IMP

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Homo sapiens

31 genes annotated in human

protein k63 linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein k63 linked ubiquitination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein k63 linked ubiquitination" (in gray)

Name	Description	Probability	Func Analog Organism
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	1.000	Human
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	1.000	Human
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	1.000
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	1.000
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.999	Human
RNF11	ring finger protein 11	0.998
ZNRF1	zinc and ring finger 1	0.979
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.973	Human
ARIH2	ariadne homolog 2 (Drosophila)	0.962
BIRC3	baculoviral IAP repeat containing 3	0.941	Human
TRAF3	TNF receptor-associated factor 3	0.905	Human
RNF5	ring finger protein 5	0.877
DTX3L	deltex 3-like (Drosophila)	0.851
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.835	Human
TRAF6	TNF receptor-associated factor 6	0.800
TRAF2	TNF receptor-associated factor 2	0.670
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.661
TRIM39	tripartite motif containing 39	0.661	Human
BIRC2	baculoviral IAP repeat containing 2	0.605
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.594	Human
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.592
RNF168	ring finger protein 168	0.584
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.547
TRIM43	tripartite motif containing 43	0.500
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.474	Human
UBC	ubiquitin C	0.432
RNF111	ring finger protein 111	0.431
TRIM27	tripartite motif containing 27	0.412
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.373
XIAP	X-linked inhibitor of apoptosis	0.352	Human
FBXW11	F-box and WD repeat domain containing 11	0.352
TRAF1	TNF receptor-associated factor 1	0.349	Human
TRIM32	tripartite motif containing 32	0.301
CUL1	cullin 1	0.286
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.282
MARCH7	membrane-associated ring finger (C3HC4) 7	0.269
UBA1	ubiquitin-like modifier activating enzyme 1	0.269
ANKRD28	ankyrin repeat domain 28	0.263
MED15	mediator complex subunit 15	0.257
DZIP3	DAZ interacting protein 3, zinc finger	0.234
ZMYND11	zinc finger, MYND-type containing 11	0.223
ZRANB1	zinc finger, RAN-binding domain containing 1	0.215
ZNF746	zinc finger protein 746	0.181
DAXX	death-domain associated protein	0.174
RNF185	ring finger protein 185	0.164	Human
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.147
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.143
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.141
RIPK2	receptor-interacting serine-threonine kinase 2	0.136
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.128
UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.122
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.116	Human Mouse
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.116	Human
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.107
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.107
AMFR	autocrine motility factor receptor	0.103
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.102
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.099
CD40	CD40 molecule, TNF receptor superfamily member 5	0.099
RNF10	ring finger protein 10	0.097
RHOA	ras homolog gene family, member A	0.087
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.085
MARCH5	membrane-associated ring finger (C3HC4) 5	0.085
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.080
RNF2	ring finger protein 2	0.071
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.070
FBXL15	F-box and leucine-rich repeat protein 15	0.067
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.066
TRIM5	tripartite motif containing 5	0.064
ZNF263	zinc finger protein 263	0.063
TRADD	TNFRSF1A-associated via death domain	0.061
SKP1	S-phase kinase-associated protein 1	0.060
RNF14	ring finger protein 14	0.060
ING2	inhibitor of growth family, member 2	0.058
RANGAP1	Ran GTPase activating protein 1	0.057
ANKRD13A	ankyrin repeat domain 13A	0.056
RNF114	ring finger protein 114	0.054
RNF126	ring finger protein 126	0.051	Mouse
RNF4	ring finger protein 4	0.047	Rat
BFAR	bifunctional apoptosis regulator	0.047
PML	promyelocytic leukemia	0.045
TRIM26	tripartite motif containing 26	0.043
USP15	ubiquitin specific peptidase 15	0.043
NUMBL	numb homolog (Drosophila)-like	0.042
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.042
HN1	hematological and neurological expressed 1	0.041
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.041
RNF130	ring finger protein 130	0.039
UBE3A	ubiquitin protein ligase E3A	0.037
RYBP	RING1 and YY1 binding protein	0.036
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.036	Human Rat
FAF2	Fas associated factor family member 2	0.036
BTRC	beta-transducin repeat containing	0.036
UBOX5	U-box domain containing 5	0.035
RLIM	ring finger protein, LIM domain interacting	0.035
MID1	midline 1 (Opitz/BBB syndrome)	0.035
TP53BP1	tumor protein p53 binding protein 1	0.035
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.035	Human
ZNF473	zinc finger protein 473	0.034
RNPS1	RNA binding protein S1, serine-rich domain	0.034
TRIM8	tripartite motif containing 8	0.034
RAD23B	RAD23 homolog B (S. cerevisiae)	0.033
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.032
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.032
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.032
BIRC8	baculoviral IAP repeat containing 8	0.030	Human
SIAH1	seven in absentia homolog 1 (Drosophila)	0.030
ATXN3	ataxin 3	0.030
IRF9	interferon regulatory factor 9	0.029
MDC1	mediator of DNA-damage checkpoint 1	0.029
ZFAND5	zinc finger, AN1-type domain 5	0.028
POLH	polymerase (DNA directed), eta	0.028
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.028
CYLD	cylindromatosis (turban tumor syndrome)	0.027
RNF38	ring finger protein 38	0.026
GSK3B	glycogen synthase kinase 3 beta	0.024
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.024
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.024
CHFR	checkpoint with forkhead and ring finger domains	0.023	Human
RIPK3	receptor-interacting serine-threonine kinase 3	0.023
RNF26	ring finger protein 26	0.023
BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	0.023
SAMD9	sterile alpha motif domain containing 9	0.023
ZBTB8A	zinc finger and BTB domain containing 8A	0.022
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.022
TUBB2C	tubulin, beta 2C	0.022
SP100	SP100 nuclear antigen	0.022
AUP1	ancient ubiquitous protein 1	0.022
ZFYVE9	zinc finger, FYVE domain containing 9	0.022
AARSD1	alanyl-tRNA synthetase domain containing 1	0.021
DTX3	deltex homolog 3 (Drosophila)	0.021
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.021
ZNF420	zinc finger protein 420	0.021
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.021
RNF181	ring finger protein 181	0.020
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.020
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.020
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.020
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.019
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.019
UBXN7	UBX domain protein 7	0.019
USP2	ubiquitin specific peptidase 2	0.019
UBXN1	UBX domain protein 1	0.019
TRAF4	TNF receptor-associated factor 4	0.019	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.019
UBASH3B	ubiquitin associated and SH3 domain containing B	0.019
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.019
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.018
IFIH1	interferon induced with helicase C domain 1	0.018
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.018
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.018
TRIM25	tripartite motif containing 25	0.017
RAD18	RAD18 homolog (S. cerevisiae)	0.017
RAD23A	RAD23 homolog A (S. cerevisiae)	0.017
RNF31	ring finger protein 31	0.016
VCP	valosin containing protein	0.016
PSME4	proteasome (prosome, macropain) activator subunit 4	0.016
TRIM21	tripartite motif containing 21	0.016	Human
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.016
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.016
PAIP2	poly(A) binding protein interacting protein 2	0.016
WNK1	WNK lysine deficient protein kinase 1	0.016
TUBA1B	tubulin, alpha 1b	0.015
NBN	nibrin	0.015
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.015
CAB39	calcium binding protein 39	0.015
SENP3	SUMO1/sentrin/SMT3 specific peptidase 3	0.015
ANKRD17	ankyrin repeat domain 17	0.015
CSNK1D	casein kinase 1, delta	0.015
PIAS3	protein inhibitor of activated STAT, 3	0.014
TRIM35	tripartite motif containing 35	0.014
TRIM41	tripartite motif containing 41	0.014	Human
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.014
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.014
SMAD1	SMAD family member 1	0.013
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.013
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.013
PRCC	papillary renal cell carcinoma (translocation-associated)	0.013
PRKCA	protein kinase C, alpha	0.013
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.013
OXSR1	oxidative-stress responsive 1	0.013
FBXO7	F-box protein 7	0.013
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.013
DIABLO	diablo, IAP-binding mitochondrial protein	0.013
PINK1	PTEN induced putative kinase 1	0.013
RNF166	ring finger protein 166	0.013
USP9X	ubiquitin specific peptidase 9, X-linked	0.012
RNF213	ring finger protein 213	0.012
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.012
TUBA1C	tubulin, alpha 1c	0.012
ANAPC11	anaphase promoting complex subunit 11	0.012
NMI	N-myc (and STAT) interactor	0.012
GBP3	guanylate binding protein 3	0.012
MEX3B	mex-3 homolog B (C. elegans)	0.012
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.012
RING1	ring finger protein 1	0.012
RANBP9	RAN binding protein 9	0.012
KCMF1	potassium channel modulatory factor 1	0.012
POU5F1	POU class 5 homeobox 1	0.011
PLK1	polo-like kinase 1	0.011
CHD4	chromodomain helicase DNA binding protein 4	0.011
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.011
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.011
PDCD2	programmed cell death 2	0.011
TRAF5	TNF receptor-associated factor 5	0.011	Human
KLF5	Kruppel-like factor 5 (intestinal)	0.011
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.011
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.011
UBB	ubiquitin B	0.011
FBXW2	F-box and WD repeat domain containing 2	0.011
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.011
PCGF2	polycomb group ring finger 2	0.011
POLR3F	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa	0.010
RNF115	ring finger protein 115	0.010	Mouse
CDYL	chromodomain protein, Y-like	0.010
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.010
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.010
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.010
ABHD16A	abhydrolase domain containing 16A	0.010
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.010
PRPS1	phosphoribosyl pyrophosphate synthetase 1	0.010
ARL15	ADP-ribosylation factor-like 15	0.010