IMP

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Homo sapiens

21 genes annotated in human

hypertrophic cardiomyopathy

DOID:11984

An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hypertrophic cardiomyopathy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hypertrophic cardiomyopathy" (in gray)

Name	Description	Probability	Func Analog Organism
TNNI1	troponin I type 1 (skeletal, slow)	1.000	Human
TNNC1	troponin C type 1 (slow)	1.000
TRIM63	tripartite motif containing 63	0.997
ESR2	estrogen receptor 2 (ER beta)	0.993
TCAP	titin-cap (telethonin)	0.993
TNNT2	troponin T type 2 (cardiac)	0.981
ACTN2	actinin, alpha 2	0.958
TPM2	tropomyosin 2 (beta)	0.933	Human
NEB	nebulin	0.930
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.923
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.919
TNNT1	troponin T type 1 (skeletal, slow)	0.914	Human
ACTA1	actin, alpha 1, skeletal muscle	0.903	Human
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.828
MYOZ1	myozenin 1	0.720	Human
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.657
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.530
TNNI3K	TNNI3 interacting kinase	0.371
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.332
ACTA2	actin, alpha 2, smooth muscle, aorta	0.326	Human
TNNI3	troponin I type 3 (cardiac)	0.324
TRIP6	thyroid hormone receptor interactor 6	0.311
ANK1	ankyrin 1, erythrocytic	0.275
CNN1	calponin 1, basic, smooth muscle	0.237
TNNI2	troponin I type 2 (skeletal, fast)	0.230	Human
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.205	Human
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.205
LDB3	LIM domain binding 3	0.174
MYOZ2	myozenin 2	0.148
CASQ1	calsequestrin 1 (fast-twitch, skeletal muscle)	0.134
MYPN	myopalladin	0.129
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.128
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.120
SVIL	supervillin	0.113
CAPN3	calpain 3, (p94)	0.103
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.098
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.097
CAV3	caveolin 3	0.095
CKM	creatine kinase, muscle	0.090
USP6	ubiquitin specific peptidase 6 (Tre-2 oncogene)	0.078
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.078
OBSL1	obscurin-like 1	0.077
SMPX	small muscle protein, X-linked	0.070
MYBPC3	myosin binding protein C, cardiac	0.067
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.062	Human
MYOD1	myogenic differentiation 1	0.059
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.052	Human
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.051
NRAP	nebulin-related anchoring protein	0.049	Human
ACTC1	actin, alpha, cardiac muscle 1	0.048
HOXA9	homeobox A9	0.047
MRPL41	mitochondrial ribosomal protein L41	0.046
XIRP1	xin actin-binding repeat containing 1	0.045
CASQ2	calsequestrin 2 (cardiac muscle)	0.044
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.043	Human
HSPB3	heat shock 27kDa protein 3	0.042
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.042	Human
CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.038
SMTNL1	smoothelin-like 1	0.037
PXN	paxillin	0.036
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.032
TPM1	tropomyosin 1 (alpha)	0.030
ITGB1BP3	integrin beta 1 binding protein 3	0.030
MYF6	myogenic factor 6 (herculin)	0.030
PYGM	phosphorylase, glycogen, muscle	0.029
FBP2	fructose-1,6-bisphosphatase 2	0.027
FHL2	four and a half LIM domains 2	0.026
PKD2L1	polycystic kidney disease 2-like 1	0.025
MYH11	myosin, heavy chain 11, smooth muscle	0.025
RAPSN	receptor-associated protein of the synapse	0.024
MYBPH	myosin binding protein H	0.023
TTN	titin	0.023
MYF5	myogenic factor 5	0.023
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.022
MYBPC1	myosin binding protein C, slow type	0.022
FHL3	four and a half LIM domains 3	0.021
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.021
MYLK2	myosin light chain kinase 2	0.019
HOXA1	homeobox A1	0.019
FERMT2	fermitin family member 2	0.019
MYOM2	myomesin (M-protein) 2, 165kDa	0.019
MYBPC2	myosin binding protein C, fast type	0.018
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.018
MYOT	myotilin	0.018
MEF2C	myocyte enhancer factor 2C	0.017
DES	desmin	0.017
KBTBD10	kelch repeat and BTB (POZ) domain containing 10	0.017
CLTC	clathrin, heavy chain (Hc)	0.016
MYOG	myogenin (myogenic factor 4)	0.016
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.016	Human
NPPB	natriuretic peptide B	0.016
FLNC	filamin C, gamma	0.015
ALPK3	alpha-kinase 3	0.015
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.015	Human
HRC	histidine rich calcium binding protein	0.015
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.015
TRIM55	tripartite motif containing 55	0.015
MB	myoglobin	0.014
LMOD2	leiomodin 2 (cardiac)	0.014
XIRP2	xin actin-binding repeat containing 2	0.014
CALD1	caldesmon 1	0.014
RPL3L	ribosomal protein L3-like	0.013
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.013
C10orf71	chromosome 10 open reading frame 71	0.013
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.013
GJA5	gap junction protein, alpha 5, 40kDa	0.013
CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	0.013
SRPK3	SRSF protein kinase 3	0.013
KRT36	keratin 36	0.013
MTA2	metastasis associated 1 family, member 2	0.012
MYOM1	myomesin 1, 185kDa	0.012
MUSTN1	musculoskeletal, embryonic nuclear protein 1	0.012
FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	0.012
ACTN3	actinin, alpha 3	0.011
TRIM54	tripartite motif containing 54	0.011
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	0.011
SPTB	spectrin, beta, erythrocytic	0.011
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.011
MYL9	myosin, light chain 9, regulatory	0.011	Human
SRL	sarcalumenin	0.011
AQP7	aquaporin 7	0.011
SYNPO2	synaptopodin 2	0.011
DCAF6	DDB1 and CUL4 associated factor 6	0.011
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.010
SYNPO2L	synaptopodin 2-like	0.010
CHRNG	cholinergic receptor, nicotinic, gamma	0.010
HBZ	hemoglobin, zeta	0.010
KBTBD5	kelch repeat and BTB (POZ) domain containing 5	0.010
NEXN	nexilin (F actin binding protein)	0.008
PLN	phospholamban	0.006
JPH2	junctophilin 2	0.004
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.004
VCL	vinculin	0.002
CALR3	calreticulin 3	0.001