The network for 'zymogen activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

zymogen activation

The proteolytic processing of an inactive enzyme to an active form.

Danio rerio
Name Description Probability Func Analog Organism
caspa caspase a 0.393
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.309
mmp2 matrix metalloproteinase 2 0.228
ccng1 cyclin G1 0.192
mych myelocytomatosis oncogene homolog 0.187
myca myelocytomatosis oncogene a 0.187
stc1l stanniocalcin 1, like 0.174
lap3 leucine aminopeptidase 3 0.173
ahcy S-adenosylhomocysteine hydrolase 0.170
hspa9 heat shock protein 9 0.169
lamc3 laminin, gamma 3 0.160
ela2l elastase 2 like 0.143
ef1a elongation factor 1-alpha 0.141
si:rp71-39b20.7 si:rp71-39b20.7 0.114
sulf1 sulfatase 1 0.110
prdm5 PR domain containing 5 0.104
bmper BMP binding endothelial regulator 0.102
grhl1 grainyhead-like 1 (Drosophila) 0.102
LOC569128 hypothetical protein LOC569128 0.100
tfe3b transcription factor binding to IGHM enhancer 3b 0.100
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.095
col12a1 collagen, type XII, alpha 1 0.089
gata3 GATA-binding protein 3 0.089
epor erythropoietin receptor 0.085
dhfr dihydrofolate reductase 0.085
zgc:171553 zgc:171553 0.084
il8 interleukin 8 0.084
ncapg2 non-SMC condensin II complex, subunit G2 0.083
zgc:172161 zgc:172161 0.083
prmt1 protein arginine methyltransferase 1 0.083
bbc3 BCL2 binding component 3 0.082
matn4 matrilin 4 0.082
msh6 mutS homolog 6 (E. coli) 0.081
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.079
eif3s2 eukaryotic translation initiation factor 3, subunit 2 beta 0.079
ahr2 aryl hydrocarbon receptor 2 0.074
slc15a1b solute carrier family 15 (oligopeptide transporter), member 1b 0.074
s100a10b S100 calcium binding protein A10b 0.073
mycbp2 MYC binding protein 2 0.073
cdkn1a cyclin-dependent kinase inhibitor 1A 0.071
tmprss4a transmembrane protease, serine 4a 0.070
fabp2 fatty acid binding protein 2, intestinal 0.070
tecrb trans-2,3-enoyl-CoA reductase b 0.069
timp2b tissue inhibitor of metalloproteinase 2b 0.068
gpia glucose phosphate isomerase a 0.067
xirp2a xin actin-binding repeat containing 2a 0.064
lamc1 laminin, gamma 1 0.062
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.062
adipor1b adiponectin receptor 1b 0.061
zgc:113054 zgc:113054 0.060
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.060
rps15a ribosomal protein S15a 0.060
ctrb1 chymotrypsinogen B1 0.060
si:ch211-212m21.5 si:ch211-212m21.5 0.059
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.058
cntfr ciliary neurotrophic factor receptor 0.058
prdx4 peroxiredoxin 4 0.058
scxa scleraxis homolog A (mouse) 0.058
zgc:92237 zgc:92237 0.058
limk2 LIM domain kinase 2 0.057
tm4sf4 transmembrane 4 L six family member 4 0.056
pkz protein kinase containing Z-DNA binding domains 0.056
igf1rb insulin-like growth factor 1b receptor 0.056
gata5 GATA-binding protein 5 0.054
bcl2 B-cell leukemia/lymphoma 2 0.054
immt inner membrane protein, mitochondrial (mitofilin) 0.053
myl9 myosin, light polypeptide 9, regulatory 0.052
aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.052
loxl2b lysyl oxidase-like 2b 0.052
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.052
phospho1 phosphatase, orphan 1 0.052
cops4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.052
duox dual oxidase 0.051
zgc:66382 zgc:66382 0.051
fanci Fanconi anemia, complementation group I 0.051
ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.049
cd247l CD247 antigen like 0.049
anxa1a annexin A1a 0.049
atp1a3b ATPase, Na+/K+ transporting, alpha 3b polypeptide 0.048
scarb1 scavenger receptor class B, member 1 0.048
acat1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 0.048
mmp14b matrix metalloproteinase 14b (membrane-inserted) 0.047
atf3 activating transcription factor 3 0.047
fadd Fas (tnfrsf6)-associated via death domain 0.046
lox lysyl oxidase 0.046
timp2a tissue inhibitor of metalloproteinase 2a 0.045
tp53inp1 tumor protein p53 inducible nuclear protein 1 0.045
prim1 primase polypeptide 1 0.045
lgals2a lectin, galactoside-binding, soluble, 2a 0.045
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.045
mbtps1 membrane-bound transcription factor protease, site 1 0.045
zff9 zinc finger protein 9 0.044
stat1b signal transducer and activator of transcription 1b 0.044
sult3st1 sulfotransferase family 3, cytosolic sulfotransferase 1 0.044
rpsa ribosomal protein SA 0.043
adrb2a adrenergic receptor, beta 2a 0.043
il1b interleukin 1, beta and interleukin 1, beta 0.043
mical3 flavoprotein oxidoreductase MICAL3 0.043
ran ras-related nuclear protein 0.043
cldn15lb claudin 15-like b 0.042
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
imd immune deficiency 0.567
th thread 0.508
Dredd Death related ced-3/Nedd2-like protein 0.341
CG9772 CG9772 gene product from transcript CG9772-RB 0.294
egr eiger 0.291
Pli Pellino 0.273
PGRP-LC Peptidoglycan recognition protein LC 0.252
CG4030 CG4030 gene product from transcript CG4030-RA 0.248
Mcm3 Minichromosome maintenance 3 0.242
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.201
Spn28D Serpin 28D 0.186
Spn27A Serpin 27A 0.165
PGRP-SA Peptidoglycan recognition protein SA 0.152
Cyt-c-d Cytochrome c distal 0.147
Nc Nedd2-like caspase 0.137
grim CG4345 gene product from transcript CG4345-RA 0.125
CG5731 CG5731 gene product from transcript CG5731-RA 0.122
Df31 Decondensation factor 31 0.116
Ark Apaf-1-related-killer 0.112
Sra-1 specifically Rac1-associated protein 1 0.112
CG6361 CG6361 gene product from transcript CG6361-RA 0.107
Sox14 Sox box protein 14 0.103
Dcp-1 Death caspase-1 0.102
Trip1 CG8882 gene product from transcript CG8882-RA 0.090
CG13597 CG13597 gene product from transcript CG13597-RA 0.087
CG6426 CG6426 gene product from transcript CG6426-RA 0.083
Mst77F Male-specific transcript 77F 0.082
nec necrotic 0.079
CG12766 CG12766 gene product from transcript CG12766-RA 0.078
Fhos CG42610 gene product from transcript CG42610-RC 0.076
slow slowdown 0.076
Sp7 Serine protease 7 0.072
Mcm7 Minichromosome maintenance 7 0.071
XNP CG4548 gene product from transcript CG4548-RA 0.066
CG9691 CG9691 gene product from transcript CG9691-RB 0.065
Spn1 Serine protease inhibitor 1 0.064
Pkd2 Polycystic kidney disease gene-2 0.063
ird5 immune response deficient 5 0.061
jar jaguar 0.058
Idgf2 Imaginal disc growth factor 2 0.058
CG5146 CG5146 gene product from transcript CG5146-RA 0.057
RnrL Ribonucleoside diphosphate reductase large subunit 0.055
cathD CG1548 gene product from transcript CG1548-RA 0.053
wts warts 0.052
gsb gooseberry 0.049
msl-1 male-specific lethal 1 0.049
lea leak 0.048
eIF3-S8 CG4954 gene product from transcript CG4954-RA 0.048
dre4 CG1828 gene product from transcript CG1828-RB 0.048
HtrA2 CG8464 gene product from transcript CG8464-RA 0.047
Acp62F Accessory gland peptide 62F 0.045
alphaTub84D alpha-Tubulin at 84D 0.044
spz spatzle 0.044
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.043
CG8600 CG8600 gene product from transcript CG8600-RB 0.043
Pvf2 PDGF- and VEGF-related factor 2 0.041
CG34110 CG34110 gene product from transcript CG34110-RC 0.041
CG9372 CG9372 gene product from transcript CG9372-RA 0.040
Obp56d Odorant-binding protein 56d 0.040
CG14213 CG14213 gene product from transcript CG14213-RB 0.036
Uba2 Smt3 activating enzyme 2 0.034
yuri yuri gagarin 0.034
east enhanced adult sensory threshold 0.033
Art4 Arginine methyltransferase 4 0.033
lmg lemming 0.033
CG15917 CG15917 gene product from transcript CG15917-RA 0.032
Acp53C14a CG8626 gene product from transcript CG8626-RA 0.032
trio CG18214 gene product from transcript CG18214-RA 0.031
shark Src homology 2, ankyrin repeat, tyrosine kinase 0.031
ome omega 0.031
Lsp2 Larval serum protein 2 0.030
Traf4 TNF-receptor-associated factor 4 0.030
CG5902 CG5902 gene product from transcript CG5902-RB 0.030
5-HT7 Serotonin receptor 7 0.030
nullo CG14426 gene product from transcript CG14426-RB 0.030
CG18258 CG18258 gene product from transcript CG18258-RA 0.030
Aats-gly Glycyl-tRNA synthetase 0.029
Fer2LCH Ferritin 2 light chain homologue 0.029
Duox Dual oxidase 0.029
alphaTub85E alpha-Tubulin at 85E 0.028
vig vasa intronic gene 0.028
EndoG Endonuclease G 0.028
Bub1 Bub1 homologue 0.028
sw short wing 0.028
Fmr1 CG6203 gene product from transcript CG6203-RC 0.028
Atg8a Autophagy-specific gene 8a 0.028
RpL39 Ribosomal protein L39 0.028
Acp53C14b CG15616 gene product from transcript CG15616-RA 0.027
Mnt CG13316 gene product from transcript CG13316-RD 0.027
Nup75 Nucleoporin 75 0.026
l(2)05510 lethal (2) 05510 0.026
msopa male-specific opa containing gene 0.026
nocte no circadian temperature entrainment 0.026
Rbp1 RNA-binding protein 1 0.025
BG642163 CG34102 gene product from transcript CG34102-RA 0.025
enok enoki mushroom 0.025
vvl ventral veins lacking 0.025
iHog interference Hedgehog 0.025
yellow-c CG4182 gene product from transcript CG4182-RA 0.025
Mekk1 CG7717 gene product from transcript CG7717-RB 0.023
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.000
BCL2 B-cell CLL/lymphoma 2 1.000
BCL2L1 BCL2-like 1 0.999
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.999
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.994
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.991
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.982
SMN1 survival of motor neuron 1, telomeric 0.980
FAS Fas (TNF receptor superfamily, member 6) 0.979
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.967
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.954
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.941
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.940
BID BH3 interacting domain death agonist 0.935
S100B S100 calcium binding protein B 0.935
HIPK2 homeodomain interacting protein kinase 2 0.934
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.919
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.917
TP53 tumor protein p53 0.913
XIAP X-linked inhibitor of apoptosis 0.888
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.887
S100A6 S100 calcium binding protein A6 0.877
CFLAR CASP8 and FADD-like apoptosis regulator 0.860
RB1 retinoblastoma 1 0.857
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.856
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.845
NLRC4 NLR family, CARD domain containing 4 0.802
S100A8 S100 calcium binding protein A8 0.797
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.708
S100A9 S100 calcium binding protein A9 0.696
BAX BCL2-associated X protein 0.685
SMAD3 SMAD family member 3 0.658
S100A1 S100 calcium binding protein A1 0.651
COL4A1 collagen, type IV, alpha 1 0.640
ANXA2 annexin A2 0.637
PLAU plasminogen activator, urokinase 0.627
GGT1 gamma-glutamyltransferase 1 0.624
S100A4 S100 calcium binding protein A4 0.608
DAXX death-domain associated protein 0.575
COL4A2 collagen, type IV, alpha 2 0.544
FADD Fas (TNFRSF6)-associated via death domain 0.520
SMAD1 SMAD family member 1 0.513
MET met proto-oncogene (hepatocyte growth factor receptor) 0.495
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.485
NCL nucleolin 0.481
BIRC2 baculoviral IAP repeat containing 2 0.470
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.465
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.458
S100A14 S100 calcium binding protein A14 0.448
GGTLC1 gamma-glutamyltransferase light chain 1 0.445
RXRA retinoid X receptor, alpha 0.429
APAF1 apoptotic peptidase activating factor 1 0.422
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.419
FASLG Fas ligand (TNF superfamily, member 6) 0.402
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.400
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.382
PYCARD PYD and CARD domain containing 0.381
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.376
HDAC2 histone deacetylase 2 0.373
FYN FYN oncogene related to SRC, FGR, YES 0.369
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.368
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.361
SOCS1 suppressor of cytokine signaling 1 0.361
BAK1 BCL2-antagonist/killer 1 0.332
SP1 Sp1 transcription factor 0.332
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.325
C4orf14 chromosome 4 open reading frame 14 0.305
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.302
GAS7 growth arrest-specific 7 0.291
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.291
GAST gastrin 0.289
SMAD2 SMAD family member 2 0.285
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.285
CREBBP CREB binding protein 0.277
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.272
PLAT plasminogen activator, tissue 0.269
VDAC2 voltage-dependent anion channel 2 0.268
KLK10 kallikrein-related peptidase 10 0.262
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.254
PML promyelocytic leukemia 0.251
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.251
SET SET nuclear oncogene 0.242
CDK2 cyclin-dependent kinase 2 0.239
KLK7 kallikrein-related peptidase 7 0.234
HCK hemopoietic cell kinase 0.234
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.224
SP100 SP100 nuclear antigen 0.213
SQSTM1 sequestosome 1 0.209
COL4A4 collagen, type IV, alpha 4 0.206
S100A11 S100 calcium binding protein A11 0.201
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.193
ESR1 estrogen receptor 1 0.191
VDAC1 voltage-dependent anion channel 1 0.186
PRSS2 protease, serine, 2 (trypsin 2) 0.185
BIK BCL2-interacting killer (apoptosis-inducing) 0.184
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.180
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.177
PIAS1 protein inhibitor of activated STAT, 1 0.176
PELP1 proline, glutamate and leucine rich protein 1 0.175
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.171
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.973
Tnf tumor necrosis factor 0.932
Cd44 CD44 antigen 0.918
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.917
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.849
Klk1b11 kallikrein 1-related peptidase b11 0.792
Klk1b5 kallikrein 1-related peptidase b5 0.783
Klk1b8 kallikrein 1-related peptidase b8 0.778
Bcl2 B-cell leukemia/lymphoma 2 0.721
Casp1 caspase 1 0.714
Lyz2 lysozyme 2 0.652
Fas Fas (TNF receptor superfamily member 6) 0.628
Lta lymphotoxin A 0.597
Skil SKI-like 0.562
Klk1b21 kallikrein 1-related peptidase b21 0.553
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.520
Kit kit oncogene 0.519
Klk1b4 kallikrein 1-related pepidase b4 0.497
Klk1b1 kallikrein 1-related peptidase b1 0.486
Ikzf1 IKAROS family zinc finger 1 0.439
Irf9 interferon regulatory factor 9 0.433
Klk1 kallikrein 1 0.430
Ptgs2 prostaglandin-endoperoxide synthase 2 0.417
Pycard PYD and CARD domain containing 0.406
Vhl von Hippel-Lindau tumor suppressor 0.400
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.372
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.340
Il1r1 interleukin 1 receptor, type I 0.316
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.305
Klk1b26 kallikrein 1-related petidase b26 0.290
Try5 trypsin 5 0.289
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.287
Rb1 retinoblastoma 1 0.276
Prss2 protease, serine, 2 0.270
Mcl1 myeloid cell leukemia sequence 1 0.269
Bax BCL2-associated X protein 0.261
Stat5a signal transducer and activator of transcription 5A 0.257
Ptprc protein tyrosine phosphatase, receptor type, C 0.255
Cela2a chymotrypsin-like elastase family, member 2A 0.242
Rps3 ribosomal protein S3 0.232
Hist1h1c histone cluster 1, H1c 0.230
Il10 interleukin 10 0.224
Stat5b signal transducer and activator of transcription 5B 0.212
Fndc7 fibronectin type III domain containing 7 0.209
Tff2 trefoil factor 2 (spasmolytic protein 1) 0.209
Ptpn2 protein tyrosine phosphatase, non-receptor type 2 0.206
Itih1 inter-alpha trypsin inhibitor, heavy chain 1 0.205
Klk1b9 kallikrein 1-related peptidase b9 0.204
Casp8 caspase 8 0.200
Klk1b24 kallikrein 1-related peptidase b24 0.195
5430421N21Rik RIKEN cDNA 5430421N21 gene 0.194
Tlr4 toll-like receptor 4 0.183
Ctrb1 chymotrypsinogen B1 0.182
Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.181
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.181
Rbl1 retinoblastoma-like 1 (p107) 0.181
Stat3 signal transducer and activator of transcription 3 0.178
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.172
Il2rg interleukin 2 receptor, gamma chain 0.170
Gbp5 guanylate binding protein 5 0.166
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.164
Cd247 CD247 antigen 0.155
Klk1b3 kallikrein 1-related peptidase b3 0.153
Fadd Fas (TNFRSF6)-associated via death domain 0.153
Spna1 spectrin alpha 1 0.151
Sycn syncollin 0.145
Il22 interleukin 22 0.143
Slit3 slit homolog 3 (Drosophila) 0.138
Wt1 Wilms tumor 1 homolog 0.135
Apc adenomatosis polyposis coli 0.134
F2 coagulation factor II 0.133
Ilk integrin linked kinase 0.130
Klk1b27 kallikrein 1-related peptidase b27 0.122
Hif1a hypoxia inducible factor 1, alpha subunit 0.121
Egfr epidermal growth factor receptor 0.120
Il1b interleukin 1 beta 0.120
Zg16 zymogen granule protein 16 0.120
Afm afamin 0.118
Klk1b16 kallikrein 1-related peptidase b16 0.116
Proc protein C 0.115
Jak2 Janus kinase 2 0.114
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.113
Socs1 suppressor of cytokine signaling 1 0.113
Ltb lymphotoxin B 0.112
Ncoa3 nuclear receptor coactivator 3 0.108
Aim2 absent in melanoma 2 0.103
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.102
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.101
Igh immunoglobulin heavy chain complex 0.096
Hbb-b1 hemoglobin, beta adult major chain 0.095
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.094
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.094
Emx1 empty spiracles homolog 1 (Drosophila) 0.094
Cuzd1 CUB and zona pellucida-like domains 1 0.093
Cxcr5 chemokine (C-X-C motif) receptor 5 0.093
Clps colipase, pancreatic 0.089
Hoxa13 homeobox A13 0.088
Dmbt1 deleted in malignant brain tumors 1 0.088
Lepr leptin receptor 0.086
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.081
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism