IMP

Process View

Rattus norvegicus

12 genes annotated in rat

protein kinase c activating g protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).

Loading network...

In addition to gene-name show these genes:

Known genes in the process in rat Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein kinase c activating g protein coupled receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein kinase c activating g protein coupled receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.364
Adora2a	adenosine A2a receptor	0.239
Csf1	colony stimulating factor 1 (macrophage)	0.229
Mag	myelin-associated glycoprotein	0.165
Dspp	dentin sialophosphoprotein	0.163
Ciita	class II, major histocompatibility complex, transactivator	0.150
Ucn	urocortin	0.141
Chrm2	cholinergic receptor, muscarinic 2	0.137
Dio2	deiodinase, iodothyronine, type II	0.136
Lims1	LIM and senescent cell antigen-like domains 1	0.135
C5ar1	complement component 5a receptor 1	0.131
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.129
Rftn2	raftlin family member 2	0.112
Mog	myelin oligodendrocyte glycoprotein	0.089
Il9r	interleukin 9 receptor	0.087
Hpca	hippocalcin	0.084
Rgs9	regulator of G-protein signaling 9	0.082
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.081
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.078
Pax6	paired box 6	0.076
Prkg2	protein kinase, cGMP-dependent, type II	0.075
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.074
Itgam	integrin, alpha M	0.071
Nmbr	neuromedin B receptor	0.069
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.067
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.065
Oprk1	opioid receptor, kappa 1	0.065
Fgb	fibrinogen beta chain	0.064
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.063
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.063
Cxcr3	chemokine (C-X-C motif) receptor 3	0.062
Mobp	myelin-associated oligodendrocyte basic protein	0.059
Ar	androgen receptor	0.058
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.056
Tbxas1	thromboxane A synthase 1, platelet	0.054
Il1a	interleukin 1 alpha	0.054
Ednra	endothelin receptor type A	0.051
Hcrt	hypocretin	0.050
S1pr2	sphingosine-1-phosphate receptor 2	0.049
Grm6	glutamate receptor, metabotropic 6	0.049	Rat
Hand1	heart and neural crest derivatives expressed 1	0.047
Grip2	glutamate receptor interacting protein 2	0.045
Cybb	cytochrome b-245, beta polypeptide	0.044
Drd2	dopamine receptor D2	0.044
Lep	leptin	0.043
Slco2b1	solute carrier organic anion transporter family, member 2b1	0.042
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.041
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.041
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive	0.040
Adora1	adenosine A1 receptor	0.040	Rat
Adora3	adenosine A3 receptor	0.040	Rat
Bcl2	B-cell CLL/lymphoma 2	0.040
Cpa3	carboxypeptidase A3, mast cell	0.036
Gja6	gap junction protein, alpha 6	0.036
Gzmk	granzyme K	0.036
Ptafr	platelet-activating factor receptor	0.033
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.033
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.033
Ptprz1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.032
Grip1	glutamate receptor interacting protein 1	0.031
Pla2g2c	phospholipase A2, group IIC	0.031
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.031
Cnga4	cyclic nucleotide gated channel alpha 4	0.031
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.031
Nrg1	neuregulin 1	0.030
Grm7	glutamate receptor, metabotropic 7	0.030
Trhr	thyrotropin releasing hormone receptor	0.030
Folh1	folate hydrolase 1	0.029
Ctsj	cathepsin J	0.028
Mchr1	melanin-concentrating hormone receptor 1	0.028
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.027
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.026
Tlr7	toll-like receptor 7	0.026
LOC286987	hemiferrin, transferrin-like protein	0.025
Dcc	deleted in colorectal carcinoma	0.025
Nfasc	neurofascin	0.024
Tlr4	toll-like receptor 4	0.024
Hcrtr2	hypocretin (orexin) receptor 2	0.024
Vipr2	vasoactive intestinal peptide receptor 2	0.024	Rat
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.023	Rat
Sell	selectin L	0.022
Gria2	glutamate receptor, ionotropic, AMPA 2	0.022
Tacr1	tachykinin receptor 1	0.022
Folr2	folate receptor 2 (fetal)	0.022
Igsf1	immunoglobulin superfamily, member 1	0.022
Iapp	islet amyloid polypeptide	0.022
Acrv1	acrosomal vesicle protein 1	0.022
Fgf14	fibroblast growth factor 14	0.022
Mmp12	matrix metallopeptidase 12	0.021
Kcnj16	potassium inwardly-rectifying channel, subfamily J, member 16	0.021
Socs3	suppressor of cytokine signaling 3	0.021
Znf483	zinc finger protein 483	0.021
Hpgds	hematopoietic prostaglandin D synthase	0.021
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.021
Galr2	galanin receptor 2	0.021
Cd38	CD38 molecule	0.020
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.019
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.019
Olr1078	olfactory receptor 1078	0.019
Cckar	cholecystokinin A receptor	0.019
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.019
Marcks	myristoylated alanine rich protein kinase C substrate	0.019
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.019
Cd86	CD86 molecule	0.019
Pde5a	phosphodiesterase 5A, cGMP-specific	0.019
Glp1r	glucagon-like peptide 1 receptor	0.019	Rat
RGD1559748	similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)	0.018
Gabra6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	0.018
Fev	FEV (ETS oncogene family)	0.018
Ccr5	chemokine (C-C motif) receptor 5	0.018
Gip	gastric inhibitory polypeptide	0.018
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.018
Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.018
Lepr	leptin receptor	0.018
Ncan	neurocan	0.018
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.017
Crhr2	corticotropin releasing hormone receptor 2	0.017
Figf	c-fos induced growth factor	0.017
Calcrl	calcitonin receptor-like	0.017	Rat
Sstr5	somatostatin receptor 5	0.017
Nrarp	Notch-regulated ankyrin repeat protein	0.017
Cxcl2	chemokine (C-X-C motif) ligand 2	0.017
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.017
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	0.017
Glra1	glycine receptor, alpha 1	0.016
Cxcl6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.016
Tff1	trefoil factor 1	0.016
Crhr1	corticotropin releasing hormone receptor 1	0.016	Rat
Gad1	glutamate decarboxylase 1	0.016
Phkg1	phosphorylase kinase, gamma 1	0.016
Fam148b	family with sequence similarity 148, member B	0.016
Avpr1b	arginine vasopressin receptor 1B	0.016
Pip	prolactin induced protein	0.016
Mep1a	meprin 1 alpha	0.016
Prl3d4	prolactin family 3, subfamily d, member 4	0.015
Gpr88	G-protein coupled receptor 88	0.015
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.015
Vip	vasoactive intestinal peptide	0.015
Clec4a3	C-type lectin domain family 4, member a3	0.015
Vom2r27	vomeronasal 2 receptor, 27	0.015
Pdyn	prodynorphin	0.015
Ptgfr	prostaglandin F receptor	0.015
Grin2c	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.014
Zic1	Zic family member 1 (odd-paired homolog, Drosophila)	0.014
Olr1696	olfactory receptor 1696	0.014
Agtr1a	angiotensin II receptor, type 1a	0.014	Rat
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.014
Il1rn	interleukin 1 receptor antagonist	0.014
Mgat5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	0.014
Igf1	insulin-like growth factor 1	0.014
Cxcl13	chemokine (C-X-C motif) ligand 13	0.013
Ppyr1	pancreatic polypeptide receptor 1	0.013
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.013
Trhr2	thyrotropin releasing hormone receptor 2	0.013
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.013
Olr416	olfactory receptor 416	0.013
Faslg	Fas ligand (TNF superfamily, member 6)	0.013
Slc22a25	solute carrier family 22, member 25	0.012
Atxn1	ataxin 1	0.012
Fxyd4	FXYD domain-containing ion transport regulator 4	0.012
Fgfr2	fibroblast growth factor receptor 2	0.012
Insrr	insulin receptor-related receptor	0.012
Cd4	Cd4 molecule	0.012
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.012
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.012
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.012
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.012
Nxph1	neurexophilin 1	0.012
Smad3	SMAD family member 3	0.012
Arl11	ADP-ribosylation factor-like 11	0.012
Prph2	peripherin 2	0.012
Pnlip	pancreatic lipase	0.011
Fgf7	fibroblast growth factor 7	0.011
Foxg1	forkhead box G1	0.011
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.011
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.011
Dhrs9	dehydrogenase/reductase (SDR family) member 9	0.011
Mrgprf	MAS-related GPR, member F	0.011
Shox2	short stature homeobox 2	0.011
Klk6	kallikrein related-peptidase 6	0.011
Dnase1	deoxyribonuclease I	0.011
Smgb	neonatal submandibular gland protein B	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Fam83f	family with sequence similarity 83, member F	0.011
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.011
Tbx2	T-box 2	0.011
Slc16a8	solute carrier family 16, member 8 (monocarboxylic acid transporter 3)	0.011
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.011
Spata9	spermatogenesis associated 9	0.011
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.010
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.010	Rat
Pde1b	phosphodiesterase 1B, calmodulin-dependent	0.010
Col5a2	collagen, type V, alpha 2	0.010
Cga	glycoprotein hormones, alpha polypeptide	0.010
Gng7	guanine nucleotide binding protein (G protein), gamma 7	0.010