IMP
Process View
The network for 'dibenzo p dioxin metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
dibenzo p dioxin metabolic process
The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Hpd | 4-hydroxyphenylpyruvic acid dioxygenase | 0.682 | |
| Hsd3b6 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 | 0.591 | |
| Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 0.501 | |
| Ces3a | carboxylesterase 3A | 0.421 | |
| Hoxa10 | homeobox A10 | 0.337 | |
| C9 | complement component 9 | 0.301 | |
| Ahsg | alpha-2-HS-glycoprotein | 0.295 | |
| Cyp4a14 | cytochrome P450, family 4, subfamily a, polypeptide 14 | 0.294 | |
| Akr1c21 | aldo-keto reductase family 1, member C21 | 0.275 | |
| Cyp2a12 | cytochrome P450, family 2, subfamily a, polypeptide 12 | 0.272 | |
| Lhcgr | luteinizing hormone/choriogonadotropin receptor | 0.203 | |
| Cyp2c50 | cytochrome P450, family 2, subfamily c, polypeptide 50 | 0.186 | |
| Cps1 | carbamoyl-phosphate synthetase 1 | 0.169 | |
| Dmgdh | dimethylglycine dehydrogenase precursor | 0.167 | |
| Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 | 0.146 | |
| Nr1i3 | nuclear receptor subfamily 1, group I, member 3 | 0.143 | |
| Mbl2 | mannose-binding lectin (protein C) 2 | 0.143 | |
| Cdhr5 | cadherin-related family member 5 | 0.139 | |
| G6pc | glucose-6-phosphatase, catalytic | 0.134 | |
| Hrg | histidine-rich glycoprotein | 0.130 | |
| Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | 0.130 | |
| Slc12a1 | solute carrier family 12, member 1 | 0.124 | |
| Hgd | homogentisate 1, 2-dioxygenase | 0.118 | |
| Cyp2c29 | cytochrome P450, family 2, subfamily c, polypeptide 29 | 0.111 | |
| Elovl3 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | 0.102 | |
| Apoc4 | apolipoprotein C-IV | 0.094 | |
| Upp2 | uridine phosphorylase 2 | 0.093 | |
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.093 | |
| Mc2r | melanocortin 2 receptor | 0.091 | |
| Adra2b | adrenergic receptor, alpha 2b | 0.084 | |
| Hao2 | hydroxyacid oxidase 2 | 0.084 | |
| Aadat | aminoadipate aminotransferase | 0.075 | |
| Otc | ornithine transcarbamylase | 0.073 | |
| Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | 0.071 | |
| Bhmt | betaine-homocysteine methyltransferase | 0.071 | |
| Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.069 | |
| Afm | afamin | 0.069 | |
| Mep1a | meprin 1 alpha | 0.068 | |
| Cyp2d26 | cytochrome P450, family 2, subfamily d, polypeptide 26 | 0.067 | |
| Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | 0.066 | |
| F13b | coagulation factor XIII, beta subunit | 0.065 | |
| Ar | androgen receptor | 0.064 | |
| Slc27a5 | solute carrier family 27 (fatty acid transporter), member 5 | 0.064 | |
| Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 0.063 | |
| Serpina12 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | 0.062 | |
| Akr1c6 | aldo-keto reductase family 1, member C6 | 0.060 | |
| Abcc6 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | 0.059 | |
| Klk1b4 | kallikrein 1-related pepidase b4 | 0.058 | |
| Mug2 | murinoglobulin 2 | 0.057 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.056 | |
| Hoxd8 | homeobox D8 | 0.055 | |
| Apoh | apolipoprotein H | 0.055 | |
| Klkb1 | kallikrein B, plasma 1 | 0.053 | |
| Masp1 | mannan-binding lectin serine peptidase 1 | 0.050 | |
| Inhbc | inhibin beta-C | 0.048 | |
| Ces1g | carboxylesterase 1G | 0.048 | |
| Rdh7 | retinol dehydrogenase 7 | 0.047 | |
| Hsd17b2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.047 | |
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.045 | |
| Aqp8 | aquaporin 8 | 0.045 | |
| Tnp1 | transition protein 1 | 0.045 | |
| Crh | corticotropin releasing hormone | 0.044 | |
| Cyp3a25 | cytochrome P450, family 3, subfamily a, polypeptide 25 | 0.044 | |
| Aadac | arylacetamide deacetylase (esterase) | 0.043 | |
| Timd2 | T-cell immunoglobulin and mucin domain containing 2 | 0.043 | |
| Star | steroidogenic acute regulatory protein | 0.043 | |
| Tdo2 | tryptophan 2,3-dioxygenase | 0.042 | |
| Fshr | follicle stimulating hormone receptor | 0.041 | |
| Lox | lysyl oxidase | 0.041 | |
| Gsta2 | glutathione S-transferase, alpha 2 (Yc2) | 0.040 | |
| Agxt | alanine-glyoxylate aminotransferase | 0.040 | |
| Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 0.039 | |
| Rdh16 | retinol dehydrogenase 16 | 0.038 | |
| Cyp3a11 | cytochrome P450, family 3, subfamily a, polypeptide 11 | 0.038 | |
| Svs5 | seminal vesicle secretory protein 5 | 0.038 | |
| Acsm2 | acyl-CoA synthetase medium-chain family member 2 | 0.038 | |
| Dct | dopachrome tautomerase | 0.038 | |
| Sardh | sarcosine dehydrogenase | 0.037 | |
| Mup4 | major urinary protein 4 | 0.036 | |
| Fabp1 | fatty acid binding protein 1, liver | 0.036 | |
| Cyp2c38 | cytochrome P450, family 2, subfamily c, polypeptide 38 | 0.034 | |
| Apob | apolipoprotein B | 0.034 | |
| Cyp17a1 | cytochrome P450, family 17, subfamily a, polypeptide 1 | 0.033 | |
| Baat | bile acid-Coenzyme A: amino acid N-acyltransferase | 0.033 | |
| Enam | enamelin | 0.033 | |
| Slc26a1 | solute carrier family 26 (sulfate transporter), member 1 | 0.032 | |
| Azgp1 | alpha-2-glycoprotein 1, zinc | 0.031 | |
| Sult1b1 | sulfotransferase family 1B, member 1 | 0.031 | |
| Spam1 | sperm adhesion molecule 1 | 0.031 | |
| Dhh | desert hedgehog | 0.030 | |
| Prlr | prolactin receptor | 0.030 | |
| Fbp1 | fructose bisphosphatase 1 | 0.030 | |
| Serpina6 | serine (or cysteine) peptidase inhibitor, clade A, member 6 | 0.030 | |
| Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1 | 0.030 | |
| Foxc1 | forkhead box C1 | 0.030 | |
| Slc22a1 | solute carrier family 22 (organic cation transporter), member 1 | 0.030 | |
| Hnf4a | hepatic nuclear factor 4, alpha | 0.029 | |
| Lipc | lipase, hepatic | 0.029 | |
| Mas1 | MAS1 oncogene | 0.028 | |
| Car5a | carbonic anhydrase 5a, mitochondrial | 0.027 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Il1b | interleukin 1 beta | 0.186 | |
| Cyp2b1 | cytochrome P450, family 2, subfamily b, polypeptide 1 | 0.141 | |
| Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | 0.087 | |
| Hrh2 | histamine receptor H 2 | 0.077 | |
| Mmp12 | matrix metallopeptidase 12 | 0.073 | |
| Cyp4f1 | cytochrome P450, family 4, subfamily f, polypeptide 1 | 0.061 | |
| Sult1b1 | sulfotransferase family, cytosolic, 1B, member 1 | 0.058 | |
| Cops7a | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) | 0.058 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.058 | |
| Fabp6 | fatty acid binding protein 6, ileal | 0.052 | |
| Eef2 | eukaryotic translation elongation factor 2 | 0.041 | |
| Clca4 | chloride channel accessory 4 | 0.038 | |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.037 | |
| Gna12 | guanine nucleotide binding protein (G protein) alpha 12 | 0.032 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.029 | |
| Il6 | interleukin 6 | 0.028 | |
| LOC293989 | cytochrome P450-like | 0.028 | |
| Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 0.026 | |
| Bcl2a1d | B-cell leukemia/lymphoma 2 related protein A1d | 0.026 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.025 | |
| Hpd | 4-hydroxyphenylpyruvate dioxygenase | 0.025 | |
| Fcer1a | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.025 | |
| Slc9a2 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | 0.022 | |
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.022 | |
| Rgs1 | regulator of G-protein signaling 1 | 0.022 | |
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.020 | |
| Vip | vasoactive intestinal peptide | 0.019 | |
| Star | steroidogenic acute regulatory protein | 0.019 | |
| Sult2a1 | sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 0.019 | |
| Cd83 | CD83 molecule | 0.018 | |
| Cyp11a1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | 0.018 | |
| Gnb2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 0.018 | |
| Hcrtr2 | hypocretin (orexin) receptor 2 | 0.017 | |
| Cyp2c22 | cytochrome P450, family 2, subfamily c, polypeptide 22 | 0.017 | |
| Reg3b | regenerating islet-derived 3 beta | 0.017 | |
| Nkg7 | natural killer cell group 7 sequence | 0.016 | |
| Stat4 | signal transducer and activator of transcription 4 | 0.016 | |
| Csrp3 | cysteine and glycine-rich protein 3 | 0.016 | |
| Gna15 | guanine nucleotide binding protein, alpha 15 | 0.016 | |
| Sult1c3 | sulfotransferase family, cytosolic, 1C, member 3 | 0.016 | |
| Gabrg3 | gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 0.016 | |
| Dpep1 | dipeptidase 1 (renal) | 0.015 | |
| Dpp4 | dipeptidylpeptidase 4 | 0.015 | |
| Akr1c18 | aldo-keto reductase family 1, member C18 | 0.015 | |
| Gabre | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.015 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.015 | |
| Clec2d | C-type lectin domain family 2, member d | 0.014 | |
| Tacr2 | tachykinin receptor 2 | 0.014 | |
| Klk8 | kallikrein related-peptidase 8 | 0.014 | |
| F2rl2 | coagulation factor II (thrombin) receptor-like 2 | 0.014 | |
| Fbp1 | fructose-1,6-bisphosphatase 1 | 0.014 | |
| Dnahc6 | dynein, axonemal, heavy chain 6 | 0.013 | |
| Il1a | interleukin 1 alpha | 0.013 | |
| Ppard | peroxisome proliferator-activated receptor delta | 0.013 | |
| Gmeb2 | glucocorticoid modulatory element binding protein 2 | 0.013 | |
| Fcn1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.013 | |
| Bok | BCL2-related ovarian killer | 0.013 | |
| Dnase1l3 | deoxyribonuclease 1-like 3 | 0.012 | |
| Il2rb | interleukin 2 receptor, beta | 0.012 | |
| Cox6a2 | cytochrome c oxidase, subunit VIa, polypeptide 2 | 0.012 | |
| Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 0.012 | |
| Usf2 | upstream transcription factor 2, c-fos interacting | 0.012 | |
| Ceacam10 | carcinoembryonic antigen-related cell adhesion molecule 10 | 0.012 | |
| Rims1 | regulating synaptic membrane exocytosis 1 | 0.012 | |
| Cxcl1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.012 | |
| Gzmk | granzyme K | 0.012 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.011 | |
| ND4 | NADH dehydrogenase subunit 4 | 0.011 | |
| Gzmc | granzyme C | 0.011 | |
| Drd1a | dopamine receptor D1A | 0.011 | |
| Fabp1 | fatty acid binding protein 1, liver | 0.011 | |
| Syngr2 | synaptogyrin 2 | 0.011 | |
| Slc9a3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | 0.011 | |
| Sele | selectin E | 0.011 | |
| Slc12a1 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | 0.011 | |
| Gstm2 | glutathione S-transferase mu 2 | 0.011 | |
| Hsd17b2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.011 | |
| Guca2a | guanylate cyclase activator 2a (guanylin) | 0.010 | |
| Xcl1 | chemokine (C motif) ligand 1 | 0.010 |