IMP

Process View

Homo sapiens

28 genes annotated in human

Multi-species View

cholesterol homeostasis

GO:0042632

Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cholesterol homeostasis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cholesterol homeostasis" (in gray)

Name	Description	Probability	Func Analog Organism
HNF4A	hepatocyte nuclear factor 4, alpha	0.999	Mouse
APOA1	apolipoprotein A-I	0.978
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.975
ALB	albumin	0.931
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.887
ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	0.834
A2M	alpha-2-macroglobulin	0.782
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.705
LDLR	low density lipoprotein receptor	0.687
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.661
PROX1	prospero homeobox 1	0.600
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.552
RRAGC	Ras-related GTP binding C	0.510
APOC1	apolipoprotein C-I	0.452
LRP1	low density lipoprotein receptor-related protein 1	0.439	Human
CRP	C-reactive protein, pentraxin-related	0.419
PPARA	peroxisome proliferator-activated receptor alpha	0.408
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.382
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.349	Human
SEC24D	SEC24 family, member D (S. cerevisiae)	0.288
APOA2	apolipoprotein A-II	0.255
APOE	apolipoprotein E	0.241
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.230
FGA	fibrinogen alpha chain	0.223
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.221
CREBBP	CREB binding protein	0.209
APOC2	apolipoprotein C-II	0.197
HR	hairless homolog (mouse)	0.190
C7orf59	chromosome 7 open reading frame 59	0.167
SKIL	SKI-like oncogene	0.163
ITGB5	integrin, beta 5	0.160
RRAGA	Ras-related GTP binding A	0.159
ANKFY1	ankyrin repeat and FYVE domain containing 1	0.148
LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	0.129
PTPRF	protein tyrosine phosphatase, receptor type, F	0.129
MASP2	mannan-binding lectin serine peptidase 2	0.120
CAV2	caveolin 2	0.113
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.109
APOB	apolipoprotein B (including Ag(x) antigen)	0.105
HIPK2	homeodomain interacting protein kinase 2	0.097
C14orf1	chromosome 14 open reading frame 1	0.096
HP	haptoglobin	0.087
PCSK9	proprotein convertase subtilisin/kexin type 9	0.085
RPL18A	ribosomal protein L18a	0.083
MBL2	mannose-binding lectin (protein C) 2, soluble	0.073
LCAT	lecithin-cholesterol acyltransferase	0.072
CAPRIN2	caprin family member 2	0.072
MTAP	methylthioadenosine phosphorylase	0.067
ABCF3	ATP-binding cassette, sub-family F (GCN20), member 3	0.066
INSIG1	insulin induced gene 1	0.064
SCP2	sterol carrier protein 2	0.064
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.060
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.060
DHCR7	7-dehydrocholesterol reductase	0.060
APCS	amyloid P component, serum	0.058
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.057
BRI3	brain protein I3	0.056
NCOA1	nuclear receptor coactivator 1	0.055
STX12	syntaxin 12	0.054
PPARG	peroxisome proliferator-activated receptor gamma	0.053
APP	amyloid beta (A4) precursor protein	0.047
TRAF5	TNF receptor-associated factor 5	0.044
RXRA	retinoid X receptor, alpha	0.044
MSTO1	misato homolog 1 (Drosophila)	0.044
SQLE	squalene epoxidase	0.042
KAT2B	K(lysine) acetyltransferase 2B	0.041
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.041
APOC3	apolipoprotein C-III	0.039
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.039
MAP2K3	mitogen-activated protein kinase kinase 3	0.036
MICALL1	MICAL-like 1	0.036
SREBF1	sterol regulatory element binding transcription factor 1	0.036
F11	coagulation factor XI	0.034
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.034	Fly
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.032
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.032
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.030
PRCP	prolylcarboxypeptidase (angiotensinase C)	0.030
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.030
AMBP	alpha-1-microglobulin/bikunin precursor	0.029
EP300	E1A binding protein p300	0.028
MDK	midkine (neurite growth-promoting factor 2)	0.028
EPS8	epidermal growth factor receptor pathway substrate 8	0.028
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.028
PLTP	phospholipid transfer protein	0.027
EBP	emopamil binding protein (sterol isomerase)	0.027
EHD4	EH-domain containing 4	0.027
SREBF2	sterol regulatory element binding transcription factor 2	0.026	Mouse
STON2	stonin 2	0.026
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.026
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.025
MVD	mevalonate (diphospho) decarboxylase	0.024
YIPF5	Yip1 domain family, member 5	0.024
RNASEK	ribonuclease, RNase K	0.024
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.023
CD63	CD63 molecule	0.023
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.023	Fly
KNG1	kininogen 1	0.023
MAT1A	methionine adenosyltransferase I, alpha	0.022
DAB1	disabled homolog 1 (Drosophila)	0.022
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.021
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.021
HPD	4-hydroxyphenylpyruvate dioxygenase	0.021
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.021
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.021
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.021
SMAD2	SMAD family member 2	0.021
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.020
STK10	serine/threonine kinase 10	0.020
THPO	thrombopoietin	0.020
ALDOB	aldolase B, fructose-bisphosphate	0.020
TGFA	transforming growth factor, alpha	0.020
PRKCA	protein kinase C, alpha	0.020
CREB3L2	cAMP responsive element binding protein 3-like 2	0.020
LOXL4	lysyl oxidase-like 4	0.019
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.018
CDK9	cyclin-dependent kinase 9	0.018
FOXO3	forkhead box O3	0.018
CA5A	carbonic anhydrase VA, mitochondrial	0.018
FCHO2	FCH domain only 2	0.018
HEXB	hexosaminidase B (beta polypeptide)	0.017
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	0.017
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.017
ACBD3	acyl-CoA binding domain containing 3	0.017
MAGEB18	melanoma antigen family B, 18	0.017
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.017
PID1	phosphotyrosine interaction domain containing 1	0.017
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.016
C1QB	complement component 1, q subcomponent, B chain	0.016
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.016
SEC23A	Sec23 homolog A (S. cerevisiae)	0.016
WNT3A	wingless-type MMTV integration site family, member 3A	0.016
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.016
SC4MOL	sterol-C4-methyl oxidase-like	0.016
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.016
GLYAT	glycine-N-acyltransferase	0.015
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.015
ADH6	alcohol dehydrogenase 6 (class V)	0.015
APOA5	apolipoprotein A-V	0.015
GJB1	gap junction protein, beta 1, 32kDa	0.015
EGF	epidermal growth factor	0.015	Human
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.015
ANXA4	annexin A4	0.015
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.014
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.014
G6PC	glucose-6-phosphatase, catalytic subunit	0.014
RRAGD	Ras-related GTP binding D	0.014
C8A	complement component 8, alpha polypeptide	0.014
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.014
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.014
NCOR2	nuclear receptor corepressor 2	0.014
CTSH	cathepsin H	0.014
FAM83C	family with sequence similarity 83, member C	0.013
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.013
CDHR5	cadherin-related family member 5	0.013
VAV2	vav 2 guanine nucleotide exchange factor	0.013
FABP1	fatty acid binding protein 1, liver	0.013
GPNMB	glycoprotein (transmembrane) nmb	0.013
BHMT	betaine--homocysteine S-methyltransferase	0.013
LITAF	lipopolysaccharide-induced TNF factor	0.013
CXXC5	CXXC finger protein 5	0.013
ITIH2	inter-alpha (globulin) inhibitor H2	0.013
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.013
SART1	squamous cell carcinoma antigen recognized by T cells	0.013
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.013
CCDC115	coiled-coil domain containing 115	0.013
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.013
MTTP	microsomal triglyceride transfer protein	0.013
RRAS	related RAS viral (r-ras) oncogene homolog	0.012
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.012
PEX13	peroxisomal biogenesis factor 13	0.012
DHCR24	24-dehydrocholesterol reductase	0.012
C8G	complement component 8, gamma polypeptide	0.012
GM2A	GM2 ganglioside activator	0.012
CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	0.012
HABP2	hyaluronan binding protein 2	0.012
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.012
PDIA3	protein disulfide isomerase family A, member 3	0.012
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.012
APLP2	amyloid beta (A4) precursor-like protein 2	0.012
TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)	0.012
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.012
ZG16	zymogen granule protein 16 homolog (rat)	0.012
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.012
AFP	alpha-fetoprotein	0.011
OTC	ornithine carbamoyltransferase	0.011
F9	coagulation factor IX	0.011
ITGB4	integrin, beta 4	0.011
LGALS3	lectin, galactoside-binding, soluble, 3	0.011
HADH	hydroxyacyl-CoA dehydrogenase	0.011
LNX1	ligand of numb-protein X 1	0.011
SIAH1	seven in absentia homolog 1 (Drosophila)	0.011
AQP8	aquaporin 8	0.011
F13B	coagulation factor XIII, B polypeptide	0.011
EPHB4	EPH receptor B4	0.011
FADS1	fatty acid desaturase 1	0.011
TNK2	tyrosine kinase, non-receptor, 2	0.011
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.011
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.011
DUSP23	dual specificity phosphatase 23	0.011
APOC4	apolipoprotein C-IV	0.011
JMJD6	jumonji domain containing 6	0.011
NFYC	nuclear transcription factor Y, gamma	0.011
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.011
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.011
SCARB1	scavenger receptor class B, member 1	0.011	Mouse
BCL6	B-cell CLL/lymphoma 6	0.011
ASGR2	asialoglycoprotein receptor 2	0.011
TMEM59	transmembrane protein 59	0.010
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.010
C4BPB	complement component 4 binding protein, beta	0.010
RAB4A	RAB4A, member RAS oncogene family	0.010
TRIM15	tripartite motif containing 15	0.010
EPHA2	EPH receptor A2	0.010
LBP	lipopolysaccharide binding protein	0.010
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.010
GSK3B	glycogen synthase kinase 3 beta	0.010
FASN	fatty acid synthase	0.010
ADHFE1	alcohol dehydrogenase, iron containing, 1	0.010
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.010
RIBC2	RIB43A domain with coiled-coils 2	0.010
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.010