The network for 'regulated secretory pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulated secretory pathway

A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.

Rattus norvegicus
Name Description Probability Func Analog Organism
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.250
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.146
Litaf lipopolysaccharide-induced TNF factor 0.126
Tgfbr3 transforming growth factor, beta receptor III 0.084
Ciita class II, major histocompatibility complex, transactivator 0.081
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.078
Cybb cytochrome b-245, beta polypeptide 0.064
Inpp5d inositol polyphosphate-5-phosphatase D 0.062
Hck hemopoietic cell kinase 0.061
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.056
Calm1 calmodulin 1 0.055
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.055
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.051
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.050
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.049
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.046
Adap1 ArfGAP with dual PH domains 1 0.045
Syt3 synaptotagmin III 0.044
Nptn neuroplastin 0.044
Csf1 colony stimulating factor 1 (macrophage) 0.042
Arl11 ADP-ribosylation factor-like 11 0.041
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.039
Dock8 dedicator of cytokinesis 8 0.037
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.036
Fut2 fucosyltransferase 2 (secretor status included) 0.035
Atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.035
Ccr5 chemokine (C-C motif) receptor 5 0.034
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.033
Arhgap25 Rho GTPase activating protein 25 0.033
Ptafr platelet-activating factor receptor 0.032
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.032
Hpgds hematopoietic prostaglandin D synthase 0.031
Stxbp1 syntaxin binding protein 1 0.030
Impa1 Inositol (myo)-1(or 4)-monophosphatase 1 0.030
Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 0.030
Cxcr3 chemokine (C-X-C motif) receptor 3 0.029
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.029
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.029
Il2rb interleukin 2 receptor, beta 0.029
Syt7 synaptotagmin VII 0.028
Ptprc protein tyrosine phosphatase, receptor type, C 0.028
Cfp complement factor properdin 0.027
Sirpa signal-regulatory protein alpha 0.026
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.026
Cd86 CD86 molecule 0.026
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.026
Arhgap4 Rho GTPase activating protein 4 0.025
Cd38 CD38 molecule 0.025
Morf4l2 mortality factor 4 like 2 0.024
RGD1559748 similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein) 0.024
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.024
Kcnk1 potassium channel, subfamily K, member 1 0.024
Folr2 folate receptor 2 (fetal) 0.024
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.024
Tuba1c tubulin, alpha 1C 0.023
Pgam1 phosphoglycerate mutase 1 (brain) 0.022
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.022
Adar adenosine deaminase, RNA-specific 0.022
Actg1 actin, gamma 1 0.022
Tm9sf2 transmembrane 9 superfamily member 2 0.021
C5ar1 complement component 5a receptor 1 0.021
Cd68 Cd68 molecule 0.021
Nsf N-ethylmaleimide-sensitive factor 0.020
Crhbp corticotropin releasing hormone binding protein 0.020
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.019
Phox2a paired-like homeobox 2a 0.019
Gp2 glycoprotein 2 (zymogen granule membrane) 0.019
Mapk10 mitogen activated protein kinase 10 0.018
Gnaz guanine nucleotide binding protein (G protein), alpha z polypeptide 0.018
RGD1307722 similar to hypothetical protein MGC20700 0.018
Ctse cathepsin E 0.018
Cltc clathrin, heavy chain (Hc) 0.018
Itgam integrin, alpha M 0.018
Pitpna phosphatidylinositol transfer protein, alpha 0.018
Il2rg interleukin 2 receptor, gamma 0.018
Slc14a1 solute carrier family 14 (urea transporter), member 1 0.017
Rabac1 Rab acceptor 1 (prenylated) 0.017
Grm8 glutamate receptor, metabotropic 8 0.017
Igsf6 immunoglobulin superfamily, member 6 0.017
Zic1 Zic family member 1 (odd-paired homolog, Drosophila) 0.017
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.017
Tpsab1 tryptase alpha/beta 1 0.016
Adora2a adenosine A2a receptor 0.016
Hk1 hexokinase 1 0.016
Notch4 Notch homolog 4 (Drosophila) 0.016
Dnase1l3 deoxyribonuclease 1-like 3 0.016
Gja6 gap junction protein, alpha 6 0.016
Eif4h eukaryotic translation initiation factor 4H 0.016
C1ql1 complement component 1, q subcomponent-like 1 0.016
Itgad integrin, alpha D 0.016
Kynu kynureninase (L-kynurenine hydrolase) 0.016
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.016
RT1-Ba RT1 class II, locus Ba 0.016
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.016
Snap25 synaptosomal-associated protein 25 0.016
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.015
Clstn3 calsyntenin 3 0.015
Kcnip3 Kv channel interacting protein 3, calsenilin 0.015
Nras neuroblastoma ras oncogene 0.015
Rap1b RAP1B, member of RAS oncogene family 0.015
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.013
ZK686.3 Protein ZK686.3 0.012
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stnA stoned A 0.043
Khc Kinesin heavy chain 0.016
endoA endophilin A 0.016
lap like-AP180 0.015
mbc myoblast city 0.014
n-syb n-synaptobrevin 0.012
Gad1 Glutamic acid decarboxylase 1 0.011
mi minus 0.011
Rab5 Rab-protein 5 0.011
Mekk1 CG7717 gene product from transcript CG7717-RB 0.010
cdi center divider 0.010
Pk61C Protein kinase 61C 0.010
Pabp2 CG2163 gene product from transcript CG2163-RA 0.010
par-1 CG8201 gene product from transcript CG8201-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.572
CCR5 chemokine (C-C motif) receptor 5 0.488
EGFR epidermal growth factor receptor 0.294
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.282
PLCG1 phospholipase C, gamma 1 0.221
BLNK B-cell linker 0.211
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.206
LAT linker for activation of T cells 0.203
GRB2 growth factor receptor-bound protein 2 0.186
GBA glucosidase, beta, acid 0.185
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.164
SYK spleen tyrosine kinase 0.155
CCL4 chemokine (C-C motif) ligand 4 0.150
SNAP23 synaptosomal-associated protein, 23kDa 0.146
UBASH3B ubiquitin associated and SH3 domain containing B 0.123
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.120
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.116
C19orf50 chromosome 19 open reading frame 50 0.111
VEGFA vascular endothelial growth factor A 0.089
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.085
EEA1 early endosome antigen 1 0.084
PPL periplakin 0.081
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.071
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.062
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.057
GAB1 GRB2-associated binding protein 1 0.056
CCL5 chemokine (C-C motif) ligand 5 0.056
IL2RG interleukin 2 receptor, gamma 0.056
RAB14 RAB14, member RAS oncogene family 0.053
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.048
CCL2 chemokine (C-C motif) ligand 2 0.045
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.044
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.044
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.042
CCR7 chemokine (C-C motif) receptor 7 0.042
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.042
CXCL9 chemokine (C-X-C motif) ligand 9 0.041
VAV1 vav 1 guanine nucleotide exchange factor 0.041
TFF1 trefoil factor 1 0.038
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.038
CCR1 chemokine (C-C motif) receptor 1 0.036
ZNF746 zinc finger protein 746 0.036
SLA Src-like-adaptor 0.035
BTK Bruton agammaglobulinemia tyrosine kinase 0.035
DPP4 dipeptidyl-peptidase 4 0.034
CXCL10 chemokine (C-X-C motif) ligand 10 0.034
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.032
CARD11 caspase recruitment domain family, member 11 0.032
ANXA4 annexin A4 0.031
PTPRJ protein tyrosine phosphatase, receptor type, J 0.030
COPB1 coatomer protein complex, subunit beta 1 0.030
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.029
CLASP1 cytoplasmic linker associated protein 1 0.029
CDH5 cadherin 5, type 2 (vascular endothelium) 0.029
IL4 interleukin 4 0.028
CXCL2 chemokine (C-X-C motif) ligand 2 0.027
IL7R interleukin 7 receptor 0.026
KRT8 keratin 8 0.026
CCL13 chemokine (C-C motif) ligand 13 0.026
CCL3 chemokine (C-C motif) ligand 3 0.025
RAB10 RAB10, member RAS oncogene family 0.025
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.024
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.024
ITM2B integral membrane protein 2B 0.024
TNF tumor necrosis factor 0.024
SNAP25 synaptosomal-associated protein, 25kDa 0.024
RAB5A RAB5A, member RAS oncogene family 0.024
CCL22 chemokine (C-C motif) ligand 22 0.023
STX12 syntaxin 12 0.021
IFNG interferon, gamma 0.021
COPA coatomer protein complex, subunit alpha 0.021
CAV1 caveolin 1, caveolae protein, 22kDa 0.021
SOS1 son of sevenless homolog 1 (Drosophila) 0.021
PDGFA platelet-derived growth factor alpha polypeptide 0.021
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.021
CMIP c-Maf-inducing protein 0.020
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.020
IL10 interleukin 10 0.020
CRH corticotropin releasing hormone 0.019
MLPH melanophilin 0.019
IL4R interleukin 4 receptor 0.019
CCL7 chemokine (C-C motif) ligand 7 0.019
IL2RB interleukin 2 receptor, beta 0.019
VCAM1 vascular cell adhesion molecule 1 0.018
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.018
RABIF RAB interacting factor 0.018
FGFR1 fibroblast growth factor receptor 1 0.017
CCL8 chemokine (C-C motif) ligand 8 0.017
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.017
IL1B interleukin 1, beta 0.017
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.016
ARCN1 archain 1 0.016
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.016
INSR insulin receptor 0.016
KITLG KIT ligand 0.015
SDCBP syndecan binding protein (syntenin) 0.015
HEXB hexosaminidase B (beta polypeptide) 0.015
GSK3B glycogen synthase kinase 3 beta 0.015
SOS2 son of sevenless homolog 2 (Drosophila) 0.015
PLEK pleckstrin 0.015
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Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 0.943
Inpp5d inositol polyphosphate-5-phosphatase D 0.931
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.930
Ptprc protein tyrosine phosphatase, receptor type, C 0.824
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.728
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.726
Dok2 docking protein 2 0.676
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.666
Mefv Mediterranean fever 0.542
Il10ra interleukin 10 receptor, alpha 0.540
Clec4n C-type lectin domain family 4, member n 0.537
Csf1r colony stimulating factor 1 receptor 0.522
Ccr1 chemokine (C-C motif) receptor 1 0.515
Cd19 CD19 antigen 0.511
Ifng interferon gamma 0.500
Ccr6 chemokine (C-C motif) receptor 6 0.448
Msr1 macrophage scavenger receptor 1 0.443
C3ar1 complement component 3a receptor 1 0.437
Ptk2 PTK2 protein tyrosine kinase 2 0.430
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.373
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.372
Prf1 perforin 1 (pore forming protein) 0.355
C5ar1 complement component 5a receptor 1 0.355
Cd4 CD4 antigen 0.341
Grb2 growth factor receptor bound protein 2 0.331
Hcst hematopoietic cell signal transducer 0.311
Fcgr1 Fc receptor, IgG, high affinity I 0.291
Cd22 CD22 antigen 0.276
Cxcr3 chemokine (C-X-C motif) receptor 3 0.266
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.264
Tyrobp TYRO protein tyrosine kinase binding protein 0.260
Nfam1 Nfat activating molecule with ITAM motif 1 0.252
Foxp3 forkhead box P3 0.249
Il4 interleukin 4 0.243
Ccl2 chemokine (C-C motif) ligand 2 0.216
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.216
Fcgr2b Fc receptor, IgG, low affinity IIb 0.215
Tbxas1 thromboxane A synthase 1, platelet 0.215
Grap2 GRB2-related adaptor protein 2 0.210
Cbl Casitas B-lineage lymphoma 0.198
Trpv1 transient receptor potential cation channel, subfamily V, member 1 0.190
Prdm1 PR domain containing 1, with ZNF domain 0.177
AF251705 cDNA sequence AF251705 0.176
Cd180 CD180 antigen 0.173
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.173
Gab2 growth factor receptor bound protein 2-associated protein 2 0.168
Xcr1 chemokine (C motif) receptor 1 0.161
Ccr5 chemokine (C-C motif) receptor 5 0.158
Fcrla Fc receptor-like A 0.158
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.156
Itk IL2-inducible T-cell kinase 0.155
Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 0.154
Fcgr3 Fc receptor, IgG, low affinity III 0.153
Anxa1 annexin A1 0.153
Mlph melanophilin 0.152
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.144
4632428N05Rik RIKEN cDNA 4632428N05 gene 0.144
Stx11 syntaxin 11 0.144
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.143
Mmp9 matrix metallopeptidase 9 0.140
S1pr4 sphingosine-1-phosphate receptor 4 0.138
Met met proto-oncogene 0.130
Itgax integrin alpha X 0.123
Clec4d C-type lectin domain family 4, member d 0.123
Clec7a C-type lectin domain family 7, member a 0.121
Ccl6 chemokine (C-C motif) ligand 6 0.120
Ccl9 chemokine (C-C motif) ligand 9 0.119
Was Wiskott-Aldrich syndrome homolog (human) 0.118
Cd247 CD247 antigen 0.116
Myo1f myosin IF 0.113
Il1rn interleukin 1 receptor antagonist 0.113
Lyz2 lysozyme 2 0.112
Fut4 fucosyltransferase 4 0.105
BC013712 cDNA sequence BC013712 0.103
Dok1 docking protein 1 0.102
Cd68 CD68 antigen 0.102
Itgal integrin alpha L 0.099
Tlr2 toll-like receptor 2 0.096
Ncf1 neutrophil cytosolic factor 1 0.096
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.096
Ncf4 neutrophil cytosolic factor 4 0.095
Lamp2 lysosomal-associated membrane protein 2 0.095
Cx3cr1 chemokine (C-X3-C) receptor 1 0.095
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.089
Batf basic leucine zipper transcription factor, ATF-like 0.084
Cybb cytochrome b-245, beta polypeptide 0.084
Fgd3 FYVE, RhoGEF and PH domain containing 3 0.084
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.083
Ptafr platelet-activating factor receptor 0.081
Mpeg1 macrophage expressed gene 1 0.081
Il2 interleukin 2 0.080
Snai1 snail homolog 1 (Drosophila) 0.080
Syp synaptophysin 0.080
Galnt6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 0.079
Aif1 allograft inflammatory factor 1 0.079
Igsf6 immunoglobulin superfamily, member 6 0.079
Hrh1 histamine receptor H1 0.078
Mrc1 mannose receptor, C type 1 0.078
Mitf microphthalmia-associated transcription factor 0.078
Cnr2 cannabinoid receptor 2 (macrophage) 0.077
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism