IMP

Process View

Homo sapiens

21 genes annotated in human

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "acute inflammatory response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "acute inflammatory response" (in gray)

Name	Description	Probability	Func Analog Organism
IL8	interleukin 8	0.996
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.937	Rat
CXCL2	chemokine (C-X-C motif) ligand 2	0.929	Rat
IL1B	interleukin 1, beta	0.844	Human Mouse Rat
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.826	Mouse Rat
C1S	complement component 1, s subcomponent	0.825	Human
ICAM1	intercellular adhesion molecule 1	0.745
CXCL3	chemokine (C-X-C motif) ligand 3	0.693	Rat
IL1R1	interleukin 1 receptor, type I	0.643
C3	complement component 3	0.626	Human Mouse
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.586
C1R	complement component 1, r subcomponent	0.577	Human
IL6	interleukin 6 (interferon, beta 2)	0.423
S100A9	S100 calcium binding protein A9	0.325
CCL2	chemokine (C-C motif) ligand 2	0.285
CCL20	chemokine (C-C motif) ligand 20	0.272
RIPK2	receptor-interacting serine-threonine kinase 2	0.208
PLAUR	plasminogen activator, urokinase receptor	0.140
BBS10	Bardet-Biedl syndrome 10	0.136
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.135
SYK	spleen tyrosine kinase	0.135
ALB	albumin	0.132
SOD2	superoxide dismutase 2, mitochondrial	0.124
CCR5	chemokine (C-C motif) receptor 5	0.120
TSC1	tuberous sclerosis 1	0.116
CFH	complement factor H	0.106	Mouse Rat
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.096
HP	haptoglobin	0.087
IL1R2	interleukin 1 receptor, type II	0.081
APOE	apolipoprotein E	0.075
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.075
IER3	immediate early response 3	0.074
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.065
UBASH3B	ubiquitin associated and SH3 domain containing B	0.065
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.064
MASP2	mannan-binding lectin serine peptidase 2	0.061	Human
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.058
KNG1	kininogen 1	0.058
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.058
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.056
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.054
JUP	junction plakoglobin	0.051
COTL1	coactosin-like 1 (Dictyostelium)	0.051
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.050	Mouse
DERL1	Der1-like domain family, member 1	0.050
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.050
ALOX5	arachidonate 5-lipoxygenase	0.049	Rat
APCS	amyloid P component, serum	0.049
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.047
CXCL5	chemokine (C-X-C motif) ligand 5	0.047
CFHR1	complement factor H-related 1	0.046
ITGB1BP3	integrin beta 1 binding protein 3	0.045
C8B	complement component 8, beta polypeptide	0.044
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.043
C8A	complement component 8, alpha polypeptide	0.041
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.039
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.039
CFI	complement factor I	0.038
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.038
PLEK	pleckstrin	0.037
SRGN	serglycin	0.036
ADORA2A	adenosine A2a receptor	0.035
S100A8	S100 calcium binding protein A8	0.033	Rat
PLG	plasminogen	0.033	Human
NAMPT	nicotinamide phosphoribosyltransferase	0.032
CXCL10	chemokine (C-X-C motif) ligand 10	0.031
S100A12	S100 calcium binding protein A12	0.031
SAT1	spermidine/spermine N1-acetyltransferase 1	0.030
ENO2	enolase 2 (gamma, neuronal)	0.030
BCL2A1	BCL2-related protein A1	0.030
GAST	gastrin	0.030
PI3	peptidase inhibitor 3, skin-derived	0.029
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.028
CCL8	chemokine (C-C motif) ligand 8	0.027
CCL4	chemokine (C-C motif) ligand 4	0.027
SAA4	serum amyloid A4, constitutive	0.026
BLNK	B-cell linker	0.026
TF	transferrin	0.026	Rat
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.025
HCK	hemopoietic cell kinase	0.024
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.022
CFB	complement factor B	0.022
NNMT	nicotinamide N-methyltransferase	0.022
IL1RAP	interleukin 1 receptor accessory protein	0.022
TLR2	toll-like receptor 2	0.022
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.022
IL1RN	interleukin 1 receptor antagonist	0.022
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.022
B2M	beta-2-microglobulin	0.022
EMP1	epithelial membrane protein 1	0.022
IL6R	interleukin 6 receptor	0.021
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.021
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.021
LBP	lipopolysaccharide binding protein	0.021
IFNGR1	interferon gamma receptor 1	0.021
ARG1	arginase, liver	0.020
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.020
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.020
C4BPA	complement component 4 binding protein, alpha	0.020
C1orf93	chromosome 1 open reading frame 93	0.019
HNF4A	hepatocyte nuclear factor 4, alpha	0.019
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.019	Rat
ITIH1	inter-alpha (globulin) inhibitor H1	0.019	Human
IGFBP3	insulin-like growth factor binding protein 3	0.019
C7	complement component 7	0.019
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.019
SELE	selectin E	0.018
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.018
PTX3	pentraxin 3, long	0.018
GPR109B	G protein-coupled receptor 109B	0.018
KYNU	kynureninase	0.018
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.017
C2	complement component 2	0.017
TYROBP	TYRO protein tyrosine kinase binding protein	0.017
CPD	carboxypeptidase D	0.017
G0S2	G0/G1switch 2	0.017
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.016
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.016
APOB	apolipoprotein B (including Ag(x) antigen)	0.016
SLA	Src-like-adaptor	0.016
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.016
SOCS3	suppressor of cytokine signaling 3	0.016
CD14	CD14 molecule	0.016
AQP9	aquaporin 9	0.016
CCL22	chemokine (C-C motif) ligand 22	0.016
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.015
CFHR2	complement factor H-related 2	0.015
ITIH2	inter-alpha (globulin) inhibitor H2	0.015	Human
CPN1	carboxypeptidase N, polypeptide 1	0.015
STAT5A	signal transducer and activator of transcription 5A	0.015
INSR	insulin receptor	0.015
ESR1	estrogen receptor 1	0.015
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.015
DCN	decorin	0.014
PLSCR4	phospholipid scramblase 4	0.014
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.014
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.014
HRG	histidine-rich glycoprotein	0.014
CAV1	caveolin 1, caveolae protein, 22kDa	0.014
MBL2	mannose-binding lectin (protein C) 2, soluble	0.014
SLPI	secretory leukocyte peptidase inhibitor	0.014
IL2RB	interleukin 2 receptor, beta	0.014
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.013
SELL	selectin L	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.013
IL10	interleukin 10	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013
CD164	CD164 molecule, sialomucin	0.013
SPP2	secreted phosphoprotein 2, 24kDa	0.013
FN1	fibronectin 1	0.013
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.013
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.013
PICALM	phosphatidylinositol binding clathrin assembly protein	0.013
CLEC7A	C-type lectin domain family 7, member A	0.013
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.013
FERMT3	fermitin family member 3	0.013
NCF2	neutrophil cytosolic factor 2	0.012
CPN2	carboxypeptidase N, polypeptide 2	0.012
CH25H	cholesterol 25-hydroxylase	0.012
HPX	hemopexin	0.012
CCL16	chemokine (C-C motif) ligand 16	0.012
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.012
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.012	Human
JAK1	Janus kinase 1	0.012
CPA3	carboxypeptidase A3 (mast cell)	0.012
FPR2	formyl peptide receptor 2	0.012
CP	ceruloplasmin (ferroxidase)	0.012
BIRC3	baculoviral IAP repeat containing 3	0.012
F13A1	coagulation factor XIII, A1 polypeptide	0.011
CSF1	colony stimulating factor 1 (macrophage)	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011
HABP2	hyaluronan binding protein 2	0.011	Human
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.011
LECT2	leukocyte cell-derived chemotaxin 2	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.011
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.011
CTSG	cathepsin G	0.011
PYDC2	pyrin domain containing 2	0.011
DPT	dermatopontin	0.011
NOV	nephroblastoma overexpressed gene	0.011
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.011
THBD	thrombomodulin	0.010
LIPC	lipase, hepatic	0.010
LCN2	lipocalin 2	0.010
F11	coagulation factor XI	0.010
TM9SF2	transmembrane 9 superfamily member 2	0.010
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.010
IGF1	insulin-like growth factor 1 (somatomedin C)	0.010	Human
CSF3	colony stimulating factor 3 (granulocyte)	0.010
FPR1	formyl peptide receptor 1	0.010
WDYHV1	WDYHV motif containing 1	0.010
STOM	stomatin	0.010
CCL11	chemokine (C-C motif) ligand 11	0.010
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.010
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.010
TP53BP1	tumor protein p53 binding protein 1	0.010
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.010
CCR1	chemokine (C-C motif) receptor 1	0.010
LYZ	lysozyme	0.010
MRC1	mannose receptor, C type 1	0.010
C4BPB	complement component 4 binding protein, beta	0.010