IMP

Process View

Mus musculus

3 genes annotated in mouse

antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap dependent"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap dependent" (in gray)

Name	Description	Probability	Func Analog Organism
H2-K1	histocompatibility 2, K1, K region	0.851
B2m	beta-2 microglobulin	0.821
Tapbp	TAP binding protein	0.709
H2-D1	histocompatibility 2, D region locus 1	0.616
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.598	Mouse
H2-Q7	histocompatibility 2, Q region locus 7	0.540
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.222
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.184
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.079
H2-Q6	histocompatibility 2, Q region locus 6	0.030
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.022
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.015
Cp	ceruloplasmin	0.013
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.013
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.011