IMP

Process View

Homo sapiens

12 genes annotated in human

Multi-species View

apoptotic cell clearance

GO:0043277

The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "apoptotic cell clearance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "apoptotic cell clearance" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.992
FN1	fibronectin 1	0.978
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.722	Worm
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.657
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.626
SH3KBP1	SH3-domain kinase binding protein 1	0.538
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.491
EGFR	epidermal growth factor receptor	0.405
RXRA	retinoid X receptor, alpha	0.313
ANXA1	annexin A1	0.312	Worm
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.305
PXN	paxillin	0.291
SNX6	sorting nexin 6	0.281
FGF1	fibroblast growth factor 1 (acidic)	0.277
CFLAR	CASP8 and FADD-like apoptosis regulator	0.234
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.217
FASLG	Fas ligand (TNF superfamily, member 6)	0.187	Fly
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.186
GRB2	growth factor receptor-bound protein 2	0.156
AXL	AXL receptor tyrosine kinase	0.150	Mouse
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.149
MAP2K4	mitogen-activated protein kinase kinase 4	0.142
ATF2	activating transcription factor 2	0.138
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.122
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.121
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.117
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.109
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.097
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.095	Worm
MAPK8	mitogen-activated protein kinase 8	0.091	Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.090
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.083
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.082	Worm
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.081
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.079
LAT	linker for activation of T cells	0.072
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.071
GAS6	growth arrest-specific 6	0.069
JUN	jun proto-oncogene	0.068
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.066
VIM	vimentin	0.063
ABI1	abl-interactor 1	0.056	Worm
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.055
RAB1A	RAB1A, member RAS oncogene family	0.052
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.050
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.048
FGFR1	fibroblast growth factor receptor 1	0.044	Worm
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.044	Worm
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.042
ADAM19	ADAM metallopeptidase domain 19	0.040
PDCD6IP	programmed cell death 6 interacting protein	0.039
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.038	Worm
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.037
FGFR2	fibroblast growth factor receptor 2	0.036	Worm
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.036
RHOA	ras homolog gene family, member A	0.036
SLMAP	sarcolemma associated protein	0.034
RARA	retinoic acid receptor, alpha	0.033
RAB7A	RAB7A, member RAS oncogene family	0.033
MED25	mediator complex subunit 25	0.032
DYNLT3	dynein, light chain, Tctex-type 3	0.031
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.031
ITGB5	integrin, beta 5	0.030
APOE	apolipoprotein E	0.030
ANXA2	annexin A2	0.030	Worm
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.030
FNBP1	formin binding protein 1	0.029
SESN2	sestrin 2	0.029
PICALM	phosphatidylinositol binding clathrin assembly protein	0.029
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.028	Worm
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.027
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.027
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.027
NXF1	nuclear RNA export factor 1	0.026
IQGAP1	IQ motif containing GTPase activating protein 1	0.026
SOS1	son of sevenless homolog 1 (Drosophila)	0.025
KIF5B	kinesin family member 5B	0.024
CTGF	connective tissue growth factor	0.024
NCKAP1	NCK-associated protein 1	0.023
RB1CC1	RB1-inducible coiled-coil 1	0.023
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.023
FAS	Fas (TNF receptor superfamily, member 6)	0.022
APP	amyloid beta (A4) precursor protein	0.022
EPS8	epidermal growth factor receptor pathway substrate 8	0.022
NAV1	neuron navigator 1	0.021
WASL	Wiskott-Aldrich syndrome-like	0.021
FADD	Fas (TNFRSF6)-associated via death domain	0.021
BCOR	BCL6 corepressor	0.021
MAPK6	mitogen-activated protein kinase 6	0.020
FYN	FYN oncogene related to SRC, FGR, YES	0.020
ADAM15	ADAM metallopeptidase domain 15	0.020
SETDB1	SET domain, bifurcated 1	0.018
PDHX	pyruvate dehydrogenase complex, component X	0.018
SH3GL2	SH3-domain GRB2-like 2	0.018
NCOA1	nuclear receptor coactivator 1	0.018
CD247	CD247 molecule	0.018
ARRB1	arrestin, beta 1	0.017
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.017
ADAM9	ADAM metallopeptidase domain 9	0.017
VCL	vinculin	0.017
RPA1	replication protein A1, 70kDa	0.017
MYL12B	myosin, light chain 12B, regulatory	0.017
PRPF38A	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A	0.016
NCF1	neutrophil cytosolic factor 1	0.016
OCRL	oculocerebrorenal syndrome of Lowe	0.016
CTTN	cortactin	0.015
CFH	complement factor H	0.015
RIN1	Ras and Rab interactor 1	0.015
MCM6	minichromosome maintenance complex component 6	0.015
SORBS3	sorbin and SH3 domain containing 3	0.015
CORO1C	coronin, actin binding protein, 1C	0.015
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.015
RAB14	RAB14, member RAS oncogene family	0.015
ENG	endoglin	0.014
NCOA6	nuclear receptor coactivator 6	0.014
SNX2	sorting nexin 2	0.014	Worm
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.014
DUSP23	dual specificity phosphatase 23	0.014
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.014
ITSN1	intersectin 1 (SH3 domain protein)	0.014
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.013
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.013
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.013
ZCCHC17	zinc finger, CCHC domain containing 17	0.013
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.013
C12orf44	chromosome 12 open reading frame 44	0.013
PTPRC	protein tyrosine phosphatase, receptor type, C	0.013
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.012
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.012
DNM1	dynamin 1	0.012
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.012
UFD1L	ubiquitin fusion degradation 1 like (yeast)	0.012
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.012	Worm
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.012
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.012
AMBRA1	autophagy/beclin-1 regulator 1	0.011
GOLGA2	golgin A2	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011	Worm
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.011
ANXA4	annexin A4	0.011	Worm
THBS1	thrombospondin 1	0.011
FGF2	fibroblast growth factor 2 (basic)	0.011
RB1	retinoblastoma 1	0.011
VCAM1	vascular cell adhesion molecule 1	0.010
SQSTM1	sequestosome 1	0.010
WASF1	WAS protein family, member 1	0.010