Homo sapiens

201 known processes

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

(Aliases: MAD-3,NFKBI,IKBA)

NFKBIA biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
amide biosynthetic process GO:0043604 15 1.000
Fly
regulation of i kappab kinase nf kappab signaling GO:0043122 162 1.000
response to biotic stimulus GO:0009607 276 1.000
Human Zebrafish Mouse Fly
i kappab kinase nf kappab signaling GO:0007249 166 1.000
negative regulation of interleukin 8 biosynthetic process GO:0045415 3 0.999
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.999
positive regulation of humoral immune response GO:0002922 3 0.999
Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.999
positive regulation of antimicrobial humoral response GO:0002760 1 0.998
Fly
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.998
Fly
cellular response to biotic stimulus GO:0071216 71 0.998
Mouse
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.997
regulation of cytokine production GO:0001817 232 0.997
Human
positive regulation of defense response GO:0031349 87 0.997
Mouse Fly
defense response GO:0006952 315 0.997
Mouse Fly
response to virus GO:0009615 126 0.995
Human Zebrafish
cytokine production GO:0001816 247 0.995
Human
reactive nitrogen species metabolic process GO:2001057 3 0.995
regulation of defense response GO:0031347 154 0.994
Mouse Fly
response to external biotic stimulus GO:0043207 261 0.994
Human Zebrafish Mouse Fly
regulation of antimicrobial humoral response GO:0002759 1 0.994
Fly
negative regulation of cell death GO:0060548 345 0.994
Human
reactive oxygen species biosynthetic process GO:1903409 4 0.994
regulation of protein localization to nucleus GO:1900180 85 0.994
intracellular protein transport GO:0006886 270 0.993
regulation of response to external stimulus GO:0032101 222 0.992
Fly
response to lipopolysaccharide GO:0032496 70 0.990
Mouse
negative regulation of programmed cell death GO:0043069 321 0.990
Human
nf kappab import into nucleus GO:0042348 22 0.990
regulation of multi organism process GO:0043900 157 0.989
Fly
cytokine mediated signaling pathway GO:0019221 109 0.989
apoptotic signaling pathway GO:0097190 268 0.989
Human
response to oxygen containing compound GO:1901700 369 0.988
Mouse
antimicrobial humoral response GO:0019730 26 0.988
Fly
single organism nuclear import GO:1902593 104 0.986
positive regulation of immune system process GO:0002684 283 0.985
Mouse Fly
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.984
regulation of immune response GO:0050776 201 0.984
Mouse Fly
regulation of immune effector process GO:0002697 91 0.984
Fly
activation of innate immune response GO:0002218 55 0.984
Mouse
positive regulation of immune response GO:0050778 159 0.984
Mouse Fly
cellular response to oxygen containing compound GO:1901701 276 0.984
Mouse
response to bacterium GO:0009617 144 0.984
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.983
Human Mouse
protein localization to nucleus GO:0034504 136 0.982
negative regulation of cell differentiation GO:0045596 171 0.982
regulation of interleukin 8 production GO:0032677 49 0.982
Human
negative regulation of cytokine production GO:0001818 82 0.980
Human
immune response GO:0006955 307 0.979
Mouse Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.977
cytokine biosynthetic process GO:0042089 37 0.974
Human
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.970
Mouse
vitamin d metabolic process GO:0042359 10 0.970
response to abiotic stimulus GO:0009628 336 0.969
Human
intrinsic apoptotic signaling pathway GO:0097193 127 0.968
Human
production of molecular mediator of immune response GO:0002440 37 0.963
Fly
establishment of protein localization to organelle GO:0072594 172 0.963
negative regulation of interleukin 8 production GO:0032717 12 0.962
Human
negative regulation of protein transport GO:0051224 75 0.962
positive regulation of innate immune response GO:0045089 79 0.961
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.961
positive regulation of response to external stimulus GO:0032103 88 0.959
Fly
negative regulation of protein metabolic process GO:0051248 391 0.958
Human
peptide metabolic process GO:0006518 51 0.956
Fly
defense response to fungus GO:0050832 4 0.954
Fly
defense response to virus GO:0051607 71 0.953
fat soluble vitamin metabolic process GO:0006775 19 0.952
positive regulation of cytokine production GO:0001819 167 0.951
pattern recognition receptor signaling pathway GO:0002221 48 0.950
Mouse
cellular response to molecule of bacterial origin GO:0071219 62 0.945
Mouse
regulation of interleukin 8 biosynthetic process GO:0045414 11 0.945
Human
regulation of protein import into nucleus GO:0042306 78 0.941
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.940
Human
response to other organism GO:0051707 261 0.939
Human Zebrafish Mouse Fly
regulation of intracellular protein transport GO:0033157 123 0.939
negative regulation of lipid storage GO:0010888 11 0.936
cellular response to lipopolysaccharide GO:0071222 57 0.935
Mouse
antifungal humoral response GO:0019732 2 0.934
Fly
response to molecule of bacterial origin GO:0002237 82 0.934
Mouse
regulation of response to biotic stimulus GO:0002831 55 0.934
Fly
negative regulation of developmental process GO:0051093 247 0.933
response to fungus GO:0009620 4 0.933
Fly
regulation of vitamin metabolic process GO:0030656 9 0.929
nuclear transport GO:0051169 179 0.929
reactive oxygen species metabolic process GO:0072593 75 0.927
regulation of transcription factor import into nucleus GO:0042990 39 0.917
innate immune response GO:0045087 178 0.915
Mouse
regulation of lipid metabolic process GO:0019216 96 0.913
amide transport GO:0042886 76 0.911
protein localization to organelle GO:0033365 280 0.908
interleukin 8 production GO:0032637 51 0.908
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.903
Human
female gamete generation GO:0007292 2 0.903
Fly
regulation of macrophage derived foam cell differentiation GO:0010743 14 0.901
positive regulation of hyaluronan biosynthetic process GO:1900127 3 0.895
negative regulation of apoptotic process GO:0043066 316 0.894
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.889
Mouse
response to uv GO:0009411 73 0.887
Human
response to cytokine GO:0034097 232 0.886
negative regulation of vitamin metabolic process GO:0046137 6 0.886
protein import GO:0017038 130 0.885
humoral immune response GO:0006959 49 0.884
Fly
positive regulation of mirna metabolic process GO:2000630 4 0.884
response to radiation GO:0009314 151 0.878
Human
defense response to bacterium GO:0042742 63 0.864
t helper cell differentiation GO:0042093 4 0.864
posttranscriptional regulation of gene expression GO:0010608 213 0.862
Human
cellular response to lipid GO:0071396 127 0.858
Mouse
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.852
negative regulation of protein import into nucleus GO:0042308 30 0.848
cellular amide metabolic process GO:0043603 69 0.840
Fly
regulation of defense response to bacterium GO:1900424 2 0.833
lipid metabolic process GO:0006629 381 0.833
cytoplasmic transport GO:0016482 379 0.821
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.821
response to reactive oxygen species GO:0000302 61 0.820
nitrogen compound transport GO:0071705 191 0.817
regulation of cell differentiation GO:0045595 393 0.816
defense response to other organism GO:0098542 129 0.811
Fly
regulation of humoral immune response GO:0002920 11 0.810
Fly
organonitrogen compound biosynthetic process GO:1901566 200 0.809
Fly
negative regulation of protein localization to nucleus GO:1900181 34 0.807
cellular response to nitrogen compound GO:1901699 144 0.807
regulation of cytokine biosynthetic process GO:0042035 35 0.806
Human
regulation of defense response to virus by host GO:0050691 22 0.798
cellular response to dna damage stimulus GO:0006974 379 0.798
Human Fly
immune effector process GO:0002252 159 0.798
Fly
regulation of peptide transport GO:0090087 62 0.797
protein targeting to nucleus GO:0044744 104 0.790
negative regulation of endothelial cell apoptotic process GO:2000352 16 0.780
steroid metabolic process GO:0008202 94 0.779
regulation of nucleocytoplasmic transport GO:0046822 98 0.777
cellular response to organic cyclic compound GO:0071407 127 0.776
myeloid dendritic cell differentiation GO:0043011 3 0.770
response to lipid GO:0033993 206 0.757
Mouse
peptide transport GO:0015833 74 0.756
negative regulation of intracellular signal transduction GO:1902532 183 0.755
positive regulation of immune effector process GO:0002699 40 0.755
Fly
positive regulation of cholesterol efflux GO:0010875 8 0.753
response to light stimulus GO:0009416 87 0.752
Human
positive regulation of defense response to bacterium GO:1900426 1 0.750
regulation of nitric oxide biosynthetic process GO:0045428 17 0.750
positive regulation of defense response to virus by host GO:0002230 14 0.748
regulation of protein localization GO:0032880 296 0.748
antibacterial humoral response GO:0019731 24 0.745
regulation of nf kappab import into nucleus GO:0042345 22 0.727
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.708
Mouse
nervous system development GO:0007399 293 0.706
Fly
sterol transport GO:0015918 39 0.701
nucleocytoplasmic transport GO:0006913 176 0.700
oogenesis GO:0048477 2 0.687
Fly
innate immune response activating signal transduction GO:0002758 48 0.680
Mouse
response to inorganic substance GO:0010035 127 0.676
negative regulation of lipid biosynthetic process GO:0051055 22 0.662
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.655
cytokine metabolic process GO:0042107 38 0.651
Human
vitamin metabolic process GO:0006766 26 0.651
cell development GO:0048468 328 0.635
Fly
nuclear import GO:0051170 106 0.624
nitric oxide biosynthetic process GO:0006809 20 0.621
regulation of cytoplasmic transport GO:1903649 149 0.620
cellular response to oxidative stress GO:0034599 85 0.618
cholesterol transport GO:0030301 39 0.607
carbohydrate metabolic process GO:0005975 207 0.605
signal transduction in response to dna damage GO:0042770 57 0.604
Human
regulation of canonical wnt signaling pathway GO:0060828 88 0.601
maintenance of protein location in cell GO:0032507 56 0.599
regulation of intracellular transport GO:0032386 195 0.599
transcription factor import into nucleus GO:0042991 40 0.592
regulation of translation GO:0006417 89 0.590
Human
positive regulation of multi organism process GO:0043902 56 0.586
Fly
regulation of inflammatory response GO:0050727 46 0.585
chronic inflammatory response GO:0002544 2 0.584
negative regulation of vitamin d biosynthetic process GO:0010957 5 0.578
alpha beta t cell differentiation GO:0046632 7 0.574
regulation of cd40 signaling pathway GO:2000348 3 0.573
negative regulation of transport GO:0051051 176 0.572
protein import into nucleus GO:0006606 104 0.571
regulation of apoptotic signaling pathway GO:2001233 175 0.568
cellular response to peptide GO:1901653 59 0.564
regulation of lipid transport GO:0032368 44 0.560
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.557
cellular response to organonitrogen compound GO:0071417 124 0.553
inflammatory response GO:0006954 79 0.549
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.545
canonical wnt signaling pathway GO:0060070 116 0.539
single organism cellular localization GO:1902580 332 0.536
type 2 immune response GO:0042092 6 0.536
regulation of mapk cascade GO:0043408 262 0.534
cellular response to interleukin 1 GO:0071347 35 0.534
negative regulation of apoptotic signaling pathway GO:2001234 97 0.531
response to organic cyclic compound GO:0014070 204 0.530
Mouse
vesicle mediated transport GO:0016192 371 0.519
Fly
multicellular organismal aging GO:0010259 3 0.512
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.504
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.496
lipid transport GO:0006869 90 0.488
vitamin biosynthetic process GO:0009110 11 0.487
maintenance of location in cell GO:0051651 62 0.484
lipid localization GO:0010876 106 0.480
regulation of innate immune response GO:0045088 97 0.470
Mouse
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 5 0.464
Mouse
protein ubiquitination GO:0016567 314 0.464
lymphocyte mediated immunity GO:0002449 48 0.462
positive regulation of response to biotic stimulus GO:0002833 18 0.458
Fly
cell activation GO:0001775 213 0.454
regulation of sterol transport GO:0032371 21 0.443
negative regulation of oxidoreductase activity GO:0051354 17 0.442
tumor necrosis factor production GO:0032640 43 0.441
regulation of production of molecular mediator of immune response GO:0002700 25 0.436
Fly
cellular response to reactive oxygen species GO:0034614 50 0.428
cellular response to abiotic stimulus GO:0071214 117 0.427
jak stat cascade GO:0007259 46 0.427
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.421
positive regulation of wnt signaling pathway GO:0030177 54 0.420
fat soluble vitamin biosynthetic process GO:0042362 11 0.420
regulation of protein transport GO:0051223 213 0.418
leukocyte activation GO:0045321 164 0.418
negative regulation of intracellular transport GO:0032387 60 0.410
small molecule biosynthetic process GO:0044283 157 0.408
negative regulation of intracellular protein transport GO:0090317 42 0.407
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.396
regulation of reactive oxygen species metabolic process GO:2000377 41 0.388
regulation of cholesterol efflux GO:0010874 11 0.387
interleukin 12 biosynthetic process GO:0042090 1 0.385
negative regulation of interleukin 12 production GO:0032695 6 0.384
negative regulation of calcidiol 1 monooxygenase activity GO:0010956 3 0.375
cellular response to nicotine GO:0071316 4 0.365
modification dependent macromolecule catabolic process GO:0043632 212 0.363
immune system development GO:0002520 195 0.362
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.355
regulation of defense response to virus GO:0050688 33 0.354
positive regulation of mapk cascade GO:0043410 190 0.351
lipid biosynthetic process GO:0008610 177 0.342
response to oxidative stress GO:0006979 121 0.337
cellular response to endogenous stimulus GO:0071495 336 0.322
organic hydroxy compound biosynthetic process GO:1901617 71 0.315
cell activation involved in immune response GO:0002263 30 0.305
response to nitrogen compound GO:1901698 184 0.304
Mouse
cellular macromolecule catabolic process GO:0044265 380 0.303
endothelial cell apoptotic process GO:0072577 26 0.303
cellular response to hydrogen peroxide GO:0070301 37 0.300
negative regulation of cytoplasmic transport GO:1903650 46 0.298
blood vessel development GO:0001568 172 0.298
positive regulation of sterol transport GO:0032373 10 0.289
interleukin 8 biosynthetic process GO:0042228 12 0.283
Human
translation GO:0006412 132 0.283
Human
post embryonic development GO:0009791 2 0.282
extrinsic apoptotic signaling pathway GO:0097191 119 0.280
serine phosphorylation of stat protein GO:0042501 4 0.275
lymphocyte activation GO:0046649 133 0.266
protein catabolic process GO:0030163 325 0.263
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.262
cellular response to mechanical stimulus GO:0071260 39 0.256
response to peptide GO:1901652 65 0.256
Mouse
carbohydrate biosynthetic process GO:0016051 42 0.253
regulation of protein targeting GO:1903533 91 0.252
response to hormone GO:0009725 175 0.249
negative regulation of catalytic activity GO:0043086 335 0.247
regulation of kinase activity GO:0043549 314 0.242
cytoplasmic sequestering of nf kappab GO:0007253 7 0.242
osteoclast differentiation GO:0030316 21 0.237
myeloid cell differentiation GO:0030099 117 0.234
Mouse
activation of immune response GO:0002253 114 0.234
Mouse
regulation of lipid biosynthetic process GO:0046890 47 0.227
response to mechanical stimulus GO:0009612 51 0.225
nik nf kappab signaling GO:0038061 12 0.222
endocytosis GO:0006897 159 0.220
Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.219
aminoglycan metabolic process GO:0006022 39 0.219
immune response activating signal transduction GO:0002757 90 0.217
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.217
Human
protein k48 linked ubiquitination GO:0070936 38 0.214
cellular component morphogenesis GO:0032989 314 0.212
Fly
response to organonitrogen compound GO:0010243 156 0.209
Mouse
cd40 signaling pathway GO:0023035 3 0.209
interspecies interaction between organisms GO:0044419 156 0.209
negative regulation of transcription factor import into nucleus GO:0042992 17 0.207
regulation of cellular amide metabolic process GO:0034248 9 0.205
Fly
cellular response to cytokine stimulus GO:0071345 181 0.204
regulation of mirna metabolic process GO:2000628 5 0.203
wnt signaling pathway GO:0016055 156 0.200
positive regulation of sodium ion transport GO:0010765 14 0.200
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.198
Human
negative regulation of cytokine biosynthetic process GO:0042036 11 0.195
Human
spleen development GO:0048536 1 0.193
reproductive process GO:0022414 106 0.189
Fly
dorsal ventral axis specification GO:0009950 7 0.186
Fly
cellular response to hormone stimulus GO:0032870 125 0.185
regulation of establishment of protein localization GO:0070201 242 0.184
single organism carbohydrate metabolic process GO:0044723 193 0.183
mitochondrion organization GO:0007005 156 0.183
cytoplasmic sequestering of protein GO:0051220 12 0.183
regulation of wnt signaling pathway GO:0030111 123 0.180
cellular response to tumor necrosis factor GO:0071356 63 0.179
mucopolysaccharide metabolic process GO:1903510 27 0.179
carbohydrate derivative biosynthetic process GO:1901137 207 0.177
stem cell division GO:0017145 2 0.177
regulation of stress activated mapk cascade GO:0032872 84 0.175
positive regulation of catabolic process GO:0009896 310 0.169
response to tumor necrosis factor GO:0034612 76 0.166
negative regulation of response to external stimulus GO:0032102 83 0.166
leukocyte mediated immunity GO:0002443 59 0.165
peripheral nervous system development GO:0007422 2 0.164
regulation of steroid biosynthetic process GO:0050810 23 0.164
modification dependent protein catabolic process GO:0019941 209 0.161
cellular metal ion homeostasis GO:0006875 146 0.155
protein import into nucleus translocation GO:0000060 22 0.155
Human Mouse
immune response regulating signaling pathway GO:0002764 97 0.154
Mouse
negative regulation of cell proliferation GO:0008285 228 0.153
negative regulation of alcohol biosynthetic process GO:1902931 13 0.153
cell adhesion GO:0007155 325 0.147
dorsal ventral pattern formation GO:0009953 15 0.147
Fly
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.146
response to nicotine GO:0035094 12 0.146
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.145
negative regulation of multi organism process GO:0043901 92 0.142
protein complex localization GO:0031503 31 0.140
regulation of vitamin d biosynthetic process GO:0060556 8 0.139
regulation of cell cycle process GO:0010564 266 0.139
regulation of tumor necrosis factor production GO:0032680 43 0.139
response to uv c GO:0010225 7 0.137
Human
steroid biosynthetic process GO:0006694 46 0.137
multicellular organismal reproductive process GO:0048609 40 0.136
Fly
protein processing GO:0016485 226 0.136
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.136
regulation of endothelial cell apoptotic process GO:2000351 24 0.134
positive regulation of protein kinase activity GO:0045860 190 0.134
hemopoiesis GO:0030097 180 0.132
Mouse
proteasomal protein catabolic process GO:0010498 176 0.132
apoptotic mitochondrial changes GO:0008637 57 0.132
response to metal ion GO:0010038 84 0.132
negative regulation of neuron apoptotic process GO:0043524 23 0.131
cellular response to alkaloid GO:0071312 11 0.129
positive regulation of hemoglobin biosynthetic process GO:0046985 1 0.129
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.128
peptide biosynthetic process GO:0043043 8 0.128
Fly
regulation of toll like receptor 3 signaling pathway GO:0034139 2 0.128
single organism reproductive process GO:0044702 98 0.127
Fly
response to wounding GO:0009611 168 0.126
leukocyte differentiation GO:0002521 98 0.125
negative regulation of defense response GO:0031348 47 0.124
response to interferon gamma GO:0034341 39 0.124
carboxylic acid transport GO:0046942 63 0.124
organic hydroxy compound transport GO:0015850 63 0.124
homeostasis of number of cells GO:0048872 40 0.122
viral process GO:0016032 146 0.117
regulation of dna metabolic process GO:0051052 153 0.116
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.115
intracellular receptor signaling pathway GO:0030522 104 0.113
Mouse
cation transport GO:0006812 331 0.110
interleukin 6 mediated signaling pathway GO:0070102 7 0.110
negative regulation of nf kappab import into nucleus GO:0042347 12 0.110
positive regulation of cell proliferation GO:0008284 301 0.109
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.107
glycosaminoglycan metabolic process GO:0030203 35 0.106
regulation of cell activation GO:0050865 125 0.106
regulation of cell cycle GO:0051726 393 0.105
positive regulation of type i interferon production GO:0032481 20 0.104
protein targeting GO:0006605 187 0.101
cellular homeostasis GO:0019725 196 0.100
regulation of protein stability GO:0031647 87 0.099
lipid storage GO:0019915 28 0.099
t cell activation GO:0042110 99 0.098
purine ribonucleoside metabolic process GO:0046128 437 0.098
negative regulation of embryonic development GO:0045992 4 0.097
organic hydroxy compound metabolic process GO:1901615 147 0.097
antigen processing and presentation GO:0019882 33 0.096
cellular response to starvation GO:0009267 58 0.096
positive regulation of translation GO:0045727 35 0.095
Human
nitric oxide metabolic process GO:0046209 22 0.095
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.095
regulation of transferase activity GO:0051338 355 0.094
regulation of lipid storage GO:0010883 21 0.093
signal transduction by p53 class mediator GO:0072331 72 0.093
Human
positive regulation of cell migration GO:0030335 172 0.093
regulation of cell adhesion GO:0030155 166 0.091
cytosolic calcium ion homeostasis GO:0051480 89 0.091
cellular protein catabolic process GO:0044257 261 0.091
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 12 0.089
Mouse
foam cell differentiation GO:0090077 15 0.089
neurogenesis GO:0022008 169 0.087
organic anion transport GO:0015711 103 0.087
cholesterol efflux GO:0033344 28 0.085
regulation of insulin receptor signaling pathway GO:0046626 13 0.085
b cell activation GO:0042113 33 0.085
determination of adult lifespan GO:0008340 2 0.084
segmentation GO:0035282 4 0.084
negative regulation of cellular protein metabolic process GO:0032269 353 0.083
vitamin d biosynthetic process GO:0042368 9 0.083
cytoplasmic sequestering of transcription factor GO:0042994 9 0.082
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.082
jnk cascade GO:0007254 80 0.082
cellular response to peptide hormone stimulus GO:0071375 56 0.081
regulation of hyaluronan biosynthetic process GO:1900125 6 0.081
regulation of autophagy GO:0010506 52 0.081
regulation of angiogenesis GO:0045765 92 0.080
neuron development GO:0048666 113 0.079
response to alkaloid GO:0043279 20 0.078
multi organism cellular process GO:0044764 156 0.078
regulation of smooth muscle cell proliferation GO:0048660 28 0.076
interleukin 6 production GO:0032635 37 0.075
regulation of mitotic cell cycle GO:0007346 189 0.075
negative regulation of phosphorus metabolic process GO:0010563 267 0.074
divalent inorganic cation homeostasis GO:0072507 136 0.074
alcohol metabolic process GO:0006066 114 0.074
response to extracellular stimulus GO:0009991 85 0.074
peptidyl lysine modification GO:0018205 144 0.074
regulation of microtubule cytoskeleton organization GO:0070507 61 0.073
cellular response to monosaccharide stimulus GO:0071326 10 0.073
toll like receptor signaling pathway GO:0002224 25 0.073
Mouse
regulation of alcohol biosynthetic process GO:1902930 22 0.072
biological adhesion GO:0022610 331 0.072
regulation of monooxygenase activity GO:0032768 22 0.072
regulation of meiotic cell cycle GO:0051445 4 0.071
mirna metabolic process GO:0010586 10 0.071
negative regulation of phosphate metabolic process GO:0045936 267 0.071
generation of neurons GO:0048699 152 0.070
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.070
positive regulation of lipid metabolic process GO:0045834 50 0.070
nucleoside phosphate catabolic process GO:1901292 412 0.070
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.069
response to acid chemical GO:0001101 66 0.069
negative regulation of immune system process GO:0002683 136 0.069
Mouse
response to peptide hormone GO:0043434 61 0.068
myeloid leukocyte activation GO:0002274 34 0.068
cell type specific apoptotic process GO:0097285 125 0.068
response to endoplasmic reticulum stress GO:0034976 49 0.067
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.067
aminoglycan biosynthetic process GO:0006023 29 0.067
regulation of proteasomal protein catabolic process GO:0061136 87 0.067
negative regulation of leukocyte differentiation GO:1902106 24 0.066
leukocyte apoptotic process GO:0071887 31 0.065
cellular response to nutrient levels GO:0031669 69 0.064
negative regulation of steroid biosynthetic process GO:0010894 15 0.064
negative regulation of protein phosphorylation GO:0001933 140 0.063
sodium ion transport GO:0006814 61 0.063
cellular chemical homeostasis GO:0055082 180 0.063
cell projection organization GO:0030030 252 0.062
maintenance of protein location GO:0045185 57 0.062
positive regulation of cellular catabolic process GO:0031331 284 0.062
t helper 1 cell differentiation GO:0045063 1 0.062
maintenance of location GO:0051235 112 0.062
negative regulation of lipopolysaccharide mediated signaling pathway GO:0031665 7 0.059
positive regulation of protein localization to nucleus GO:1900182 48 0.058
regulation of cellular response to stress GO:0080135 244 0.058
positive regulation of protein phosphorylation GO:0001934 313 0.057
organ morphogenesis GO:0009887 147 0.057
glycosyl compound catabolic process GO:1901658 413 0.056
regulation of cytoskeleton organization GO:0051493 177 0.056
cellular amino acid metabolic process GO:0006520 116 0.056
positive regulation of intracellular protein transport GO:0090316 76 0.056
dna repair GO:0006281 198 0.055
positive regulation of carbohydrate metabolic process GO:0045913 21 0.055
i kappab phosphorylation GO:0007252 7 0.055
positive regulation of cell death GO:0010942 263 0.054
regulation of carbohydrate metabolic process GO:0006109 54 0.054
regulation of polysaccharide metabolic process GO:0032881 21 0.054
circadian sleep wake cycle process GO:0022410 2 0.054
blood vessel morphogenesis GO:0048514 162 0.054
t cell differentiation involved in immune response GO:0002292 7 0.053
cellular response to external stimulus GO:0071496 111 0.053
single organism cell adhesion GO:0098602 179 0.053
response to interleukin 1 GO:0070555 47 0.052
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.051
neuron differentiation GO:0030182 138 0.051
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.050
regulation of cell cycle phase transition GO:1901987 126 0.050
multicellular organism reproduction GO:0032504 42 0.050
Fly
regulation of dna binding GO:0051101 37 0.050
Human
negative regulation of response to wounding GO:1903035 47 0.050
regulation of steroid metabolic process GO:0019218 32 0.050
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.050
response to uv b GO:0010224 10 0.049
cell morphogenesis GO:0000902 296 0.049
regulation of jak stat cascade GO:0046425 44 0.048
developmental process involved in reproduction GO:0003006 66 0.048
Fly
regulation of protein catabolic process GO:0042176 155 0.048
cell division GO:0051301 168 0.048
negative regulation of lipid metabolic process GO:0045833 38 0.047
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.047
positive regulation of transcription factor import into nucleus GO:0042993 25 0.047
acute phase response GO:0006953 5 0.047
regulation of stem cell proliferation GO:0072091 15 0.046
protein deubiquitination GO:0016579 79 0.046

NFKBIA disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.866
organ system cancer DOID:0050686 164 0.866
cancer DOID:162 167 0.866
immune system disease DOID:2914 155 0.472
b cell deficiency DOID:2115 17 0.472
primary immunodeficiency disease DOID:612 36 0.472
agammaglobulinemia DOID:2583 16 0.461
hematopoietic system disease DOID:74 100 0.461
blood protein disease DOID:620 16 0.461
disease by infectious agent DOID:0050117 34 0.062