IMP
Process View
negative regulation of alkaline phosphatase activity
Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of alkaline phosphatase activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.952 | ||
| PLXND1 | plexin D1 | 0.941 | ||
| ENG | endoglin | 0.898 | ||
| SORBS1 | sorbin and SH3 domain containing 1 | 0.408 | ||
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.337 | ||
| THBS1 | thrombospondin 1 | 0.327 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.215 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.176 | ||
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | 0.105 | ||
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.103 | Human | |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 0.102 | Human | |
| NRP1 | neuropilin 1 | 0.101 | ||
| SORBS2 | sorbin and SH3 domain containing 2 | 0.080 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.078 | ||
| TGFBR3 | transforming growth factor, beta receptor III | 0.068 | ||
| PLXNB2 | plexin B2 | 0.067 | ||
| SH3RF1 | SH3 domain containing ring finger 1 | 0.060 | ||
| APP | amyloid beta (A4) precursor protein | 0.046 | ||
| PLXNB1 | plexin B1 | 0.036 | ||
| ACVR2B | activin A receptor, type IIB | 0.030 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.028 | ||
| CD22 | CD22 molecule | 0.016 | ||
| NOVA1 | neuro-oncological ventral antigen 1 | 0.016 | ||
| TGFB2 | transforming growth factor, beta 2 | 0.015 | ||
| WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 | 0.013 | ||
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.013 | ||
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.013 | ||
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.013 | ||
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.011 | ||
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.011 | ||
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.011 | ||
| MMRN2 | multimerin 2 | 0.011 | ||
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.010 | ||
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.010 | ||
| BDNF | brain-derived neurotrophic factor | 0.010 |