IMP
Process View
trail activated apoptotic signaling pathway
An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
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Click on a gene's description to view its network relationships with genes known to be involved in "trail activated apoptotic signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 1.000 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 1.000 | Human | |
| FADD | Fas (TNFRSF6)-associated via death domain | 1.000 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 1.000 | Human | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 1.000 | Human | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 1.000 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.999 | Human | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.998 | ||
| XIAP | X-linked inhibitor of apoptosis | 0.998 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.994 | ||
| APAF1 | apoptotic peptidase activating factor 1 | 0.988 | ||
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.939 | Human | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.937 | ||
| TRADD | TNFRSF1A-associated via death domain | 0.919 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.842 | ||
| BIRC2 | baculoviral IAP repeat containing 2 | 0.796 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.788 | Human | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.780 | Human | |
| TRAF1 | TNF receptor-associated factor 1 | 0.765 | ||
| BIRC3 | baculoviral IAP repeat containing 3 | 0.608 | ||
| SOD1 | superoxide dismutase 1, soluble | 0.553 | ||
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.392 | ||
| TRAF2 | TNF receptor-associated factor 2 | 0.303 | ||
| FAM101B | family with sequence similarity 101, member B | 0.173 | ||
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.165 | ||
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.097 | Human | |
| CASP8AP2 | caspase 8 associated protein 2 | 0.092 | ||
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.075 | ||
| BID | BH3 interacting domain death agonist | 0.075 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.062 | ||
| TNF | tumor necrosis factor | 0.052 | ||
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.050 | ||
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.049 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.035 | ||
| CTSS | cathepsin S | 0.035 | ||
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.030 | ||
| NUCB2 | nucleobindin 2 | 0.029 | ||
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.026 | ||
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.020 | ||
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.019 | ||
| SP100 | SP100 nuclear antigen | 0.019 | ||
| GLRX | glutaredoxin (thioltransferase) | 0.019 | ||
| IL18 | interleukin 18 (interferon-gamma-inducing factor) | 0.019 | ||
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.017 | ||
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 0.016 | ||
| CARD16 | caspase recruitment domain family, member 16 | 0.016 | ||
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.015 | ||
| MYH9 | myosin, heavy chain 9, non-muscle | 0.015 | ||
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.014 | ||
| MAGED1 | melanoma antigen family D, 1 | 0.013 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.012 | ||
| SAMD9 | sterile alpha motif domain containing 9 | 0.011 | ||
| CASP6 | caspase 6, apoptosis-related cysteine peptidase | 0.010 | Human | |
| NOTCH1 | notch 1 | 0.010 |