IMP

Process View

Homo sapiens

3 genes annotated in human

dosage compensation

Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dosage compensation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dosage compensation" (in gray)

Name	Description	Probability	Func Analog Organism
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.729	Worm
EXOSC3	exosome component 3	0.422
QKI	quaking homolog, KH domain RNA binding (mouse)	0.313
DICER1	dicer 1, ribonuclease type III	0.210
SUFU	suppressor of fused homolog (Drosophila)	0.194
SMC4	structural maintenance of chromosomes 4	0.143	Worm
ATXN1	ataxin 1	0.141
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.113
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.088	Worm
RHOXF2	Rhox homeobox family, member 2	0.086
NUMBL	numb homolog (Drosophila)-like	0.077
DIS3	DIS3 mitotic control homolog (S. cerevisiae)	0.074
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.070
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.068
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.061
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.059
RBPMS	RNA binding protein with multiple splicing	0.059
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.050
SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	0.048
ATN1	atrophin 1	0.045
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.044
RAD21	RAD21 homolog (S. pombe)	0.043
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.041
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.040
RBBP5	retinoblastoma binding protein 5	0.037
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.036
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.036
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.034
NCAPD2	non-SMC condensin I complex, subunit D2	0.034
PTBP2	polypyrimidine tract binding protein 2	0.033
LNX2	ligand of numb-protein X 2	0.030
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.029
DCP2	DCP2 decapping enzyme homolog (S. cerevisiae)	0.027
ATM	ataxia telangiectasia mutated	0.026
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.024
ZFP28	zinc finger protein 28 homolog (mouse)	0.023
EED	embryonic ectoderm development	0.022
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.021
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.020
NCAPH2	non-SMC condensin II complex, subunit H2	0.020
MSL1	male-specific lethal 1 homolog (Drosophila)	0.019	Fly
LDB1	LIM domain binding 1	0.018
GLI1	GLI family zinc finger 1	0.018
PEX26	peroxisomal biogenesis factor 26	0.018
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.018
PRUNE2	prune homolog 2 (Drosophila)	0.017
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.017
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.017
RNF114	ring finger protein 114	0.016
SMC2	structural maintenance of chromosomes 2	0.016	Worm
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.016
ZNF331	zinc finger protein 331	0.015
LDB2	LIM domain binding 2	0.015
RGS3	regulator of G-protein signaling 3	0.015
LENG8	leukocyte receptor cluster (LRC) member 8	0.014
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.014
TARDBP	TAR DNA binding protein	0.014
PSIP1	PC4 and SFRS1 interacting protein 1	0.014
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.013
SMEK1	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	0.013
CELF3	CUGBP, Elav-like family member 3	0.013
MSL3	male-specific lethal 3 homolog (Drosophila)	0.013	Fly
RNF5	ring finger protein 5	0.013
TRIM39	tripartite motif containing 39	0.013
GLIS2	GLIS family zinc finger 2	0.013
SP3	Sp3 transcription factor	0.013
NXF1	nuclear RNA export factor 1	0.013
DZIP3	DAZ interacting protein 3, zinc finger	0.012
QPRT	quinolinate phosphoribosyltransferase	0.012
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.012
SS18	synovial sarcoma translocation, chromosome 18	0.012
KDM3B	lysine (K)-specific demethylase 3B	0.012
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.012
MSL2	male-specific lethal 2 homolog (Drosophila)	0.012	Fly
GTF2I	general transcription factor IIi	0.012
DUSP23	dual specificity phosphatase 23	0.012
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.011
RBM14	RNA binding motif protein 14	0.011
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.011
CHFR	checkpoint with forkhead and ring finger domains	0.011
EXOSC2	exosome component 2	0.011
NCAPD3	non-SMC condensin II complex, subunit D3	0.011
NFYA	nuclear transcription factor Y, alpha	0.011
PCBP1	poly(rC) binding protein 1	0.011
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.011
FCHSD2	FCH and double SH3 domains 2	0.010
HIPK1	homeodomain interacting protein kinase 1	0.010
C17orf28	chromosome 17 open reading frame 28	0.010
EXOSC1	exosome component 1	0.010
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.010
DMRTB1	DMRT-like family B with proline-rich C-terminal, 1	0.010
RBM24	RNA binding motif protein 24	0.010
XRN2	5'-3' exoribonuclease 2	0.010
PHTF2	putative homeodomain transcription factor 2	0.010
PIAS2	protein inhibitor of activated STAT, 2	0.010