IMP

Process View

Homo sapiens

1 genes annotated in human

ripoptosome assembly

The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ripoptosome assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ripoptosome assembly" (in gray)

Name	Description	Probability	Func Analog Organism
BIRC3	baculoviral IAP repeat containing 3	0.986
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.838
BIRC2	baculoviral IAP repeat containing 2	0.723
RIPK3	receptor-interacting serine-threonine kinase 3	0.507	Human
TANK	TRAF family member-associated NFKB activator	0.505
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.488
TRAF1	TNF receptor-associated factor 1	0.342
RIPK2	receptor-interacting serine-threonine kinase 2	0.224	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.186
TRAF3	TNF receptor-associated factor 3	0.117
TRAF2	TNF receptor-associated factor 2	0.113
HDAC6	histone deacetylase 6	0.050
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.038
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.035
TRAF6	TNF receptor-associated factor 6	0.024
TBK1	TANK-binding kinase 1	0.023
TUBA1A	tubulin, alpha 1a	0.022
BBS10	Bardet-Biedl syndrome 10	0.022
CYLD	cylindromatosis (turban tumor syndrome)	0.018	Mouse
TRADD	TNFRSF1A-associated via death domain	0.017
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.016
TRIM38	tripartite motif containing 38	0.014
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.014
RIPK4	receptor-interacting serine-threonine kinase 4	0.011	Human
USP15	ubiquitin specific peptidase 15	0.011
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.011