IMP

Process View

Mus musculus

2 genes annotated in mouse

antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway tap dependent

The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway tap dependent"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway tap dependent" (in gray)

Name	Description	Probability	Func Analog Organism
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.760
H2-Q7	histocompatibility 2, Q region locus 7	0.742
Tapbp	TAP binding protein	0.665
B2m	beta-2 microglobulin	0.331
H2-K1	histocompatibility 2, K1, K region	0.241	Mouse
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.178
H2-D1	histocompatibility 2, D region locus 1	0.162	Mouse
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.109	Mouse
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.075
H2-Q6	histocompatibility 2, Q region locus 6	0.016
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.015
Cp	ceruloplasmin	0.015
Itm2b	integral membrane protein 2B	0.013
Stat1	signal transducer and activator of transcription 1	0.012
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.011
H2-Q8	histocompatibility 2, Q region locus 8	0.011