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Process View

Rattus norvegicus

30 genes annotated in rat

negative regulation of peptide hormone secretion

Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of peptide hormone secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of peptide hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Abcc8	ATP-binding cassette, subfamily C (CFTR/MRP), member 8	0.155
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.070
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.068
Grk4	G protein-coupled receptor kinase 4	0.067
Phkg1	phosphorylase kinase, gamma 1	0.064
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.063
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.056
Sqle	squalene epoxidase	0.052
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.049
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.049
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.047
Lep	leptin	0.044
Iapp	islet amyloid polypeptide	0.044
Sox17	SRY (sex determining region Y)-box 17	0.043
Gsg1l	GSG1-like	0.041
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.039
Avp	arginine vasopressin	0.039
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.039
Camk2g	calcium/calmodulin-dependent protein kinase II gamma	0.036
Begain	brain-enriched guanylate kinase-associated	0.035
Dhrs7c	dehydrogenase/reductase (SDR family) member 7C	0.035
Rxrg	retinoid X receptor gamma	0.035
Notch3	Notch homolog 3 (Drosophila)	0.034
Apoa4	apolipoprotein A-IV	0.034
Sc4mol	sterol-C4-methyl oxidase-like	0.033
Hhip	Hedgehog-interacting protein	0.033
Unc5a	unc-5 homolog A (C. elegans)	0.032
Kcnk3	potassium channel, subfamily K, member 3	0.031
Sdc3	syndecan 3	0.031
Hrh2	histamine receptor H 2	0.030
Trhr2	thyrotropin releasing hormone receptor 2	0.030
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.030
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.029	Human
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.029
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.029
Asgr1	asialoglycoprotein receptor 1	0.029
Prlhr	prolactin releasing hormone receptor	0.028
Cort	cortistatin	0.027
Mef2d	myocyte enhancer factor 2D	0.027
Cmklr1	chemokine-like receptor 1	0.027
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.027
Grp	gastrin releasing peptide	0.027
Drd1a	dopamine receptor D1A	0.026
Ghr	growth hormone receptor	0.026
Hrh3	histamine receptor H3	0.026
Obp3	alpha-2u globulin PGCL4	0.026	Mouse
Il9	interleukin 9	0.026
Gnb3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.025
Crhbp	corticotropin releasing hormone binding protein	0.025
Lhb	luteinizing hormone beta	0.024
LOC100360919	Immunoglobulin lambda-like polypeptide 1-like	0.024
Gh1	growth hormone 1	0.024
Dmrta1	DMRT-like family A1	0.024
Pecam1	platelet/endothelial cell adhesion molecule 1	0.024
Rho	rhodopsin	0.024
Sebox	SEBOX homeobox	0.024
Glp1r	glucagon-like peptide 1 receptor	0.024	Rat
Foxd4	forkhead box D4	0.023
Dcc	deleted in colorectal carcinoma	0.023
Enpep	glutamyl aminopeptidase	0.023
Gpr1	G protein-coupled receptor 1	0.023
Mip	major intrinsic protein of lens fiber	0.023
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.023
Cyp51	cytochrome P450, family 51	0.023
Magoh	mago-nashi homolog, proliferation-associated (Drosophila)	0.023
Acrv1	acrosomal vesicle protein 1	0.022
Grin1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.022
Grm7	glutamate receptor, metabotropic 7	0.022
Fat2	FAT tumor suppressor homolog 2 (Drosophila)	0.022
LOC100360587	hypothetical protein LOC100360587	0.022
Rab3b	RAB3B, member RAS oncogene family	0.022
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.022
Gabrr1	gamma-aminobutyric acid (GABA) receptor, rho 1	0.021
Adra2c	adrenergic, alpha-2C-, receptor	0.021
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.021
Gpr6	G protein-coupled receptor 6	0.021
Grifin	galectin-related inter-fiber protein	0.020
Mep1a	meprin 1 alpha	0.020
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.020
Vgf	VGF nerve growth factor inducible	0.020
Prl2a1	Prolactin family 2, subfamily a, member 1	0.020
Ppyr1	pancreatic polypeptide receptor 1	0.020
Lifr	leukemia inhibitory factor receptor alpha	0.020
Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11	0.019
Krt31	keratin 31	0.019
Nrg2	neuregulin 2	0.019
Grb2	growth factor receptor bound protein 2	0.019
Cntfr	ciliary neurotrophic factor receptor	0.019
Acat3	acetyl-Coenzyme A acetyltransferase 3	0.019
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.018
Pfkfb4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	0.018
Thrsp	thyroid hormone responsive	0.018
Tpcr12	putative olfactory receptor	0.018
A2bp1	ataxin 2 binding protein 1	0.018
Neurod2	neurogenic differentiation 2	0.018
Grm5	glutamate receptor, metabotropic 5	0.017
Rhbdl1	rhomboid, veinlet-like 1 (Drosophila)	0.017
Epor	erythropoietin receptor	0.017
Slc8a3	solute carrier family 8 (sodium/calcium exchanger), member 3	0.017
Grm6	glutamate receptor, metabotropic 6	0.017
Col10a1	collagen, type X, alpha 1	0.017
Olr414	olfactory receptor 414	0.017
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.017
Olr1078	olfactory receptor 1078	0.017
Hipk3	homeodomain interacting protein kinase 3	0.017
Lipe	lipase, hormone sensitive	0.017
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.017
Cd80	Cd80 molecule	0.017
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.017
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.017
Prl8a2	prolactin family 8, subfamily a, member 2	0.016
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.016
Akr1c12	aldo-keto reductase family 1, member C12	0.016
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.016
Sec31a	SEC31 homolog A (S. cerevisiae)	0.016
Rnf165	ring finger protein 165	0.016
Plin	perilipin	0.016
Rgs9	regulator of G-protein signaling 9	0.016
Egr3	early growth response 3	0.016
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.016
RGD1565859	RGD1565859	0.016
Myoc	myocilin	0.016
Pkia	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	0.016
Mycbp2	MYC binding protein 2	0.016
Olr1696	olfactory receptor 1696	0.016
Gip	gastric inhibitory polypeptide	0.016
Acpp	acid phosphatase, prostate	0.016
Flt1	FMS-related tyrosine kinase 1	0.016
Idi1	isopentenyl-diphosphate delta isomerase 1	0.015
Utrn	utrophin	0.015
Mertk	c-mer proto-oncogene tyrosine kinase	0.015
G6pc	glucose-6-phosphatase, catalytic subunit	0.015
Synj1	synaptojanin 1	0.015
Ucn	urocortin	0.015	Rat
Mapk10	mitogen activated protein kinase 10	0.015
Pde4c	phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)	0.015
Usp25	ubiquitin specific peptidase 25	0.015
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.015
Atxn1	ataxin 1	0.015
Psp	parotid secretory protein	0.015
Fgf20	fibroblast growth factor 20	0.015
Aldh6a1	aldehyde dehydrogenase 6 family, member A1	0.015
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.015
Slc22a25	solute carrier family 22, member 25	0.015
Acaca	acetyl-coenzyme A carboxylase alpha	0.015
Hcrtr1	hypocretin (orexin) receptor 1	0.015
Alpk3	alpha-kinase 3	0.015
Prkcg	protein kinase C, gamma	0.015
Pou2f2	POU class 2 homeobox 2	0.015
Prph2	peripherin 2	0.015
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.014
Adcy5	adenylate cyclase 5	0.014
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.014
Hmgcs1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	0.014
Mag	myelin-associated glycoprotein	0.014
Cpne9	copine family member IX	0.014
Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.014
Pnma1	paraneoplastic antigen MA1	0.014
Btc	betacellulin	0.014
Mcam	melanoma cell adhesion molecule	0.014
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.014
Grm4	glutamate receptor, metabotropic 4	0.014
Adam1a	a disintegrin and metallopeptidase domain 1a	0.014
Hand1	heart and neural crest derivatives expressed 1	0.014
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.014
Sst	somatostatin	0.013
Pla2g5	phospholipase A2, group V	0.013
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.013
Cdh22	cadherin 22	0.013
Shank1	SH3 and multiple ankyrin repeat domains 1	0.013
Pax6	paired box 6	0.013
Olr1867	olfactory receptor 1867	0.013
Gper	G protein-coupled estrogen receptor 1	0.013
Sag	S-antigen; retina and pineal gland (arrestin)	0.013
Tmod2	tropomodulin 2	0.013
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.013
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.013
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.013
Gabbr1	gamma-aminobutyric acid (GABA) B receptor 1	0.013
Ghsr	growth hormone secretagogue receptor	0.013
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.013	Rat
Hadh	hydroxyacyl-Coenzyme A dehydrogenase	0.013
Coro1b	coronin, actin-binding protein, 1B	0.013
Barhl2	BarH-like homeobox 2	0.013
Neu3	sialidase 3 (membrane sialidase)	0.013
Ccbp2	chemokine binding protein 2	0.013
Znf532	zinc finger protein 532	0.013
Smcp	sperm mitochondria-associated cysteine-rich protein	0.013
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.013
Ar	androgen receptor	0.013
Gfra2	GDNF family receptor alpha 2	0.013
Grik3	glutamate receptor, ionotropic, kainate 3	0.013
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.013
Fam57b	family with sequence similarity 57, member B	0.013
Tmem45b	transmembrane protein 45b	0.012
Foxa1	forkhead box A1	0.012
Syt9	synaptotagmin IX	0.012
Chrna4	cholinergic receptor, nicotinic, alpha 4	0.012
Vom2r32	vomeronasal 2 receptor, 32	0.012
Cel	carboxyl ester lipase	0.012
Npffr2	neuropeptide FF receptor 2	0.012
Hdac7	histone deacetylase 7	0.012
Kcna6	potassium voltage gated channel, shaker related subfamily, member 6	0.012
Syn1	synapsin I	0.012
Syt8	synaptotagmin VIII	0.012
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.012
Il1rap	interleukin 1 receptor accessory protein	0.012
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.012
Kif27	kinesin family member 27	0.012
Cyct	cytochrome c, testis	0.012
Dmgdh	dimethylglycine dehydrogenase	0.012
Dlg4	discs, large homolog 4 (Drosophila)	0.012
Ptgfr	prostaglandin F receptor	0.012
Sult1e1	sulfotransferase family 1E, estrogen-preferring, member 1	0.012
F13a1	coagulation factor XIII, A1 polypeptide	0.011
Thrb	thyroid hormone receptor beta	0.011
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.011
Adrb1	adrenergic, beta-1-, receptor	0.011
Fasn	fatty acid synthase	0.011
Hoxa2	homeo box A2	0.011
Syn3	synapsin III	0.011
Acadsb	acyl-Coenzyme A dehydrogenase, short/branched chain	0.011
Catsper2	cation channel, sperm associated 2	0.011
Mrgprf	MAS-related GPR, member F	0.011
Fbxo10	F-box protein 10	0.011
Chchd1	coiled-coil-helix-coiled-coil-helix domain containing 1	0.011
Myo1a	myosin IA	0.011
Sfrs9	splicing factor, arginine/serine-rich 9	0.011
Foxd3	forkhead box D3	0.011
Slc4a3	solute carrier family 4 (anion exchanger), member 3	0.011
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.011
LOC100360403	ATP-binding cassette, sub-family C, member 9-like	0.011
Olr1654	olfactory receptor 1654	0.011
Mtmr7	myotubularin related protein 7	0.011
Freq	frequenin homolog (Drosophila)	0.011
Nrsn1	neurensin 1	0.011
Necab2	N-terminal EF-hand calcium binding protein 2	0.011
Phka1	phosphorylase kinase, alpha 1	0.011
Ins2	insulin 2	0.011
Adra1b	adrenergic, alpha-1B-, receptor	0.011
Cml3	camello-like 3	0.011
Rhobtb2	Rho-related BTB domain containing 2	0.011
Aqp8	aquaporin 8	0.011
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.011
Ghrl	ghrelin/obestatin prepropeptide	0.011
Oprk1	opioid receptor, kappa 1	0.011
Pvrl4	poliovirus receptor-related 4	0.011
Acot12	acyl-CoA thioesterase 12	0.011
Zic1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
RT1-Bb	RT1 class II, locus Bb	0.010
Foxe3	forkhead box E3	0.010
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.010	Rat
Cgm4	carcinoembryonic antigen gene family 4	0.010
RGD1562502	similar to RIKEN cDNA 2610029G23	0.010
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.010
Klk1c10l2	kallikrein 1-related peptidase c10-like 2	0.010
Tacr1	tachykinin receptor 1	0.010
St18	suppression of tumorigenicity 18	0.010
Adcyap1	adenylate cyclase activating polypeptide 1	0.010
Neurod1	neurogenic differentiation 1	0.010
Mc4r	melanocortin 4 receptor	0.010
Kcnip3	Kv channel interacting protein 3, calsenilin	0.010
Sfrs2	splicing factor, arginine/serine-rich 2	0.010
Rftn2	raftlin family member 2	0.010
Kif1c	kinesin family member 1C	0.010
Mc5r	melanocortin 5 receptor	0.010
Gmeb2	glucocorticoid modulatory element binding protein 2	0.010
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.010
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.010
Cntn3	contactin 3 (plasmacytoma associated)	0.010
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.010
Prm3	protamine 3	0.010