IMP

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Homo sapiens

3 genes annotated in human

negative regulation of platelet aggregation

Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of platelet aggregation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of platelet aggregation" (in gray)

Name	Description	Probability	Func Analog Organism
C1QA	complement component 1, q subcomponent, A chain	1.000	Human
C1QC	complement component 1, q subcomponent, C chain	0.999	Human
C1QB	complement component 1, q subcomponent, B chain	0.995	Human
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.741
SYK	spleen tyrosine kinase	0.695
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.665
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.577
NCF1	neutrophil cytosolic factor 1	0.489
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.486
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.278
CDCP1	CUB domain containing protein 1	0.239
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.236
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.234
MARCO	macrophage receptor with collagenous structure	0.218
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.179
ACTB	actin, beta	0.148
TRIM9	tripartite motif containing 9	0.137
CYBA	cytochrome b-245, alpha polypeptide	0.134
BLNK	B-cell linker	0.130
CSK	c-src tyrosine kinase	0.103
STAB1	stabilin 1	0.095
PRKCA	protein kinase C, alpha	0.094
NCF4	neutrophil cytosolic factor 4, 40kDa	0.093
ARRDC3	arrestin domain containing 3	0.088
VSIG4	V-set and immunoglobulin domain containing 4	0.087
KRT5	keratin 5	0.086
C1R	complement component 1, r subcomponent	0.085
SLAMF8	SLAM family member 8	0.080
PRKCB	protein kinase C, beta	0.075
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.072
DCN	decorin	0.069
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.067
MRVI1	murine retrovirus integration site 1 homolog	0.066
PTEN	phosphatase and tensin homolog	0.062
MYH9	myosin, heavy chain 9, non-muscle	0.056
TREM2	triggering receptor expressed on myeloid cells 2	0.056
TBC1D10A	TBC1 domain family, member 10A	0.056
MSR1	macrophage scavenger receptor 1	0.055
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.050
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.048
CD68	CD68 molecule	0.046
TYROBP	TYRO protein tyrosine kinase binding protein	0.045
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.045
IL32	interleukin 32	0.043
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.042
COMP	cartilage oligomeric matrix protein	0.042
MPEG1	macrophage expressed 1	0.041
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.040	Human
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.040
GAB2	GRB2-associated binding protein 2	0.039
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.037
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.037
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.036
AVPR2	arginine vasopressin receptor 2	0.036
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.035
TLR7	toll-like receptor 7	0.034
DDR2	discoidin domain receptor tyrosine kinase 2	0.033
APOE	apolipoprotein E	0.032
CD163	CD163 molecule	0.032
NCF2	neutrophil cytosolic factor 2	0.031
CSF1R	colony stimulating factor 1 receptor	0.031
TMEM176B	transmembrane protein 176B	0.031
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.031
CDKL5	cyclin-dependent kinase-like 5	0.030
ACP5	acid phosphatase 5, tartrate resistant	0.030
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.030
IGSF6	immunoglobulin superfamily, member 6	0.029
C4B	complement component 4B (Chido blood group)	0.029
MYO1D	myosin ID	0.028
APOC1	apolipoprotein C-I	0.028
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.028
SLC15A3	solute carrier family 15, member 3	0.027
GGT5	gamma-glutamyltransferase 5	0.027
MMP19	matrix metallopeptidase 19	0.027
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.026
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.026
ADAP2	ArfGAP with dual PH domains 2	0.025
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.025
CMKLR1	chemokine-like receptor 1	0.024
A2M	alpha-2-macroglobulin	0.024
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.024
COL13A1	collagen, type XIII, alpha 1	0.024
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.024
EZR	ezrin	0.023
OLFML2B	olfactomedin-like 2B	0.023
MSN	moesin	0.023
CDH5	cadherin 5, type 2 (vascular endothelium)	0.023
PTPRA	protein tyrosine phosphatase, receptor type, A	0.021
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.021
FPR3	formyl peptide receptor 3	0.021
ZNF431	zinc finger protein 431	0.020
EMILIN1	elastin microfibril interfacer 1	0.020
C2	complement component 2	0.020
MUC1	mucin 1, cell surface associated	0.020
P2RY1	purinergic receptor P2Y, G-protein coupled, 1	0.020
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.020
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.019
TMSB4X	thymosin beta 4, X-linked	0.019
CD248	CD248 molecule, endosialin	0.019
WISP1	WNT1 inducible signaling pathway protein 1	0.019
COL6A1	collagen, type VI, alpha 1	0.019
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.019
HCST	hematopoietic cell signal transducer	0.019
NGFR	nerve growth factor receptor	0.018
TMEM176A	transmembrane protein 176A	0.018
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.018
COL8A2	collagen, type VIII, alpha 2	0.018
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.018
ADORA3	adenosine A3 receptor	0.018
EXT2	exostosin 2	0.018
SOX18	SRY (sex determining region Y)-box 18	0.017
CCL13	chemokine (C-C motif) ligand 13	0.017
SLC25A47	solute carrier family 25, member 47	0.017
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.017
LMNA	lamin A/C	0.017
CHRD	chordin	0.017
ELN	elastin	0.017
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	0.017	Human
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.017
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.017
SRCIN1	SRC kinase signaling inhibitor 1	0.017
COL14A1	collagen, type XIV, alpha 1	0.017
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.016
DOCK7	dedicator of cytokinesis 7	0.016
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.016
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.016
BAI1	brain-specific angiogenesis inhibitor 1	0.016
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.016
A1BG	alpha-1-B glycoprotein	0.016
LRP1	low density lipoprotein receptor-related protein 1	0.016
PRRX2	paired related homeobox 2	0.016
CRIP2	cysteine-rich protein 2	0.016
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.016
SEMA5B	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.016
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.016
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.016
STAC	SH3 and cysteine rich domain	0.016
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.016
F13A1	coagulation factor XIII, A1 polypeptide	0.016
FOLR2	folate receptor 2 (fetal)	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.015
PLTP	phospholipid transfer protein	0.015
PLIN4	perilipin 4	0.015
PLEKHO2	pleckstrin homology domain containing, family O member 2	0.015
NNMT	nicotinamide N-methyltransferase	0.015
APLP1	amyloid beta (A4) precursor-like protein 1	0.015
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.015
TCERG1L	transcription elongation regulator 1-like	0.015
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.015
HOXD8	homeobox D8	0.014
NKD2	naked cuticle homolog 2 (Drosophila)	0.014
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.014
ANGPTL2	angiopoietin-like 2	0.014
USP33	ubiquitin specific peptidase 33	0.014
AMN	amnionless homolog (mouse)	0.014
C3AR1	complement component 3a receptor 1	0.014
C1S	complement component 1, s subcomponent	0.014
COL3A1	collagen, type III, alpha 1	0.014
AKAP12	A kinase (PRKA) anchor protein 12	0.013
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.013
GDF9	growth differentiation factor 9	0.013
CXCL9	chemokine (C-X-C motif) ligand 9	0.013
CTSZ	cathepsin Z	0.013
EGFR	epidermal growth factor receptor	0.013
SCARF2	scavenger receptor class F, member 2	0.013
MRC1	mannose receptor, C type 1	0.013
VAV1	vav 1 guanine nucleotide exchange factor	0.013
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.013
GPR124	G protein-coupled receptor 124	0.013
KIRREL	kin of IRRE like (Drosophila)	0.013
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.013
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.013
SYNPO	synaptopodin	0.013
C10orf72	chromosome 10 open reading frame 72	0.013
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.013
SPRR2A	small proline-rich protein 2A	0.013
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.013
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.013
CD14	CD14 molecule	0.013
COL4A5	collagen, type IV, alpha 5	0.013
COL4A2	collagen, type IV, alpha 2	0.013
COL1A1	collagen, type I, alpha 1	0.013
HK3	hexokinase 3 (white cell)	0.013
THY1	Thy-1 cell surface antigen	0.012
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.012
CALB2	calbindin 2	0.012
TUBA1A	tubulin, alpha 1a	0.012
JPH3	junctophilin 3	0.012
ACVRL1	activin A receptor type II-like 1	0.012
GPX3	glutathione peroxidase 3 (plasma)	0.012
PHLDA3	pleckstrin homology-like domain, family A, member 3	0.012
CRLF1	cytokine receptor-like factor 1	0.012
GPR4	G protein-coupled receptor 4	0.012
SIX2	SIX homeobox 2	0.012
PTH1R	parathyroid hormone 1 receptor	0.012
COL5A3	collagen, type V, alpha 3	0.012
GLIS1	GLIS family zinc finger 1	0.012
PLIN1	perilipin 1	0.012
VWF	von Willebrand factor	0.012
TUBB3	tubulin, beta 3	0.012
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.012
FERMT3	fermitin family member 3	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
MXRA8	matrix-remodelling associated 8	0.012
FOXF2	forkhead box F2	0.012
HES2	hairy and enhancer of split 2 (Drosophila)	0.012
CNTNAP1	contactin associated protein 1	0.012
MARCH5	membrane-associated ring finger (C3HC4) 5	0.012
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.012
GPNMB	glycoprotein (transmembrane) nmb	0.012
PRND	prion protein 2 (dublet)	0.012
PDE4DIP	phosphodiesterase 4D interacting protein	0.012
ACAN	aggrecan	0.012
FBLN2	fibulin 2	0.012
IGSF21	immunoglobin superfamily, member 21	0.012
LEP	leptin	0.012
DOK5	docking protein 5	0.012
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.012
THBS2	thrombospondin 2	0.011
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.011
ITGA11	integrin, alpha 11	0.011
IFI27	interferon, alpha-inducible protein 27	0.011
MRGPRF	MAS-related GPR, member F	0.011
MMP25	matrix metallopeptidase 25	0.011
HIPK3	homeodomain interacting protein kinase 3	0.011
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.011
EBF2	early B-cell factor 2	0.011
CCL8	chemokine (C-C motif) ligand 8	0.011
FOXS1	forkhead box S1	0.011
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.011
CREB3L1	cAMP responsive element binding protein 3-like 1	0.011
WNT2	wingless-type MMTV integration site family member 2	0.011
TMEM119	transmembrane protein 119	0.011
KLF5	Kruppel-like factor 5 (intestinal)	0.011
HMGXB3	HMG box domain containing 3	0.011
GLI2	GLI family zinc finger 2	0.011
CD300C	CD300c molecule	0.011
EMILIN2	elastin microfibril interfacer 2	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.011
PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.011
KCNK13	potassium channel, subfamily K, member 13	0.011
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.011
ENG	endoglin	0.011
CCND2	cyclin D2	0.011
TCN2	transcobalamin II	0.011
DUSP23	dual specificity phosphatase 23	0.011
APOL4	apolipoprotein L, 4	0.011
CARHSP1	calcium regulated heat stable protein 1, 24kDa	0.011
RBMS3	RNA binding motif, single stranded interacting protein 3	0.011
COL1A2	collagen, type I, alpha 2	0.011
SEPT4	septin 4	0.011
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	0.011
DMRTA2	DMRT-like family A2	0.011
EGF	epidermal growth factor	0.011
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.011
LRRC15	leucine rich repeat containing 15	0.011
APOA1	apolipoprotein A-I	0.011
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.011
SPON2	spondin 2, extracellular matrix protein	0.011
HIC1	hypermethylated in cancer 1	0.011
NMT2	N-myristoyltransferase 2	0.011
SLC7A10	solute carrier family 7, (neutral amino acid transporter, y+ system) member 10	0.011
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.011
C3	complement component 3	0.010
ADRA1D	adrenergic, alpha-1D-, receptor	0.010
EPHB2	EPH receptor B2	0.010
NELL1	NEL-like 1 (chicken)	0.010
PHF17	PHD finger protein 17	0.010
WISP2	WNT1 inducible signaling pathway protein 2	0.010
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.010
PCDH17	protocadherin 17	0.010
CLDN5	claudin 5	0.010
BEAN1	brain expressed, associated with NEDD4, 1	0.010
FGF4	fibroblast growth factor 4	0.010
DGKA	diacylglycerol kinase, alpha 80kDa	0.010
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.010
ZFAND5	zinc finger, AN1-type domain 5	0.010
CRHR1	corticotropin releasing hormone receptor 1	0.010
WNT6	wingless-type MMTV integration site family, member 6	0.010
C1QTNF2	C1q and tumor necrosis factor related protein 2	0.010	Human
POLH	polymerase (DNA directed), eta	0.010
S100A3	S100 calcium binding protein A3	0.010
DLL4	delta-like 4 (Drosophila)	0.010
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	0.010
GJA4	gap junction protein, alpha 4, 37kDa	0.010
NGF	nerve growth factor (beta polypeptide)	0.010
KCNK9	potassium channel, subfamily K, member 9	0.010
TUBB2B	tubulin, beta 2B	0.010
LRRC8C	leucine rich repeat containing 8 family, member C	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
MFI2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	0.010
LGALS9	lectin, galactoside-binding, soluble, 9	0.010
PODN	podocan	0.010
MPP1	membrane protein, palmitoylated 1, 55kDa	0.010
AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.010
AJAP1	adherens junctions associated protein 1	0.010
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.010
RNASE1	ribonuclease, RNase A family, 1 (pancreatic)	0.010