IMP
Process View
i kappab kinase nf kappab signaling
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "i kappab kinase nf kappab signaling"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Parp9 | poly (ADP-ribose) polymerase family, member 9 | 0.034 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.032 | Human | |
| Cdk4 | cyclin-dependent kinase 4 | 0.032 | ||
| Tpm3 | tropomyosin 3, gamma | 0.029 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.029 | ||
| Icam1 | intercellular adhesion molecule 1 | 0.025 | ||
| Ndst1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.023 | ||
| LOC100365106 | rCG32755-like | 0.023 | ||
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.023 | ||
| Il6 | interleukin 6 | 0.023 | ||
| Cd86 | CD86 molecule | 0.020 | ||
| Shisa5 | shisa homolog 5 (Xenopus laevis) | 0.020 | ||
| Irf1 | interferon regulatory factor 1 | 0.019 | ||
| Slfn2 | schlafen 2 | 0.019 | ||
| Rad23b | RAD23 homolog B (S. cerevisiae) | 0.019 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.018 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.018 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.017 | ||
| LOC100362108 | poly (ADP-ribose) polymerase family, member 10 | 0.017 | ||
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.016 | ||
| Pla2g4a | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.016 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.016 | ||
| LOC686326 | similar to Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor-2) | 0.015 | ||
| Apol3 | apolipoprotein L, 3 | 0.015 | ||
| Parp14 | poly (ADP-ribose) polymerase family, member 14 | 0.015 | ||
| Il1b | interleukin 1 beta | 0.015 | ||
| LOC100363783 | rCG53773-like | 0.015 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.015 | Human | |
| Syngr2 | synaptogyrin 2 | 0.014 | ||
| Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 0.014 | ||
| Hist1h1a | histone cluster 1, H1a | 0.014 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.014 | ||
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.014 | ||
| Timp1 | TIMP metallopeptidase inhibitor 1 | 0.013 | ||
| Usf2 | upstream transcription factor 2, c-fos interacting | 0.013 | ||
| Tnks2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.013 | ||
| Mca32 | mast cell antigen 32 | 0.012 | ||
| Gbp2 | guanylate binding protein 2 | 0.012 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.012 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.012 | ||
| Il1a | interleukin 1 alpha | 0.012 | ||
| Sgta | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.012 | ||
| Vdac1 | voltage-dependent anion channel 1 | 0.012 | ||
| Svs3a | seminal vesicle secretory protein 3A | 0.012 | ||
| Papd5 | PAP associated domain containing 5 | 0.011 | ||
| Cap1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.011 | ||
| Zyx | zyxin | 0.011 | ||
| Dtx3l | deltex 3-like (Drosophila) | 0.011 | ||
| Il2rg | interleukin 2 receptor, gamma | 0.011 | ||
| Notch1 | Notch homolog 1, translocation-associated (Drosophila) | 0.011 | Fly | |
| Myh9 | myosin, heavy chain 9, non-muscle | 0.011 | ||
| Traf6 | Tnf receptor-associated factor 6 | 0.010 | Human Mouse | |
| Tmed10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.010 | ||
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.010 | ||
| Sp140 | SP140 nuclear body protein | 0.010 | ||
| Igtp | interferon gamma induced GTPase | 0.010 | ||
| Serinc5 | serine incorporator 5 | 0.010 | ||
| Stat1 | signal transducer and activator of transcription 1 | 0.010 |