The network for 'activation of phospholipase d activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of phospholipase d activity

Any process that initiates the activity of inactive phospholipase D.

Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 0.997
ARFIP2 ADP-ribosylation factor interacting protein 2 0.856
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.817
CCL2 chemokine (C-C motif) ligand 2 0.795
CCL8 chemokine (C-C motif) ligand 8 0.676
CCL4 chemokine (C-C motif) ligand 4 0.609
CXCL9 chemokine (C-X-C motif) ligand 9 0.568
CCL5 chemokine (C-C motif) ligand 5 0.537
ARCN1 archain 1 0.372
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.368
CXCL13 chemokine (C-X-C motif) ligand 13 0.332
DPP4 dipeptidyl-peptidase 4 0.328
IDE insulin-degrading enzyme 0.311
IL1B interleukin 1, beta 0.271
VCAM1 vascular cell adhesion molecule 1 0.246
IL8 interleukin 8 0.242
IL6 interleukin 6 (interferon, beta 2) 0.168
CCR1 chemokine (C-C motif) receptor 1 0.148
CCL13 chemokine (C-C motif) ligand 13 0.125
CXCL3 chemokine (C-X-C motif) ligand 3 0.118
RGS1 regulator of G-protein signaling 1 0.096
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 0.087
CCL7 chemokine (C-C motif) ligand 7 0.087
TMED2 transmembrane emp24 domain trafficking protein 2 0.078
IL10 interleukin 10 0.076
IL18RAP interleukin 18 receptor accessory protein 0.072
CD83 CD83 molecule 0.068
SERP1 stress-associated endoplasmic reticulum protein 1 0.068
ZNF71 zinc finger protein 71 0.067
CCR7 chemokine (C-C motif) receptor 7 0.065
CCDC115 coiled-coil domain containing 115 0.057
IFNG interferon, gamma 0.057
RAB11A RAB11A, member RAS oncogene family 0.056
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.052
RAB1A RAB1A, member RAS oncogene family 0.050
CYTH2 cytohesin 2 0.050
GNLY granulysin 0.048
SELE selectin E 0.047
ADAMDEC1 ADAM-like, decysin 1 0.044
SLAMF8 SLAM family member 8 0.044
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.043
IL2RB interleukin 2 receptor, beta 0.043
FPR3 formyl peptide receptor 3 0.042
CXCL11 chemokine (C-X-C motif) ligand 11 0.042
TRAM1 translocation associated membrane protein 1 0.040
CXCL10 chemokine (C-X-C motif) ligand 10 0.037
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.037
CCL22 chemokine (C-C motif) ligand 22 0.037
C4orf14 chromosome 4 open reading frame 14 0.035
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.035
BET1 blocked early in transport 1 homolog (S. cerevisiae) 0.035
CXCL2 chemokine (C-X-C motif) ligand 2 0.035
CH25H cholesterol 25-hydroxylase 0.034
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.034
CCL3L3 chemokine (C-C motif) ligand 3-like 3 0.032
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.032
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.032
SLAMF7 SLAM family member 7 0.031
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.031
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.030
WBP11 WW domain binding protein 11 0.028
ARRB1 arrestin, beta 1 0.027
VHL von Hippel-Lindau tumor suppressor 0.027
INHBA inhibin, beta A 0.027
SAR1B SAR1 homolog B (S. cerevisiae) 0.026
TNF tumor necrosis factor 0.026
CD163 CD163 molecule 0.026
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.025
TMEM50B transmembrane protein 50B 0.024
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.024
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.023
CCR4 chemokine (C-C motif) receptor 4 0.023
C1QB complement component 1, q subcomponent, B chain 0.023
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.023
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.022
CXCL5 chemokine (C-X-C motif) ligand 5 0.022
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.022
C12orf23 chromosome 12 open reading frame 23 0.022
CAPNS1 calpain, small subunit 1 0.022
CCL19 chemokine (C-C motif) ligand 19 0.021
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.020
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.020
GLT8D1 glycosyltransferase 8 domain containing 1 0.020
DARC Duffy blood group, chemokine receptor 0.019
FKBP1A FK506 binding protein 1A, 12kDa 0.019
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.019
CCL3 chemokine (C-C motif) ligand 3 0.019
CFL1 cofilin 1 (non-muscle) 0.018
IL1RN interleukin 1 receptor antagonist 0.018
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.018
APOC1 apolipoprotein C-I 0.018
NKG7 natural killer cell group 7 sequence 0.018
MSC musculin 0.018
XCL2 chemokine (C motif) ligand 2 0.017
UBD ubiquitin D 0.017
CD69 CD69 molecule 0.017
YIPF6 Yip1 domain family, member 6 0.017
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.016
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.016
NUCB2 nucleobindin 2 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Copb1 coatomer protein complex, subunit beta 1 0.426
Rab1b RAB1B, member RAS oncogene family 0.333
Tmed2 transmembrane emp24 domain trafficking protein 2 0.292
Bet1 blocked early in transport 1 homolog (S. cerevisiae) 0.231
Eef2 eukaryotic translation elongation factor 2 0.226
Rap1b RAP1B, member of RAS oncogene family 0.222
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.181
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.165
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.098
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.098
Syngr2 synaptogyrin 2 0.086
Ddx3x DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.082
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.082
Arf4 ADP-ribosylation factor 4 0.076
Cdk7 cyclin-dependent kinase 7 0.074
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.069
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.066
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.064
Arcn1 archain 1 0.060
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.059
Cyth1 cytohesin 1 0.057
Azin1 antizyme inhibitor 1 0.050
Ccnd3 cyclin D3 0.049
Il2rb interleukin 2 receptor, beta 0.048
Arf1 ADP-ribosylation factor 1 0.048
Akap1 A kinase (PRKA) anchor protein 1 0.041
Serp1 stress-associated endoplasmic reticulum protein 1 0.041
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.039
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.038
Cyfip2 cytoplasmic FMR1 interacting protein 2 0.038
Hnrnpf heterogeneous nuclear ribonucleoprotein F 0.036
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.034
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.033
Rpl4 ribosomal protein L4 0.032
Fgfr1 Fibroblast growth factor receptor 1 0.031
Hist1h1a histone cluster 1, H1a 0.031
Stx1b syntaxin 1B 0.031
Magt1 magnesium transporter 1 0.031
Tmed9 transmembrane emp24 protein transport domain containing 9 0.029
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.029
Shank2 SH3 and multiple ankyrin repeat domains 2 0.028
Epas1 endothelial PAS domain protein 1 0.027
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.027
Anxa6 annexin A6 0.026
Usf2 upstream transcription factor 2, c-fos interacting 0.025
Nkg7 natural killer cell group 7 sequence 0.025
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.024
Camk4 calcium/calmodulin-dependent protein kinase IV 0.023
Unc5a unc-5 homolog A (C. elegans) 0.023
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.023
Hk1 hexokinase 1 0.022
Scn3b sodium channel, voltage-gated, type III, beta 0.022
Papola poly (A) polymerase alpha 0.021
Sec11a SEC11 homolog A (S. cerevisiae) 0.021
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.021
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.020
Eif5 eukaryotic translation initiation factor 5 0.020
Arl5a ADP-ribosylation factor-like 5A 0.020
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.020
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.020
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.019
Csnk1g2 casein kinase 1, gamma 2 0.019
Sirpa signal-regulatory protein alpha 0.019
Pctk1 PCTAIRE protein kinase 1 0.019
RGD1311122 similar to RIKEN cDNA 1110003E01 0.019
Nrgn neurogranin 0.019
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.019
RT1-Ba RT1 class II, locus Ba 0.019
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.018
Accn1 amiloride-sensitive cation channel 1, neuronal 0.018
Stat6 signal transducer and activator of transcription 6 0.017
Syn1 synapsin I 0.017
Epn1 Epsin 1 0.017
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.017
Snca synuclein, alpha (non A4 component of amyloid precursor) 0.017
Gria2 glutamate receptor, ionotropic, AMPA 2 0.017
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.017
Igh-6 immunoglobulin heavy chain 6 0.016
LOC100360986 mCG1035404-like 0.016
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.016
Dstn destrin 0.016
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.016
Efnb1 ephrin B1 0.016
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.016
Rab11b RAB11B, member RAS oncogene family 0.016
Gtf2b general transcription factor IIB 0.016
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.015
Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.015
Akt1s1 AKT1 substrate 1 (proline-rich) 0.015
Gzmk granzyme K 0.015
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.015
Syn2 synapsin II 0.015
Map2 microtubule-associated protein 2 0.015
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.015
Extl3 exostoses (multiple)-like 3 0.015
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.015
Cd4 Cd4 molecule 0.015
Aqp4 aquaporin 4 0.015
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.015
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism