IMP
Process View
The network for 'aflatoxin metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
aflatoxin metabolic process
The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| serpinf2 | serine (or cysteine) peptidase inhibitor, clade F, member 2 | 0.143 | |
| upp2 | uridine phosphorylase 2 | 0.113 | |
| cyp51 | cytochrome P450, family 51 | 0.064 | |
| nr5a5 | nuclear receptor subfamily 5, group A, member 5 | 0.054 | |
| proc | protein C (inactivator of coagulation factors Va and VIIIa) | 0.052 | |
| sult1st3 | sulfotransferase family 1, cytosolic sulfotransferase 3 | 0.050 | |
| ahsg | alpha-2-HS-glycoprotein | 0.049 | |
| lipc | lipase, hepatic | 0.042 | |
| abp1 | amiloride binding protein 1 (amine oxidase (copper-containing)) | 0.037 | |
| slc34a2a | solute carrier family 34 (sodium phosphate), member 2a | 0.035 | |
| mep1a.1 | meprin A, alpha.1 | 0.033 | |
| cyp2aa1 | cytochrome P450, family 2, subfamily AA, polypeptide 1 | 0.030 | |
| chia.2 | chitinase, acidic.2 | 0.030 | |
| cyp4t8 | cytochrome P450, family 4, subfamily T, polypeptide 8 | 0.029 | |
| shbg | sex hormone binding globulin | 0.028 | |
| igfbp1b | insulin-like growth factor binding protein 1b | 0.027 | |
| LOC569770 | cytochrome c oxidase subunit 8B, mitochondrial-like | 0.024 | |
| srd5a2a | steroid-5-alpha-reductase, alpha polypeptide 2a | 0.023 | |
| map9 | microtubule-associated protein 9 | 0.023 | |
| angptl3 | angiopoietin-like 3 | 0.023 | |
| spata18 | spermatogenesis associated 18 | 0.022 | |
| cyp24a1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.022 | |
| shmt2 | serine hydroxymethyltransferase 2 (mitochondrial) | 0.022 | |
| ahr1a | aryl hydrocarbon receptor 1a | 0.021 | |
| irgq1 | immunity-related GTPase family, q1 | 0.021 | |
| agmo | alkylglycerol monooxygenase | 0.020 | |
| zgc:113516 | zgc:113516 | 0.020 | |
| zgc:64076 | zgc:64076 | 0.019 | |
| zgc:56326 | zgc:56326 | 0.018 | |
| cyp2k18 | cytochrome P450, family 2, subfamily K, polypeptide 18 | 0.017 | |
| pklr | pyruvate kinase, liver and RBC | 0.017 | |
| zgc:92406 | zgc:92406 | 0.017 | |
| cpne3 | copine III | 0.017 | |
| fabp10a | fatty acid binding protein 10a, liver basic | 0.017 | |
| hbl3 | hexose-binding lectin 3 | 0.017 | |
| star | steroidogenic acute regulatory protein | 0.017 | |
| ca9 | carbonic anhydrase IX | 0.016 | |
| hsd17b3 | hydroxysteroid (17-beta) dehydrogenase 3 | 0.016 | |
| slc8a4b | solute carrier family 8 (sodium/calcium exchanger), member 4b | 0.016 | |
| acad11 | acyl-Coenzyme A dehydrogenase family, member 11 | 0.016 | |
| zgc:112432 | zgc:112432 | 0.015 | |
| sat2 | spermidine/spermine N1-acetyltransferase family member 2 | 0.015 | |
| bcdo2l | beta-carotene 15, 15-dioxygenase 2, like | 0.014 | |
| cx32.3 | connexin 32.3 | 0.014 | |
| zgc:66484 | zgc:66484 | 0.014 | |
| mospd2 | motile sperm domain containing 2 | 0.014 | |
| oclna | occludin a | 0.014 | |
| zgc:56622 | zgc:56622 | 0.014 | |
| hprt1 | hypoxanthine phosphoribosyltransferase 1 | 0.014 | |
| hpx | hemopexin | 0.014 | |
| zgc:198195 | zgc:198195 | 0.013 | |
| zgc:153921 | zgc:153921 | 0.013 | |
| hnf4a | hepatocyte nuclear factor 4, alpha | 0.013 | |
| hsd17b1 | hydroxysteroid (17-beta) dehydrogenase 1 | 0.013 | |
| tbxas1 | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 0.013 | |
| vtg4 | vitellogenin 4 | 0.013 | |
| cyp2p6 | cytochrome P450, family 2, subfamily P, polypeptide 6 | 0.012 | |
| agt | angiotensinogen | 0.012 | |
| aqp12 | aquaporin 12 | 0.012 | |
| dio1 | deiodinase, iodothyronine, type I | 0.012 | |
| zgc:63774 | zgc:63774 | 0.012 | |
| ldhbb | lactate dehydrogenase Bb | 0.012 | |
| hprt1l | hypoxanthine phosphoribosyltransferase 1, like | 0.012 | |
| si:ch211-93f2.1 | si:ch211-93f2.1 | 0.011 | |
| im:7138629 | im:7138629 | 0.011 | |
| gcshb | glycine cleavage system protein H (aminomethyl carrier), b | 0.011 | |
| uox | urate oxidase | 0.011 | |
| irf9 | interferon regulatory factor 9 | 0.011 | |
| LOC559127 | similar to AWKS9372 | 0.011 | |
| LOC100005232 | Gig2-like protein DreD | 0.011 | |
| serpinb1l3 | serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3 | 0.011 | |
| acox3 | acyl-Coenzyme A oxidase 3, pristanoyl | 0.011 | |
| grk5 | G protein-coupled receptor kinase 5 | 0.011 | |
| ela2 | elastase 2 | 0.011 | |
| cpa1 | carboxypeptidase A1 (pancreatic) | 0.011 | |
| lonp2 | lon peptidase 2, peroxisomal | 0.010 | |
| sult3st1 | sulfotransferase family 3, cytosolic sulfotransferase 1 | 0.010 | |
| bbs7 | Bardet-Biedl syndrome 7 | 0.010 | |
| slc25a27 | solute carrier family 25, member 27 | 0.010 | |
| gstal | glutathione S-transferase, alpha-like | 0.010 | |
| adh8a | alcohol dehydrogenase 8a | 0.010 | |
| cldnc | claudin c | 0.010 | |
| cldn11b | claudin 11b | 0.010 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Gstm1 | glutathione S-transferase, mu 1 | 0.194 | |
| Gstt1 | glutathione S-transferase, theta 1 | 0.099 | |
| Cbr1 | carbonyl reductase 1 | 0.070 | |
| Selenbp1 | selenium binding protein 1 | 0.046 | |
| Prdx6 | peroxiredoxin 6 | 0.043 | |
| Gsto1 | glutathione S-transferase omega 1 | 0.034 | |
| Ces1d | carboxylesterase 1D | 0.031 | |
| Pgls | 6-phosphogluconolactonase | 0.027 | |
| Hsd3b7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 0.027 | |
| Cmbl | carboxymethylenebutenolidase-like (Pseudomonas) | 0.022 | |
| Cyb5 | cytochrome b-5 | 0.020 | |
| Tmem205 | transmembrane protein 205 | 0.017 | |
| Gstk1 | glutathione S-transferase kappa 1 | 0.015 | |
| Aox1 | aldehyde oxidase 1 | 0.013 | |
| BC004004 | cDNA sequence BC004004 | 0.012 | |
| Aldh1a1 | aldehyde dehydrogenase family 1, subfamily A1 | 0.011 | |
| Eci1 | enoyl-Coenzyme A delta isomerase 1 | 0.011 | |
| Chchd10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | 0.011 | |
| Adh1 | alcohol dehydrogenase 1 (class I) | 0.010 |