IMP
Process View
activation induced cell death of t cells
A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "activation induced cell death of t cells"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 1.000 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.952 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.892 | Mouse | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.890 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.855 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.727 | ||
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.706 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.675 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.340 | ||
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.236 | ||
| NOXA1 | NADPH oxidase activator 1 | 0.232 | ||
| NCF1 | neutrophil cytosolic factor 1 | 0.201 | ||
| PRKCZ | protein kinase C, zeta | 0.165 | Human | |
| PARD6B | par-6 partitioning defective 6 homolog beta (C. elegans) | 0.156 | ||
| NUMB | numb homolog (Drosophila) | 0.144 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.142 | Mouse | |
| RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | 0.133 | ||
| PARD6A | par-6 partitioning defective 6 homolog alpha (C. elegans) | 0.125 | ||
| RPS4X | ribosomal protein S4, X-linked | 0.105 | ||
| CDC37 | cell division cycle 37 homolog (S. cerevisiae) | 0.085 | ||
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.078 | ||
| RPS3 | ribosomal protein S3 | 0.075 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.074 | ||
| TRAF1 | TNF receptor-associated factor 1 | 0.071 | ||
| RPL5 | ribosomal protein L5 | 0.066 | ||
| PARD6G | par-6 partitioning defective 6 homolog gamma (C. elegans) | 0.065 | ||
| PICK1 | protein interacting with PRKCA 1 | 0.061 | ||
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.048 | ||
| ZNF71 | zinc finger protein 71 | 0.046 | ||
| RPS3A | ribosomal protein S3A | 0.046 | ||
| LRRK2 | leucine-rich repeat kinase 2 | 0.046 | ||
| DCTN1 | dynactin 1 | 0.044 | ||
| PARD3 | par-3 partitioning defective 3 homolog (C. elegans) | 0.043 | ||
| CCDC115 | coiled-coil domain containing 115 | 0.043 | ||
| MAPT | microtubule-associated protein tau | 0.038 | ||
| TRIM9 | tripartite motif containing 9 | 0.036 | ||
| TRADD | TNFRSF1A-associated via death domain | 0.036 | ||
| PPP1R9B | protein phosphatase 1, regulatory (inhibitor) subunit 9B | 0.036 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.035 | ||
| BID | BH3 interacting domain death agonist | 0.032 | ||
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.031 | ||
| CDCP1 | CUB domain containing protein 1 | 0.030 | ||
| HPCAL4 | hippocalcin like 4 | 0.030 | ||
| VHL | von Hippel-Lindau tumor suppressor | 0.028 | ||
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.026 | ||
| MPRIP | myosin phosphatase Rho interacting protein | 0.025 | ||
| ALDOA | aldolase A, fructose-bisphosphate | 0.024 | ||
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) | 0.024 | ||
| RPS8 | ribosomal protein S8 | 0.023 | ||
| SH3RF1 | SH3 domain containing ring finger 1 | 0.023 | ||
| PRKCB | protein kinase C, beta | 0.022 | ||
| RPL4 | ribosomal protein L4 | 0.019 | ||
| TSC22D1 | TSC22 domain family, member 1 | 0.019 | ||
| RARA | retinoic acid receptor, alpha | 0.018 | ||
| RPS16 | ribosomal protein S16 | 0.018 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.018 | ||
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 0.018 | ||
| VIM | vimentin | 0.017 | ||
| RPL6 | ribosomal protein L6 | 0.017 | ||
| STK4 | serine/threonine kinase 4 | 0.016 | ||
| CYBA | cytochrome b-245, alpha polypeptide | 0.015 | ||
| RPS24 | ribosomal protein S24 | 0.015 | ||
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | 0.015 | ||
| RPL7 | ribosomal protein L7 | 0.015 | ||
| TPM3 | tropomyosin 3 | 0.015 | ||
| RPL14 | ribosomal protein L14 | 0.015 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.015 | ||
| PEBP4 | phosphatidylethanolamine-binding protein 4 | 0.014 | ||
| PTK2B | PTK2B protein tyrosine kinase 2 beta | 0.013 | ||
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.013 | ||
| FAM129A | family with sequence similarity 129, member A | 0.012 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.012 | ||
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.012 | ||
| PPP2R4 | protein phosphatase 2A activator, regulatory subunit 4 | 0.011 | ||
| ILK | integrin-linked kinase | 0.011 | ||
| MALT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | 0.011 | ||
| BAD | BCL2-associated agonist of cell death | 0.011 | ||
| NMT2 | N-myristoyltransferase 2 | 0.011 | ||
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 0.011 | Human | |
| MYO1D | myosin ID | 0.011 | ||
| FABP4 | fatty acid binding protein 4, adipocyte | 0.011 | ||
| RPL17 | ribosomal protein L17 | 0.011 | ||
| WWC1 | WW and C2 domain containing 1 | 0.010 | ||
| BIRC3 | baculoviral IAP repeat containing 3 | 0.010 | ||
| LLGL1 | lethal giant larvae homolog 1 (Drosophila) | 0.010 | ||
| SAMD4B | sterile alpha motif domain containing 4B | 0.010 | ||
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.010 |