IMP
Process View
granzyme mediated apoptotic signaling pathway
A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
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Click on a gene's description to view its network relationships with genes known to be involved in "granzyme mediated apoptotic signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.946 | Human | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.808 | ||
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.549 | ||
| CTSA | cathepsin A | 0.413 | ||
| ITM2B | integral membrane protein 2B | 0.113 | ||
| GBA | glucosidase, beta, acid | 0.089 | ||
| GNS | glucosamine (N-acetyl)-6-sulfatase | 0.060 | ||
| YPEL5 | yippee-like 5 (Drosophila) | 0.034 | ||
| TMEM11 | transmembrane protein 11 | 0.030 | ||
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.030 | ||
| NCSTN | nicastrin | 0.027 | ||
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.026 | ||
| RNF13 | ring finger protein 13 | 0.022 | ||
| HEXB | hexosaminidase B (beta polypeptide) | 0.020 | ||
| LEPROT | leptin receptor overlapping transcript | 0.020 | ||
| OPA1 | optic atrophy 1 (autosomal dominant) | 0.019 | ||
| VCAN | versican | 0.018 | ||
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | 0.014 | ||
| MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha | 0.013 | ||
| SDCBP | syndecan binding protein (syntenin) | 0.012 | ||
| BCL2 | B-cell CLL/lymphoma 2 | 0.011 | ||
| PRF1 | perforin 1 (pore forming protein) | 0.011 |