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Homo sapiens

4 genes annotated in human

adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
GRIP1	glutamate receptor interacting protein 1	1.000
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.991	Human
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.987	Human
GRIA4	glutamate receptor, ionotrophic, AMPA 4	0.940	Human
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.936
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.733
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	0.634
PICK1	protein interacting with PRKCA 1	0.474
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.379
NEUROD1	neurogenic differentiation 1	0.341
NRXN1	neurexin 1	0.275
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.250
GRM7	glutamate receptor, metabotropic 7	0.247
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	0.208
GAP43	growth associated protein 43	0.195
CA10	carbonic anhydrase X	0.174
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.171
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.171
GPR6	G protein-coupled receptor 6	0.161
ACTL6B	actin-like 6B	0.160
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.151
RALYL	RALY RNA binding protein-like	0.131
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.130
PRKCG	protein kinase C, gamma	0.125
MYT1	myelin transcription factor 1	0.122
DPP6	dipeptidyl-peptidase 6	0.120
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.115
GRIA3	glutamate receptor, ionotrophic, AMPA 3	0.115	Human
GRIK2	glutamate receptor, ionotropic, kainate 2	0.103	Human
NTNG1	netrin G1	0.102
KIAA1045	KIAA1045	0.098
PRLHR	prolactin releasing hormone receptor	0.094
RGS7	regulator of G-protein signaling 7	0.093
KCNB1	potassium voltage-gated channel, Shab-related subfamily, member 1	0.093
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	0.091
SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)	0.089
GRIK1	glutamate receptor, ionotropic, kainate 1	0.086
SEZ6L	seizure related 6 homolog (mouse)-like	0.077
RIT2	Ras-like without CAAX 2	0.076
AFF2	AF4/FMR2 family, member 2	0.075
JPH3	junctophilin 3	0.069
CDH12	cadherin 12, type 2 (N-cadherin 2)	0.065
SYN2	synapsin II	0.064
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.062
TTPA	tocopherol (alpha) transfer protein	0.059
HMP19	HMP19 protein	0.058
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.056
RIMS1	regulating synaptic membrane exocytosis 1	0.056
NELL1	NEL-like 1 (chicken)	0.056
GRM3	glutamate receptor, metabotropic 3	0.055	Human Rat Fly
KCNIP2	Kv channel interacting protein 2	0.055
GRIK5	glutamate receptor, ionotropic, kainate 5	0.054
SYT13	synaptotagmin XIII	0.053
CNTN6	contactin 6	0.050
SORCS3	sortilin-related VPS10 domain containing receptor 3	0.049
KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9	0.048
FGF12	fibroblast growth factor 12	0.048
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.046
LSAMP	limbic system-associated membrane protein	0.046
TRPC3	transient receptor potential cation channel, subfamily C, member 3	0.045
CTNNA2	catenin (cadherin-associated protein), alpha 2	0.045
GRID2	glutamate receptor, ionotropic, delta 2	0.045
KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	0.045
NOL4	nucleolar protein 4	0.044
CADPS	Ca++-dependent secretion activator	0.041
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.039
FABP7	fatty acid binding protein 7, brain	0.038
LPHN3	latrophilin 3	0.037
STMN4	stathmin-like 4	0.037
HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	0.037
KIAA0319	KIAA0319	0.037
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.036
PCDH8	protocadherin 8	0.036
PCDHAC1	protocadherin alpha subfamily C, 1	0.034
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.033
FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	0.033
ZMAT4	zinc finger, matrin-type 4	0.032
CRB1	crumbs homolog 1 (Drosophila)	0.032
GNG4	guanine nucleotide binding protein (G protein), gamma 4	0.031
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.031
GRIK3	glutamate receptor, ionotropic, kainate 3	0.030
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	0.030
LRP1B	low density lipoprotein receptor-related protein 1B	0.030
GRM8	glutamate receptor, metabotropic 8	0.029
LRRTM4	leucine rich repeat transmembrane neuronal 4	0.028
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.028
APC2	adenomatosis polyposis coli 2	0.028
VSTM2A	V-set and transmembrane domain containing 2A	0.028
SIX6	SIX homeobox 6	0.028
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	0.027
DRD1	dopamine receptor D1	0.026
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	0.026
ASTN1	astrotactin 1	0.025
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.025
KCNK2	potassium channel, subfamily K, member 2	0.025
MGAT4C	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	0.024
ATP1B2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.024
OPRK1	opioid receptor, kappa 1	0.024
MYT1L	myelin transcription factor 1-like	0.024
SNAP25	synaptosomal-associated protein, 25kDa	0.024
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.024
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.023
CRH	corticotropin releasing hormone	0.023
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.023
RIMS2	regulating synaptic membrane exocytosis 2	0.023
ATP1B4	ATPase, Na+/K+ transporting, beta 4 polypeptide	0.023
DDX25	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25	0.023
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	0.023
ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.023
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.022
CNTN2	contactin 2 (axonal)	0.022
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.022
DCX	doublecortin	0.022
FOXG1	forkhead box G1	0.022
PRMT8	protein arginine methyltransferase 8	0.022
EPHA5	EPH receptor A5	0.021
CELF3	CUGBP, Elav-like family member 3	0.021
IL1RAPL1	interleukin 1 receptor accessory protein-like 1	0.021
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.021
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.021
NRXN3	neurexin 3	0.021
ATP8A2	ATPase, aminophospholipid transporter, class I, type 8A, member 2	0.021
ATP2B3	ATPase, Ca++ transporting, plasma membrane 3	0.021
SCN3B	sodium channel, voltage-gated, type III, beta	0.021
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	0.021
SYP	synaptophysin	0.020
FGF14	fibroblast growth factor 14	0.020
STXBP5L	syntaxin binding protein 5-like	0.020
PCSK2	proprotein convertase subtilisin/kexin type 2	0.020
PEX5L	peroxisomal biogenesis factor 5-like	0.020
ADARB2	adenosine deaminase, RNA-specific, B2	0.020
CADM2	cell adhesion molecule 2	0.020
SH3GL3	SH3-domain GRB2-like 3	0.020
KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	0.020
CDH10	cadherin 10, type 2 (T2-cadherin)	0.020
BAI3	brain-specific angiogenesis inhibitor 3	0.019
TAC1	tachykinin, precursor 1	0.019
AP3B2	adaptor-related protein complex 3, beta 2 subunit	0.019
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.019
FAIM2	Fas apoptotic inhibitory molecule 2	0.019
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.019
KLHL1	kelch-like 1 (Drosophila)	0.019
CRHR2	corticotropin releasing hormone receptor 2	0.019
FAM123A	family with sequence similarity 123A	0.019
LPPR1	lipid phosphate phosphatase-related protein type 1	0.019
FSTL4	follistatin-like 4	0.018
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.018
UNC13A	unc-13 homolog A (C. elegans)	0.018
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.018
SH3GL2	SH3-domain GRB2-like 2	0.018
DGKB	diacylglycerol kinase, beta 90kDa	0.018
SV2C	synaptic vesicle glycoprotein 2C	0.018
PTPRT	protein tyrosine phosphatase, receptor type, T	0.017
PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	0.017
PMP2	peripheral myelin protein 2	0.017
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	0.017
GDF10	growth differentiation factor 10	0.017
MAGEB3	melanoma antigen family B, 3	0.017
ZNF536	zinc finger protein 536	0.016
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.016
NXPH1	neurexophilin 1	0.016
FXYD7	FXYD domain containing ion transport regulator 7	0.016
TMEM130	transmembrane protein 130	0.016
GLRA3	glycine receptor, alpha 3	0.016
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.016
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.015
SCG3	secretogranin III	0.015
MTMR7	myotubularin related protein 7	0.015
CRP	C-reactive protein, pentraxin-related	0.015
DNAH9	dynein, axonemal, heavy chain 9	0.015
CALCB	calcitonin-related polypeptide beta	0.015
DGKI	diacylglycerol kinase, iota	0.015
PKNOX2	PBX/knotted 1 homeobox 2	0.015
CHGB	chromogranin B (secretogranin 1)	0.015
KCNK10	potassium channel, subfamily K, member 10	0.015
TMEM151B	transmembrane protein 151B	0.015
GFRA2	GDNF family receptor alpha 2	0.014
ABCC12	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	0.014
ST8SIA3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.014
KCNV1	potassium channel, subfamily V, member 1	0.014
MAG	myelin associated glycoprotein	0.014
LMO3	LIM domain only 3 (rhombotin-like 2)	0.014
FGF4	fibroblast growth factor 4	0.014
CADM3	cell adhesion molecule 3	0.014
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.014
NRSN1	neurensin 1	0.014
SLITRK3	SLIT and NTRK-like family, member 3	0.014
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.014
CCK	cholecystokinin	0.014
CAMK1G	calcium/calmodulin-dependent protein kinase IG	0.014
ZBBX	zinc finger, B-box domain containing	0.014
GPC5	glypican 5	0.014
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.013
ACCN2	amiloride-sensitive cation channel 2, neuronal	0.013
RIMBP2	RIMS binding protein 2	0.013
GRM1	glutamate receptor, metabotropic 1	0.013	Human
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.013
ZNF157	zinc finger protein 157	0.013
STMN2	stathmin-like 2	0.013
NCAN	neurocan	0.013
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.013
USH2A	Usher syndrome 2A (autosomal recessive, mild)	0.013
TAAR2	trace amine associated receptor 2	0.013
LUZP2	leucine zipper protein 2	0.013
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.013
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.013
NCAM2	neural cell adhesion molecule 2	0.012
KCNIP4	Kv channel interacting protein 4	0.012
B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.012
KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.012
NKX2-1	NK2 homeobox 1	0.012
FCRL4	Fc receptor-like 4	0.012
LRRC7	leucine rich repeat containing 7	0.012
C1orf114	chromosome 1 open reading frame 114	0.012
OTX2	orthodenticle homeobox 2	0.012
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.012
SLITRK1	SLIT and NTRK-like family, member 1	0.012
DLG2	discs, large homolog 2 (Drosophila)	0.012
TMEM196	transmembrane protein 196	0.012
NXPH2	neurexophilin 2	0.012
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.012
SNTG1	syntrophin, gamma 1	0.011
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.011
LGI1	leucine-rich, glioma inactivated 1	0.011
SSTR2	somatostatin receptor 2	0.011
TAGLN3	transgelin 3	0.011
KALRN	kalirin, RhoGEF kinase	0.011
KIAA0408	KIAA0408	0.011
NEUROD2	neurogenic differentiation 2	0.011
SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.011
PAH	phenylalanine hydroxylase	0.011
RELN	reelin	0.011
SEMG2	semenogelin II	0.011
SLC26A4	solute carrier family 26, member 4	0.011
AMPH	amphiphysin	0.011
MYO16	myosin XVI	0.011
EFR3B	EFR3 homolog B (S. cerevisiae)	0.011
CDR1	cerebellar degeneration-related protein 1, 34kDa	0.011
ANKRD34C	ankyrin repeat domain 34C	0.010
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.010
GPR85	G protein-coupled receptor 85	0.010
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.010
INA	internexin neuronal intermediate filament protein, alpha	0.010
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.010
NPAS3	neuronal PAS domain protein 3	0.010
IGLON5	IgLON family member 5	0.010
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.010
C15orf59	chromosome 15 open reading frame 59	0.010
EPHA7	EPH receptor A7	0.010
SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.010
TRPM3	transient receptor potential cation channel, subfamily M, member 3	0.010
MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.010
MCF2	MCF.2 cell line derived transforming sequence	0.010
C9orf4	chromosome 9 open reading frame 4	0.010
MYF5	myogenic factor 5	0.010