IMP

Process View

Homo sapiens

1 genes annotated in human

isoquinoline alkaloid metabolic process

The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "isoquinoline alkaloid metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "isoquinoline alkaloid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	1.000
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.981
MAT1A	methionine adenosyltransferase I, alpha	0.512
ADH6	alcohol dehydrogenase 6 (class V)	0.429
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.317
ALDOB	aldolase B, fructose-bisphosphate	0.280
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.265
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.207
FETUB	fetuin B	0.200
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.188	Human
GLYAT	glycine-N-acyltransferase	0.181
MAST1	microtubule associated serine/threonine kinase 1	0.171
OTC	ornithine carbamoyltransferase	0.151
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.130
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.129
AADAC	arylacetamide deacetylase (esterase)	0.126
MUC3A	mucin 3A, cell surface associated	0.125
HRG	histidine-rich glycoprotein	0.120
FMO4	flavin containing monooxygenase 4	0.118
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.111
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.107	Human
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.107
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.106	Human
C8B	complement component 8, beta polypeptide	0.103
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.097
C6	complement component 6	0.097
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.094
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.075	Human
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.072	Human
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.072	Human
MTTP	microsomal triglyceride transfer protein	0.068
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.067
AGXT2	alanine--glyoxylate aminotransferase 2	0.066
CFHR4	complement factor H-related 4	0.064
C4BPA	complement component 4 binding protein, alpha	0.061
C8A	complement component 8, alpha polypeptide	0.058
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.057
XDH	xanthine dehydrogenase	0.054
DAO	D-amino-acid oxidase	0.053
TMPRSS6	transmembrane protease, serine 6	0.052
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.049
G6PC	glucose-6-phosphatase, catalytic subunit	0.047
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.047
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.047
GSTA3	glutathione S-transferase alpha 3	0.046
LRRC31	leucine rich repeat containing 31	0.045
A1CF	APOBEC1 complementation factor	0.043
F9	coagulation factor IX	0.041
ATP10B	ATPase, class V, type 10B	0.037
ANXA10	annexin A10	0.037
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.036
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.035
APOC3	apolipoprotein C-III	0.034
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.033
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.033
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.033
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.033
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.033
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.032
MEP1B	meprin A, beta	0.032
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.031
SAA4	serum amyloid A4, constitutive	0.031
A2M	alpha-2-macroglobulin	0.031
FGL1	fibrinogen-like 1	0.030
BHMT	betaine--homocysteine S-methyltransferase	0.030
RAB3D	RAB3D, member RAS oncogene family	0.027
PZP	pregnancy-zone protein	0.027
GYS2	glycogen synthase 2 (liver)	0.027
F13B	coagulation factor XIII, B polypeptide	0.027
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.026
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.025
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.025
TTPA	tocopherol (alpha) transfer protein	0.025
HABP2	hyaluronan binding protein 2	0.024
DNASE1L3	deoxyribonuclease I-like 3	0.024
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.024
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.024
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.024
KLK13	kallikrein-related peptidase 13	0.024
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.023
F11	coagulation factor XI	0.023
LECT2	leukocyte cell-derived chemotaxin 2	0.022
PON1	paraoxonase 1	0.022
PAH	phenylalanine hydroxylase	0.022
FEV	FEV (ETS oncogene family)	0.021
ACRV1	acrosomal vesicle protein 1	0.021
LPA	lipoprotein, Lp(a)	0.020
DIO1	deiodinase, iodothyronine, type I	0.020
CRP	C-reactive protein, pentraxin-related	0.020
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.019
DPYS	dihydropyrimidinase	0.019
HPX	hemopexin	0.019
PNLIPRP1	pancreatic lipase-related protein 1	0.018
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.018
PLA2G10	phospholipase A2, group X	0.018
CNGA1	cyclic nucleotide gated channel alpha 1	0.018
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.018
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.018
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.018
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.018
HNF4G	hepatocyte nuclear factor 4, gamma	0.018
SGK2	serum/glucocorticoid regulated kinase 2	0.018
CIDEB	cell death-inducing DFFA-like effector b	0.018
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.017
ZG16	zymogen granule protein 16 homolog (rat)	0.017
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.017
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.017
CCL16	chemokine (C-C motif) ligand 16	0.017
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.016
AQP8	aquaporin 8	0.016
AFM	afamin	0.016
FAM164C	family with sequence similarity 164, member C	0.016
C9	complement component 9	0.016
RFPL3	ret finger protein-like 3	0.016
HGD	homogentisate 1,2-dioxygenase	0.016
ADRA1A	adrenergic, alpha-1A-, receptor	0.016
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.016
ERN2	endoplasmic reticulum to nucleus signaling 2	0.015
PIPOX	pipecolic acid oxidase	0.015
APCS	amyloid P component, serum	0.015
MIA2	melanoma inhibitory activity 2	0.015
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.015
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.015
GNMT	glycine N-methyltransferase	0.015
NTS	neurotensin	0.015
HAL	histidine ammonia-lyase	0.015
TMC5	transmembrane channel-like 5	0.014
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.014
C4BPB	complement component 4 binding protein, beta	0.014
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.014
ZKSCAN3	zinc finger with KRAB and SCAN domains 3	0.014
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.014
APOC4	apolipoprotein C-IV	0.014
BCL2L10	BCL2-like 10 (apoptosis facilitator)	0.014
COLEC10	collectin sub-family member 10 (C-type lectin)	0.014
GJB1	gap junction protein, beta 1, 32kDa	0.014
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.014
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.014
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.013
TMPRSS2	transmembrane protease, serine 2	0.013
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.013
LHB	luteinizing hormone beta polypeptide	0.013
TUT1	terminal uridylyl transferase 1, U6 snRNA-specific	0.013
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.013
PAX9	paired box 9	0.013
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.013
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.013
CPB2	carboxypeptidase B2 (plasma)	0.013
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.013
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.013
CTRC	chymotrypsin C (caldecrin)	0.013
IFNA5	interferon, alpha 5	0.012
FABP1	fatty acid binding protein 1, liver	0.012
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.012
CES3	carboxylesterase 3	0.012
PTK6	PTK6 protein tyrosine kinase 6	0.012
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	0.012
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.012
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.012
KRT13	keratin 13	0.012
OR1D2	olfactory receptor, family 1, subfamily D, member 2	0.012
SLC19A3	solute carrier family 19, member 3	0.012
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.012	Human
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.012
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.012
UGT2A3	UDP glucuronosyltransferase 2 family, polypeptide A3	0.012
CAPN5	calpain 5	0.012
SLC30A10	solute carrier family 30, member 10	0.012
SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	0.012
FOXA1	forkhead box A1	0.011
APOE	apolipoprotein E	0.011
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.011
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.011
SPEF1	sperm flagellar 1	0.011
TEC	tec protein tyrosine kinase	0.011
MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	0.011
IFNA2	interferon, alpha 2	0.011
CLCA4	chloride channel accessory 4	0.011
LIPF	lipase, gastric	0.011
KRT4	keratin 4	0.011
ADAM20	ADAM metallopeptidase domain 20	0.011
TM4SF4	transmembrane 4 L six family member 4	0.011
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.011
HHLA2	HERV-H LTR-associating 2	0.011
MASP2	mannan-binding lectin serine peptidase 2	0.011
CPS1	carbamoyl-phosphate synthase 1, mitochondrial	0.011
SLC17A2	solute carrier family 17 (sodium phosphate), member 2	0.011
C9orf68	chromosome 9 open reading frame 68	0.011
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.011
HRASLS2	HRAS-like suppressor 2	0.011
ZBTB25	zinc finger and BTB domain containing 25	0.011
REG1A	regenerating islet-derived 1 alpha	0.011
LRRC19	leucine rich repeat containing 19	0.011
DEFB1	defensin, beta 1	0.011
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.011
SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.011
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.010
VIL1	villin 1	0.010
NDRG2	NDRG family member 2	0.010
MORN1	MORN repeat containing 1	0.010
FABP2	fatty acid binding protein 2, intestinal	0.010
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.010
SPRR1A	small proline-rich protein 1A	0.010
ZNF132	zinc finger protein 132	0.010
SLC38A4	solute carrier family 38, member 4	0.010
CD4	CD4 molecule	0.010
RDH16	retinol dehydrogenase 16 (all-trans)	0.010
CYB5A	cytochrome b5 type A (microsomal)	0.010
TAS2R16	taste receptor, type 2, member 16	0.010