IMP

Process View

Mus musculus

17 genes annotated in mouse

sperm capacitation

A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sperm capacitation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sperm capacitation" (in gray)

Name	Description	Probability	Func Analog Organism
Slc4a4	solute carrier family 4 (anion exchanger), member 4	0.751
Thrb	thyroid hormone receptor beta	0.707
Akap4	A kinase (PRKA) anchor protein 4	0.559
LOC100503041	PDZ domain-containing protein 7-like	0.494
Clrn1	clarin 1	0.325
Ush1g	Usher syndrome 1G homolog (human)	0.311
Atp1a4	ATPase, Na+/K+ transporting, alpha 4 polypeptide	0.288
Pdx1	pancreatic and duodenal homeobox 1	0.215
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.187
Cdh23	cadherin 23 (otocadherin)	0.159
Catsper1	cation channel, sperm associated 1	0.121
Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	0.112
Espn	espin	0.082
Rhpn1	rhophilin, Rho GTPase binding protein 1	0.077
Ceacam16	carcinoembryonic antigen-related cell adhesion molecule 16	0.067
Tecta	tectorin alpha	0.062
Foxa2	forkhead box A2	0.059
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.057
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.057
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.055
Kit	kit oncogene	0.054
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.053
Slc9a3r1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.052
Cadps2	Ca2+-dependent activator protein for secretion 2	0.047
Myo6	myosin VI	0.039
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.035
Pax2	paired box gene 2	0.034
Vmn1r51	vomeronasal 1 receptor 51	0.031
Adrb1	adrenergic receptor, beta 1	0.030
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.029
Hoxa10	homeobox A10	0.027
Myt1	myelin transcription factor 1	0.026
Slc12a6	solute carrier family 12, member 6	0.026
Umod	uromodulin	0.025
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.025
Myo15	myosin XV	0.024
Wnt5a	wingless-related MMTV integration site 5A	0.023
Slc26a8	solute carrier family 26, member 8	0.022	Mouse
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.021
Dnahc5	dynein, axonemal, heavy chain 5	0.021
Nrtn	neurturin	0.019
Ccdc39	coiled-coil domain containing 39	0.019
Neurod1	neurogenic differentiation 1	0.019
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.019
S1pr2	sphingosine-1-phosphate receptor 2	0.019
Rhbdd3	rhomboid domain containing 3	0.019
G6pc	glucose-6-phosphatase, catalytic	0.019
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.019
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.019
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.019
Pitx2	paired-like homeodomain transcription factor 2	0.019
Ggnbp1	gametogenetin binding protein 1	0.018
Fgf3	fibroblast growth factor 3	0.018
Gpr98	G protein-coupled receptor 98	0.016
Akap3	A kinase (PRKA) anchor protein 3	0.016
Eno4	enolase 4	0.016
Tex19.2	testis expressed gene 19.2	0.016
Gjb2	gap junction protein, beta 2	0.015
Fbxo2	F-box protein 2	0.015
Chd7	chromodomain helicase DNA binding protein 7	0.015
Fscb	fibrous sheath CABYR binding protein	0.014
Il10	interleukin 10	0.014
Myo7a	myosin VIIA	0.014
Gjb6	gap junction protein, beta 6	0.013
Cyct	cytochrome c, testis	0.013
Vangl2	vang-like 2 (van gogh, Drosophila)	0.013
Pgap1	post-GPI attachment to proteins 1	0.013
Dnahc11	dynein, axonemal, heavy chain 11	0.013
Fgf12	fibroblast growth factor 12	0.012
Foxi1	forkhead box I1	0.012
Ybx2	Y box protein 2	0.012
Acy3	aspartoacylase (aminoacylase) 3	0.012
Cldn11	claudin 11	0.012
Slco6b1	solute carrier organic anion transporter family, member 6b1	0.012
Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	0.012
Bad	BCL2-associated agonist of cell death	0.012
Eif4ebp2	eukaryotic translation initiation factor 4E binding protein 2	0.011
Aes	amino-terminal enhancer of split	0.011
Klc2	kinesin light chain 2	0.011
Gdf11	growth differentiation factor 11	0.011
Eya1	eyes absent 1 homolog (Drosophila)	0.011
Gdf5	growth differentiation factor 5	0.011
Vil1	villin 1	0.011
Esr1	estrogen receptor 1 (alpha)	0.011
Pcdhb2	protocadherin beta 2	0.011
Vim	vimentin	0.011
St8sia5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.011
Ppara	peroxisome proliferator activated receptor alpha	0.011
Fbxo36	F-box protein 36	0.011
Serpina3a	serine (or cysteine) peptidase inhibitor, clade A, member 3A	0.011
Prickle4	prickle homolog 4 (Drosophila)	0.011
Ndp	Norrie disease (pseudoglioma) (human)	0.010
Kcnu1	potassium channel, subfamily U, member 1	0.010
Homer1	homer homolog 1 (Drosophila)	0.010
Src	Rous sarcoma oncogene	0.010
Reep6	receptor accessory protein 6	0.010
Pde1c	phosphodiesterase 1C	0.010
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.010
Coq4	coenzyme Q4 homolog (yeast)	0.010
Pcx	pyruvate carboxylase	0.010