IMP

Process View

Homo sapiens

4 genes annotated in human

cardiac muscle adaptation

The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac muscle adaptation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac muscle adaptation" (in gray)

Name	Description	Probability	Func Analog Organism
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.903
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.821
TTN	titin	0.752
TRIM63	tripartite motif containing 63	0.690
MEF2A	myocyte enhancer factor 2A	0.674
HIST1H3B	histone cluster 1, H3b	0.491
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.446
HDAC9	histone deacetylase 9	0.403
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.387
CALCA	calcitonin-related polypeptide alpha	0.348
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.302
MYOZ1	myozenin 1	0.289
TBX5	T-box 5	0.239
HIST1H4F	histone cluster 1, H4f	0.227
DLG2	discs, large homolog 2 (Drosophila)	0.194
KLF13	Kruppel-like factor 13	0.174
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.135	Human
NEB	nebulin	0.097
ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	0.091
MYLK2	myosin light chain kinase 2	0.080
TRPC5	transient receptor potential cation channel, subfamily C, member 5	0.079	Human
MYOZ2	myozenin 2	0.074
MBNL1	muscleblind-like (Drosophila)	0.068
IRF2	interferon regulatory factor 2	0.059
TCF4	transcription factor 4	0.058
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.042
TRPC7	transient receptor potential cation channel, subfamily C, member 7	0.040	Human
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	0.035
PTPRA	protein tyrosine phosphatase, receptor type, A	0.034
C16orf74	chromosome 16 open reading frame 74	0.034
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.033
ARNT	aryl hydrocarbon receptor nuclear translocator	0.032
HDAC4	histone deacetylase 4	0.032
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.032
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.031	Human
OSBPL8	oxysterol binding protein-like 8	0.030
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.028
SPTBN1	spectrin, beta, non-erythrocytic 1	0.027
CAPN3	calpain 3, (p94)	0.026
PDPK1	3-phosphoinositide dependent protein kinase-1	0.025
CELF2	CUGBP, Elav-like family member 2	0.025
HAND2	heart and neural crest derivatives expressed 2	0.024
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.024
HDAC5	histone deacetylase 5	0.022
STMN4	stathmin-like 4	0.022
PJA2	praja ring finger 2	0.022
ADAM17	ADAM metallopeptidase domain 17	0.021
TCF21	transcription factor 21	0.019
STIM1	stromal interaction molecule 1	0.017
LRP12	low density lipoprotein receptor-related protein 12	0.017
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.017
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.016
NAP1L3	nucleosome assembly protein 1-like 3	0.016
AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	0.015
ZFPM2	zinc finger protein, multitype 2	0.015
PFN2	profilin 2	0.015
NXPH1	neurexophilin 1	0.015
REPS2	RALBP1 associated Eps domain containing 2	0.014
GAB2	GRB2-associated binding protein 2	0.014
GATA5	GATA binding protein 5	0.014
EPAS1	endothelial PAS domain protein 1	0.014
TMX4	thioredoxin-related transmembrane protein 4	0.013
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.013
STXBP5	syntaxin binding protein 5 (tomosyn)	0.013
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.013
KLHL2	kelch-like 2, Mayven (Drosophila)	0.013
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.012
ZNF532	zinc finger protein 532	0.012
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.012
MYT1L	myelin transcription factor 1-like	0.012
OBSL1	obscurin-like 1	0.012
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.012	Human
ENO3	enolase 3 (beta, muscle)	0.012
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.012
GAK	cyclin G associated kinase	0.012
TFG	TRK-fused gene	0.012
TRPM1	transient receptor potential cation channel, subfamily M, member 1	0.012
ANK2	ankyrin 2, neuronal	0.012
HPCAL4	hippocalcin like 4	0.011
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.011
TNNI2	troponin I type 2 (skeletal, fast)	0.011
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.011
ALX4	ALX homeobox 4	0.011
MCF2	MCF.2 cell line derived transforming sequence	0.011
VAV3	vav 3 guanine nucleotide exchange factor	0.011
WIPF2	WAS/WASL interacting protein family, member 2	0.011
ZEB2	zinc finger E-box binding homeobox 2	0.011
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.011
AP2A2	adaptor-related protein complex 2, alpha 2 subunit	0.010
PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	0.010
LRRC49	leucine rich repeat containing 49	0.010
DGKG	diacylglycerol kinase, gamma 90kDa	0.010