IMP

Process View

Homo sapiens

7 genes annotated in human

Multi-species View

negative regulation of humoral immune response

GO:0002921

Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of humoral immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of humoral immune response" (in gray)

Name	Description	Probability	Func Analog Organism
JUN	jun proto-oncogene	0.999	Fly
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.999
C1R	complement component 1, r subcomponent	0.998	Human
JUNB	jun B proto-oncogene	0.996	Fly
C1S	complement component 1, s subcomponent	0.995	Human
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.964
ATF3	activating transcription factor 3	0.961
IL4R	interleukin 4 receptor	0.948
DUSP1	dual specificity phosphatase 1	0.934
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.686
XIAP	X-linked inhibitor of apoptosis	0.617
SYK	spleen tyrosine kinase	0.608
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.554
IER2	immediate early response 2	0.544
APOE	apolipoprotein E	0.468
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.467
EPOR	erythropoietin receptor	0.316
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.314
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.247
CFI	complement factor I	0.221
MAPK14	mitogen-activated protein kinase 14	0.198	Fly
ATF2	activating transcription factor 2	0.196
SOCS3	suppressor of cytokine signaling 3	0.178
CPNE6	copine VI (neuronal)	0.172
CFH	complement factor H	0.153
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.145
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.107
JUND	jun D proto-oncogene	0.096	Fly
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.075
DDIT3	DNA-damage-inducible transcript 3	0.072
INSR	insulin receptor	0.058
KLF6	Kruppel-like factor 6	0.058
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.055
EGR1	early growth response 1	0.055
STAP2	signal transducing adaptor family member 2	0.054
CAV1	caveolin 1, caveolae protein, 22kDa	0.047
TMEM173	transmembrane protein 173	0.043
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.042
PKN1	protein kinase N1	0.040
UBASH3B	ubiquitin associated and SH3 domain containing B	0.040
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.040
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.036
KLF4	Kruppel-like factor 4 (gut)	0.036
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.034
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.032
MAPK15	mitogen-activated protein kinase 15	0.032
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.030
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.030
CFB	complement factor B	0.029
MASP2	mannan-binding lectin serine peptidase 2	0.027	Human
DUSP9	dual specificity phosphatase 9	0.026
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.026
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.023
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.023
IL2RB	interleukin 2 receptor, beta	0.022
LCK	lymphocyte-specific protein tyrosine kinase	0.022
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.020
ITGB1BP1	integrin beta 1 binding protein 1	0.019
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.019
CD33	CD33 molecule	0.019
MAVS	mitochondrial antiviral signaling protein	0.019
DCN	decorin	0.018
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.017
PILRA	paired immunoglobin-like type 2 receptor alpha	0.016
UROD	uroporphyrinogen decarboxylase	0.016
EIF1	eukaryotic translation initiation factor 1	0.015
CD22	CD22 molecule	0.014
HP	haptoglobin	0.014
CD164	CD164 molecule, sialomucin	0.014
PLTP	phospholipid transfer protein	0.014
BTG2	BTG family, member 2	0.013
RBM8A	RNA binding motif protein 8A	0.013
ZFAND5	zinc finger, AN1-type domain 5	0.013
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.013
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.013
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.013
C1QA	complement component 1, q subcomponent, A chain	0.012
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.012
CP	ceruloplasmin (ferroxidase)	0.012
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.012
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.012
SH3BP2	SH3-domain binding protein 2	0.011
GADD45B	growth arrest and DNA-damage-inducible, beta	0.011
PLG	plasminogen	0.010
STAT5B	signal transducer and activator of transcription 5B	0.010	Fly
VSIG4	V-set and immunoglobulin domain containing 4	0.010
USP20	ubiquitin specific peptidase 20	0.010
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.010	Mouse
JAK2	Janus kinase 2	0.010