The network for 'signal release' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal release

The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.

Name Description Probability Func Analog Organism
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.772
Glp1r glucagon-like peptide 1 receptor 0.768
Ins2 insulin 2 0.644
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.566
Rims1 regulating synaptic membrane exocytosis 1 0.542
Csf1 colony stimulating factor 1 (macrophage) 0.522
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.503
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.444
Phkg1 phosphorylase kinase, gamma 1 0.441
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.418
Fev FEV (ETS oncogene family) 0.412
Casp3 caspase 3 0.409
Prdm2 PR domain containing 2, with ZNF domain 0.405
Th tyrosine hydroxylase 0.395
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.391
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.386
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.378
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.372
Gper G protein-coupled estrogen receptor 1 0.367
Avp arginine vasopressin 0.367
Crhr1 corticotropin releasing hormone receptor 1 0.352
Nfasc neurofascin 0.346
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.344
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.331
Myt1l myelin transcription factor 1-like 0.323
Tshb thyroid stimulating hormone, beta 0.308
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.300
Vamp2 vesicle-associated membrane protein 2 0.298
Arrb1 arrestin, beta 1 0.298
Gnao1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.296
RGD1310262 hypothetical LOC304650 0.293
Anxa5 annexin A5 0.291
Prlhr prolactin releasing hormone receptor 0.290
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.281
Hpcal4 hippocalcin-like 4 0.281
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.274
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.270
Grm5 glutamate receptor, metabotropic 5 0.262
Kcnk3 potassium channel, subfamily K, member 3 0.262
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.260
Pomc proopiomelanocortin 0.258
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.256
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.250
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.247
Cxcr5 chemokine (C-X-C motif) receptor 5 0.245
Ush1c Usher syndrome 1C homolog (human) 0.245
Fam108b1 family with sequence similarity 108, member B1 0.239
Tnr tenascin R 0.238
Prss3 protease, serine, 3 0.236
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.235
Unc13c unc-13 homolog C (C. elegans) 0.235
Cnga4 cyclic nucleotide gated channel alpha 4 0.233
Neurod2 neurogenic differentiation 2 0.232
Cckbr cholecystokinin B receptor 0.227
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.227
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.227
Gabra6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.225
Ppyr1 pancreatic polypeptide receptor 1 0.224
Gabrd gamma-aminobutyric acid (GABA) A receptor, delta 0.223
Grm6 glutamate receptor, metabotropic 6 0.220
Unc5a unc-5 homolog A (C. elegans) 0.212
Serp1 stress-associated endoplasmic reticulum protein 1 0.209
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.208
Pecam1 platelet/endothelial cell adhesion molecule 1 0.206
Itgam integrin, alpha M 0.206
Lif leukemia inhibitory factor 0.205
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.200
Jak2 Janus kinase 2 0.199
Il23a Interleukin 23, alpha subunit p19 0.197
Cntn3 contactin 3 (plasmacytoma associated) 0.196
Dlg4 discs, large homolog 4 (Drosophila) 0.195
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.195
Prlr prolactin receptor 0.194
Acrv1 acrosomal vesicle protein 1 0.193
Prg2 proteoglycan 2, bone marrow 0.188
Pnpla8 patatin-like phospholipase domain containing 8 0.187
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.187
Psp parotid secretory protein 0.186
Rgs9 regulator of G-protein signaling 9 0.185
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.182
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.182
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.180
Tmem79 transmembrane protein 79 0.178
Pde3a phosphodiesterase 3A, cGMP inhibited 0.175
Slc24a2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.175
Tnp1 transition protein 1 0.174
Stx1a syntaxin 1A (brain) 0.173
Camkv CaM kinase-like vesicle-associated 0.172
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.172
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.171
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.171
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.170
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.169
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.167
Trhr2 thyrotropin releasing hormone receptor 2 0.165
Syt4 synaptotagmin IV 0.165
Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 0.164
Smgb neonatal submandibular gland protein B 0.164
Lin7c lin-7 homolog C (C. elegans) 0.163
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.163
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.590
pkg-1 Protein PKG-1 0.239
unc-13 Protein UNC-13 0.228
cyp-35C1 Protein CYP-35C1 0.218
goa-1 Protein GOA-1 0.191
egl-36 Protein EGL-36 0.190
nlg-1 Protein NLG-1 0.178
unc-32 Protein UNC-32 0.144
cyp-35A3 Protein CYP-35A3 0.092
pdfr-1 Protein PDFR-1 0.091
egl-5 Protein EGL-5 0.078
gar-3 Protein GAR-3 0.074
unc-54 Protein UNC-54 0.074
egl-26 Protein EGL-26 0.073
C33A11.1 Protein C33A11.1 0.073
unc-47 Protein UNC-47 0.072
eat-6 Protein EAT-6 0.070
egl-30 Protein EGL-30 0.067
F54G2.1 Protein F54G2.1 0.065
rpy-1 Protein RPY-1 0.059
unc-80 Protein UNC-80 0.059
unc-17 Protein UNC-17 0.058
ist-1 Protein IST-1 0.057
rpm-1 Protein RPM-1 0.057
nrx-1 Protein NRX-1 0.056
lin-11 Protein LIN-11 0.050
egl-23 Protein EGL-23 0.048
madd-4 Protein MADD-4 0.048
cal-4 Protein CAL-4 0.047
hlh-11 Protein HLH-11 0.046
cyp-35A2 Protein CYP-35A2 0.045
nhr-202 Protein NHR-202 0.044
cmd-1 Protein CMD-1 0.044
unc-10 Protein UNC-10 0.043
magi-1 Protein MAGI-1 0.043
frm-3 Protein FRM-3 0.042
pkn-1 Protein PKN-1 0.042
CELE_T13H5.1 Protein T13H5.1 0.040
eat-4 Protein EAT-4 0.040
nhr-122 Protein NHR-122 0.040
unc-79 Protein UNC-79 0.040
itr-1 Protein ITR-1 0.039
daf-1 Protein DAF-1 0.039
unc-53 Protein UNC-53 0.038
ugt-20 Protein UGT-20 0.038
clic-1 Protein CLIC-1 0.037
CELE_C29F7.2 Protein C29F7.2 0.036
mrp-1 Protein MRP-1 0.036
unc-36 Protein UNC-36 0.036
aat-5 Protein AAT-5 0.036
prkl-1 Protein PRKL-1 0.035
egl-3 Protein EGL-3 0.035
fbxc-5 Protein FBXC-5 0.035
inx-1 Protein INX-1 0.035
rskn-2 Protein RSKN-2 0.035
flt-1 Protein FLT-1 0.034
sng-1 Protein SNG-1 0.034
glr-5 Protein GLR-5 0.034
Y95B8A.12 Protein Y95B8A.12 0.033
let-23 Protein LET-23 0.033
vab-3 Protein VAB-3 0.033
cyp-35A5 Protein CYP-35A5 0.033
nra-3 Protein NRA-3 0.032
egl-15 Protein EGL-15 0.032
tbck-1 Protein TBCK-1 0.032
dyc-1 Protein DYC-1 0.032
snx-14 Protein SNX-14 0.032
daf-11 Protein DAF-11 0.032
unc-76 Protein UNC-76 0.031
trp-1 Protein TRP-1 0.031
gln-1 Protein GLN-1 0.031
rab-3 Protein RAB-3 0.031
dyb-1 Protein DYB-1 0.030
ida-1 Protein IDA-1 0.030
CELE_F28H1.1 Protein F28H1.1 0.029
attf-4 Protein ATTF-4 0.028
unc-49 Protein UNC-49 0.028
B0491.5 Protein B0491.5 0.028
ntl-4 Protein NTL-4 0.028
pes-7 Protein PES-7 0.028
lin-40 Protein LIN-40 0.027
plc-1 Protein PLC-1 0.027
lin-10 Protein LIN-10 0.027
K02F2.5 Protein K02F2.5 0.027
T23B12.6 Protein T23B12.6 0.027
T05F1.11 Protein T05F1.11 0.026
flp-7 Protein FLP-7 0.026
myo-6 Protein MYO-6 0.026
cit-1.2 Protein CIT-1.2 0.026
F44A2.5 Protein F44A2.5 0.026
F28E10.1 Protein F28E10.1 0.026
oig-1 Protein OIG-1 0.025
C06G3.6 Protein C06G3.6 0.025
mab-9 Protein MAB-9 0.025
egl-27 Protein EGL-27 0.025
grk-2 Protein GRK-2 0.024
M04C3.1 Protein M04C3.1 0.024
ztf-17 Protein ZTF-17 0.024
F10C2.3 Protein F10C2.3 0.023
unc-11 Protein UNC-11 0.023
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
GluRIIA Glutamate receptor IIA 1.000
CaMKII Calcium/calmodulin-dependent protein kinase II 0.984
brp bruchpilot 0.982
nej nejire 0.976
wit wishful thinking 0.961
fz2 frizzled 2 0.934
Syt1 Synaptotagmin 1 0.829
Snap25 Synapse protein 25 0.827
wls wntless 0.805
comt comatose 0.780
par-1 CG8201 gene product from transcript CG8201-RA 0.779
hth homothorax 0.777
Pka-C1 cAMP-dependent protein kinase 1 0.776
norpA no receptor potential A 0.751
KaiRIA CG18039 gene product from transcript CG18039-RA 0.739
bsk basket 0.693
unc-13 CG2999 gene product from transcript CG2999-RA 0.667
disco disconnected 0.665
Frq1 Frequenin 1 0.664
hiw highwire 0.626
unc-104 CG8566 gene product from transcript CG8566-RB 0.616
rtGEF rho-type guanine exchange factor 0.587
Nrx-1 Neurexin 1 0.559
pum pumilio 0.506
Rala Ras-related protein 0.503
Catsup Catecholamines up 0.486
CkIIalpha Casein kinase II alpha subunit 0.478
Ace Acetylcholine esterase 0.474
faf fat facets 0.431
Dab Disabled 0.421
stj straightjacket 0.401
slo slowpoke 0.400
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.393
CG31146 CG31146 gene product from transcript CG31146-RD 0.388
mnb minibrain 0.383
gbb glass bottom boat 0.362
HDAC6 CG6170 gene product from transcript CG6170-RA 0.361
neuroligin CG13772 gene product from transcript CG13772-RA 0.358
cv-c crossveinless c 0.329
shi shibire 0.329
Actbeta Activin-beta 0.300
cpx complexin 0.290
Lrrk Leucine-rich repeat kinase 0.289
Syx1A Syntaxin 1A 0.283
Cip4 CG15015 gene product from transcript CG15015-RA 0.279
Frq2 Frequenin 2 0.262
G-oalpha47A G protein oalpha 47A 0.253
CanA1 Calcineurin A1 0.249
Ank2 Ankyrin 2 0.244
alpha-Spec alpha Spectrin 0.235
eys eyes shut 0.233
Shaw Shaker cognate w 0.229
Dap160 Dynamin associated protein 160 0.227
Khc-73 Kinesin-73 0.207
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.202
Src64B Src oncogene at 64B 0.202
Tbh Tyramine beta hydroxylase 0.193
ci cubitus interruptus 0.191
AdoR Adenosine receptor 0.190
Snap Soluble NSF attachment protein 0.184
dco discs overgrown 0.183
spas spastin 0.178
VAChT CG32848 gene product from transcript CG32848-RA 0.178
n-syb n-synaptobrevin 0.167
p24-1 p24-related-1 0.163
Ork1 Open rectifier K[+] channel 1 0.163
CG34139 CG34139 gene product from transcript CG34139-RD 0.157
Cdk5alpha Cdk5 activator-like protein 0.157
Clk Clock 0.156
dys dysfusion 0.145
Imp IGF-II mRNA-binding protein 0.145
Pgk Phosphoglycerate kinase 0.144
Smg1 CG32743 gene product from transcript CG32743-RA 0.137
gfA giant fibre A 0.135
p24-2 p24-related-2 0.128
Eip63F-1 Ecdysone-induced protein 63F 1 0.127
Sema-1a CG18405 gene product from transcript CG18405-RD 0.125
dnc dunce 0.125
lap like-AP180 0.125
G-salpha60A G protein salpha 60A 0.122
tomosyn CG17762 gene product from transcript CG17762-RB 0.122
fusl fuseless 0.119
Unc-76 CG3981 gene product from transcript CG3981-RB 0.119
Ser Serrate 0.119
CG32635 CG32635 gene product from transcript CG32635-RA 0.117
shn schnurri 0.113
pAbp polyA-binding protein 0.113
CG34400 CG34400 gene product from transcript CG34400-RD 0.112
Nrg Neuroglian 0.112
Syb Synaptobrevin 0.111
lin lines 0.110
Plc21C Phospholipase C at 21C 0.108
E23 Early gene at 23 0.107
bai baiser 0.107
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.104
stmA stambha A 0.103
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.101
NFAT NFAT homolog 0.098
Src42A Src oncogene at 42A 0.097
cac cacophony 0.095
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Homo sapiens
Name Description Probability Func Analog Organism
SNAP23 synaptosomal-associated protein, 23kDa 0.895
PDX1 pancreatic and duodenal homeobox 1 0.894
ZFYVE9 zinc finger, FYVE domain containing 9 0.887
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.870
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.864
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 0.849
TEK TEK tyrosine kinase, endothelial 0.825
C1QA complement component 1, q subcomponent, A chain 0.819
DRD2 dopamine receptor D2 0.804
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.804
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.782
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.758
SMAD2 SMAD family member 2 0.734
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.728
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.699
EP300 E1A binding protein p300 0.689
HNF4A hepatocyte nuclear factor 4, alpha 0.677
EGFR epidermal growth factor receptor 0.611
GSK3B glycogen synthase kinase 3 beta 0.581
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.567
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.566
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.561
CCR5 chemokine (C-C motif) receptor 5 0.529
SNAP25 synaptosomal-associated protein, 25kDa 0.498
HSPA1B heat shock 70kDa protein 1B 0.496
CRHR1 corticotropin releasing hormone receptor 1 0.489
CAPNS1 calpain, small subunit 1 0.484
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.479
FGA fibrinogen alpha chain 0.479
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.473
ATN1 atrophin 1 0.472
FGB fibrinogen beta chain 0.469
IGF1R insulin-like growth factor 1 receptor 0.456
CCL4 chemokine (C-C motif) ligand 4 0.450
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.425
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.423
PRKCA protein kinase C, alpha 0.405
ARRB1 arrestin, beta 1 0.379
VIM vimentin 0.368
MPDZ multiple PDZ domain protein 0.354
CCNY cyclin Y 0.345
KAT2B K(lysine) acetyltransferase 2B 0.340
OCRL oculocerebrorenal syndrome of Lowe 0.335
MT1A metallothionein 1A 0.330
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.325
FBLN1 fibulin 1 0.307
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.301
STX5 syntaxin 5 0.294
NEUROD1 neurogenic differentiation 1 0.294
LIN7B lin-7 homolog B (C. elegans) 0.277
CHD8 chromodomain helicase DNA binding protein 8 0.272
HSPA1A heat shock 70kDa protein 1A 0.256
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.256
GATA4 GATA binding protein 4 0.249
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.247
CLASP1 cytoplasmic linker associated protein 1 0.246
PSEN2 presenilin 2 (Alzheimer disease 4) 0.244
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.238
DLG4 discs, large homolog 4 (Drosophila) 0.229
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.225
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.225
SREBF2 sterol regulatory element binding transcription factor 2 0.223
BLNK B-cell linker 0.221
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.213
CCL8 chemokine (C-C motif) ligand 8 0.213
MAPT microtubule-associated protein tau 0.211
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.211
ADORA2A adenosine A2a receptor 0.207
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.201
KIF5B kinesin family member 5B 0.200
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.198
HLA-DMA major histocompatibility complex, class II, DM alpha 0.191
NKX2-1 NK2 homeobox 1 0.187
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.183
CRH corticotropin releasing hormone 0.182
CXCL9 chemokine (C-X-C motif) ligand 9 0.182
IL1R1 interleukin 1 receptor, type I 0.181
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.176
YY1 YY1 transcription factor 0.174
MARCO macrophage receptor with collagenous structure 0.173
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.173
ONECUT1 one cut homeobox 1 0.170
C1QC complement component 1, q subcomponent, C chain 0.170
ESRRG estrogen-related receptor gamma 0.169
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.169
HTT huntingtin 0.169
CDX2 caudal type homeobox 2 0.165
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.165
HLA-DRA major histocompatibility complex, class II, DR alpha 0.163
ARRB2 arrestin, beta 2 0.162
SSTR2 somatostatin receptor 2 0.161
C1QB complement component 1, q subcomponent, B chain 0.158
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.155
WIPF1 WAS/WASL interacting protein family, member 1 0.153
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.150
LAT linker for activation of T cells 0.146
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.146
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.146
IL8 interleukin 8 0.145
NSF N-ethylmaleimide-sensitive factor 0.145
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism