Spna2 | spectrin alpha 2 | 0.021 | ||
| Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.021 | ||
| Ptbp2 | polypyrimidine tract binding protein 2 | 0.020 | ||
| Calu | calumenin | 0.019 | ||
| Lman1 | lectin, mannose-binding, 1 | 0.019 | ||
| Kpna1 | karyopherin (importin) alpha 1 | 0.018 | ||
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.018 | ||
| Ntf3 | neurotrophin 3 | 0.018 | ||
| Uso1 | USO1 homolog, vesicle docking protein (yeast) | 0.018 | ||
| Spcs2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.018 | ||
| Lrrc59 | leucine rich repeat containing 59 | 0.017 | ||
| Mks1 | Meckel syndrome, type 1 | 0.017 | ||
| Erp44 | endoplasmic reticulum protein 44 | 0.017 | ||
| Gorasp2 | golgi reassembly stacking protein 2 | 0.017 | ||
| Spnb2 | spectrin beta 2 | 0.016 | ||
| Canx | calnexin | 0.016 | ||
| Hyou1 | hypoxia up-regulated 1 | 0.016 | ||
| Ssr3 | signal sequence receptor, gamma | 0.016 | ||
| Ufd1l | ubiquitin fusion degradation 1 like | 0.014 | ||
| Crk | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.014 | ||
| Slc35b1 | solute carrier family 35, member B1 | 0.013 | ||
| Rpn2 | ribophorin II | 0.013 | ||
| Tctn1 | tectonic family member 1 | 0.013 | ||
| Sel1l | sel-1 suppressor of lin-12-like (C. elegans) | 0.013 | ||
| Edem1 | ER degradation enhancer, mannosidase alpha-like 1 | 0.013 | ||
| Bdnf | brain derived neurotrophic factor | 0.012 | ||
| Calr | calreticulin | 0.012 | ||
| Nus1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.012 | ||
| P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | 0.012 | ||
| Dnajc5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.012 | ||
| Rpn1 | ribophorin I | 0.012 | ||
| Uba5 | ubiquitin-like modifier activating enzyme 5 | 0.012 | ||
| Serp1 | stress-associated endoplasmic reticulum protein 1 | 0.012 | ||
| Csnk1g2 | casein kinase 1, gamma 2 | 0.011 | ||
| Clasp2 | CLIP associating protein 2 | 0.011 | ||
| Vcp | valosin containing protein | 0.011 | ||
| Ogt | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | 0.011 | ||
| Csde1 | cold shock domain containing E1, RNA binding | 0.011 | ||
| Spcs3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.011 | ||
| Hspa1b | heat shock protein 1B | 0.011 | ||
| Actg1 | actin, gamma, cytoplasmic 1 | 0.011 | ||
| Dnaja2 | DnaJ (Hsp40) homolog, subfamily A, member 2 | 0.011 | Yeast | |
| Mtmr1 | myotubularin related protein 1 | 0.010 |