IMP
Process View
The network for 'negative regulation of bone mineralization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of bone mineralization
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CCL5 | chemokine (C-C motif) ligand 5 | 1.000 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 1.000 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.992 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.918 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.907 | |
| IL8 | interleukin 8 | 0.893 | |
| CCR4 | chemokine (C-C motif) receptor 4 | 0.878 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.795 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.735 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.583 | |
| CCL3 | chemokine (C-C motif) ligand 3 | 0.520 | |
| IFNG | interferon, gamma | 0.497 | |
| IL2RB | interleukin 2 receptor, beta | 0.470 | |
| CCR2 | chemokine (C-C motif) receptor 2 | 0.465 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.464 | |
| IL1B | interleukin 1, beta | 0.417 | |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.328 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.270 | |
| LTA | lymphotoxin alpha (TNF superfamily, member 1) | 0.244 | |
| VCAN | versican | 0.222 | |
| IL10 | interleukin 10 | 0.217 | |
| IRF4 | interferon regulatory factor 4 | 0.188 | |
| CCL11 | chemokine (C-C motif) ligand 11 | 0.174 | |
| IL6 | interleukin 6 (interferon, beta 2) | 0.169 | |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.165 | |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.162 | |
| KDM2B | lysine (K)-specific demethylase 2B | 0.154 | |
| PDCD6IP | programmed cell death 6 interacting protein | 0.148 | |
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.145 | |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.139 | |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.136 | |
| CD40LG | CD40 ligand | 0.133 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.121 | |
| CXCR3 | chemokine (C-X-C motif) receptor 3 | 0.091 | |
| SLAMF7 | SLAM family member 7 | 0.089 | |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.089 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.062 | |
| MATK | megakaryocyte-associated tyrosine kinase | 0.062 | |
| TNF | tumor necrosis factor | 0.050 | |
| IDE | insulin-degrading enzyme | 0.047 | |
| CCL7 | chemokine (C-C motif) ligand 7 | 0.046 | |
| CLEC7A | C-type lectin domain family 7, member A | 0.046 | |
| IL2RG | interleukin 2 receptor, gamma | 0.045 | |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 0.044 | |
| RGS1 | regulator of G-protein signaling 1 | 0.040 | |
| IL16 | interleukin 16 (lymphocyte chemoattractant factor) | 0.039 | |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.038 | |
| CCR3 | chemokine (C-C motif) receptor 3 | 0.037 | |
| CCR6 | chemokine (C-C motif) receptor 6 | 0.036 | |
| CD86 | CD86 molecule | 0.035 | |
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.034 | |
| MMP9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.034 | |
| IL1F5 | interleukin 1 family, member 5 (delta) | 0.034 | |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.033 | |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | 0.033 | |
| IL1R2 | interleukin 1 receptor, type II | 0.029 | |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 0.029 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.029 | |
| SELE | selectin E | 0.027 | |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.027 | |
| SOCS3 | suppressor of cytokine signaling 3 | 0.026 | |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.025 | |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.025 | |
| CXCR2 | chemokine (C-X-C motif) receptor 2 | 0.024 | |
| IL21R | interleukin 21 receptor | 0.022 | |
| IL2RA | interleukin 2 receptor, alpha | 0.022 | |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.022 | |
| CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 0.021 | |
| CLEC10A | C-type lectin domain family 10, member A | 0.021 | |
| IL10RA | interleukin 10 receptor, alpha | 0.020 | |
| ALB | albumin | 0.020 | |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.020 | |
| CCR8 | chemokine (C-C motif) receptor 8 | 0.019 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.019 | |
| CCR9 | chemokine (C-C motif) receptor 9 | 0.019 | |
| CCL1 | chemokine (C-C motif) ligand 1 | 0.018 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.017 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.017 | |
| IL18RAP | interleukin 18 receptor accessory protein | 0.017 | |
| IL7R | interleukin 7 receptor | 0.017 | |
| FPR3 | formyl peptide receptor 3 | 0.015 | |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.015 | |
| CCL21 | chemokine (C-C motif) ligand 21 | 0.015 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.014 | |
| CD2 | CD2 molecule | 0.013 | |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.012 | |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.012 | |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 0.012 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.012 | |
| CD84 | CD84 molecule | 0.011 | |
| TBX21 | T-box 21 | 0.011 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.011 | |
| CD163 | CD163 molecule | 0.011 | |
| EBI3 | Epstein-Barr virus induced 3 | 0.011 | |
| IL1RN | interleukin 1 receptor antagonist | 0.011 | |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.011 | |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.010 | |
| CSF1R | colony stimulating factor 1 receptor | 0.010 | |
| IL13 | interleukin 13 | 0.010 | |
| C3AR1 | complement component 3a receptor 1 | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Fgfr2 | fibroblast growth factor receptor 2 | 0.431 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.223 | |
| Sox4 | SRY-box containing gene 4 | 0.213 | |
| Fgf8 | fibroblast growth factor 8 | 0.190 | |
| Pkd1 | polycystic kidney disease 1 homolog | 0.178 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.162 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.158 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.139 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.137 | |
| Vegfa | vascular endothelial growth factor A | 0.135 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.128 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.121 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.120 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.116 | |
| Bmp4 | bone morphogenetic protein 4 | 0.097 | |
| Gata6 | GATA binding protein 6 | 0.095 | |
| Tbx1 | T-box 1 | 0.089 | |
| She | src homology 2 domain-containing transforming protein E | 0.084 | |
| Pax3 | paired box gene 3 | 0.070 | |
| Pax2 | paired box gene 2 | 0.066 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.060 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.058 | |
| Wt1 | Wilms tumor 1 homolog | 0.058 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.056 | |
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.054 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.052 | |
| Notch3 | Notch gene homolog 3 (Drosophila) | 0.050 | |
| Nf1 | neurofibromatosis 1 | 0.044 | |
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.044 | |
| Jag1 | jagged 1 | 0.044 | |
| Pdgfrb | platelet derived growth factor receptor, beta polypeptide | 0.041 | |
| Efs | embryonal Fyn-associated substrate | 0.040 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.039 | |
| Bnc1 | basonuclin 1 | 0.039 | |
| Sox17 | SRY-box containing gene 17 | 0.039 | |
| Ldlr | low density lipoprotein receptor | 0.038 | |
| Smo | smoothened homolog (Drosophila) | 0.038 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.037 | |
| Sox7 | SRY-box containing gene 7 | 0.037 | |
| Efnb2 | ephrin B2 | 0.037 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.036 | |
| Shh | sonic hedgehog | 0.035 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.034 | |
| Egln1 | EGL nine homolog 1 (C. elegans) | 0.034 | |
| Src | Rous sarcoma oncogene | 0.033 | |
| Ptpn14 | protein tyrosine phosphatase, non-receptor type 14 | 0.032 | |
| Fgf10 | fibroblast growth factor 10 | 0.032 | |
| Gas1 | growth arrest specific 1 | 0.031 | |
| Tbx2 | T-box 2 | 0.029 | |
| Mitf | microphthalmia-associated transcription factor | 0.027 | |
| Meox2 | mesenchyme homeobox 2 | 0.026 | |
| Fzd2 | frizzled homolog 2 (Drosophila) | 0.026 | |
| Hoxa1 | homeobox A1 | 0.025 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.025 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.024 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.023 | |
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.023 | |
| Msx1 | homeobox, msh-like 1 | 0.023 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.022 | |
| Figf | c-fos induced growth factor | 0.022 | |
| Efnb1 | ephrin B1 | 0.022 | |
| Rb1 | retinoblastoma 1 | 0.022 | |
| Hoxa5 | homeobox A5 | 0.022 | |
| Tspan9 | tetraspanin 9 | 0.022 | |
| Fgf3 | fibroblast growth factor 3 | 0.022 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.021 | |
| Tcfap2c | transcription factor AP-2, gamma | 0.021 | |
| Mmp2 | matrix metallopeptidase 2 | 0.021 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.021 | |
| Emp2 | epithelial membrane protein 2 | 0.021 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.020 | |
| Foxc2 | forkhead box C2 | 0.020 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.019 | |
| Zfp503 | zinc finger protein 503 | 0.019 | |
| Fzd4 | frizzled homolog 4 (Drosophila) | 0.019 | |
| Ephb2 | Eph receptor B2 | 0.019 | |
| Tgfb1i1 | transforming growth factor beta 1 induced transcript 1 | 0.018 | |
| Epas1 | endothelial PAS domain protein 1 | 0.018 | |
| Tcf7l1 | transcription factor 7-like 1 (T-cell specific, HMG box) | 0.018 | |
| Nfatc2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.018 | |
| Rxra | retinoid X receptor alpha | 0.018 | |
| Slc4a1 | solute carrier family 4 (anion exchanger), member 1 | 0.018 | |
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.018 | |
| Hhex | hematopoietically expressed homeobox | 0.018 | |
| Gpc3 | glypican 3 | 0.017 | |
| Hey1 | hairy/enhancer-of-split related with YRPW motif 1 | 0.017 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.017 | |
| Six5 | sine oculis-related homeobox 5 homolog (Drosophila) | 0.017 | |
| Mrc2 | mannose receptor, C type 2 | 0.016 | |
| Idua | iduronidase, alpha-L- | 0.016 | |
| Epha1 | Eph receptor A1 | 0.016 | |
| Fyn | Fyn proto-oncogene | 0.016 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.016 | |
| Lama5 | laminin, alpha 5 | 0.015 | |
| Alx3 | aristaless-like homeobox 3 | 0.015 | |
| Hoxb4 | homeobox B4 | 0.015 | |
| Tcf21 | transcription factor 21 | 0.015 | |
| Gata4 | GATA binding protein 4 | 0.015 | |
| Mmp11 | matrix metallopeptidase 11 | 0.015 | |
| Flt1 | FMS-like tyrosine kinase 1 | 0.015 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Alb | albumin | 0.011 |