Rattus norvegicus

0 known processes

Mcpt8

mast cell protease 8

(Aliases: RMCP8)

Mcpt8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of necroptotic process GO:0060544 2 0.983
Rat
necroptotic process GO:0070266 2 0.844
Rat
positive regulation of necrotic cell death GO:0010940 4 0.628
Rat
programmed necrotic cell death GO:0097300 2 0.586
Rat
positive regulation of necroptotic process GO:0060545 2 0.521
Rat
response to bacterium GO:0009617 200 0.348
response to biotic stimulus GO:0009607 226 0.342
leukocyte cell cell adhesion GO:0007159 4 0.276
immune system process GO:0002376 204 0.257
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 1 0.241
natural killer cell mediated immune response to tumor cell GO:0002423 1 0.181
response to external biotic stimulus GO:0043207 221 0.148
defense response GO:0006952 194 0.146
negative regulation of natural killer cell mediated immune response to tumor cell GO:0002856 1 0.143
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002858 1 0.142
regulation of natural killer cell mediated immune response to tumor cell GO:0002855 1 0.129
response to other organism GO:0051707 220 0.120
proteolysis GO:0006508 175 0.110
Rat
cellular response to nitrogen compound GO:1901699 210 0.100
immune response GO:0006955 104 0.098
negative regulation of immune response to tumor cell GO:0002838 2 0.092
regulation of cell killing GO:0031341 12 0.086
response to extracellular stimulus GO:0009991 380 0.083
positive regulation of programmed cell death GO:0043068 157 0.082
Rat
helper t cell diapedesis GO:0035685 1 0.077
positive regulation of interleukin 1 alpha biosynthetic process GO:0050726 1 0.077
response to tumor cell GO:0002347 4 0.076
intracellular signal transduction GO:0035556 314 0.075
regulation of multicellular organismal development GO:2000026 376 0.074
positive regulation of phosphate metabolic process GO:0045937 262 0.071
protein complex biogenesis GO:0070271 263 0.069
programmed cell death GO:0012501 392 0.068
Rat
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.065
immune response to tumor cell GO:0002418 3 0.065
small molecule biosynthetic process GO:0044283 124 0.064
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.062
hormone metabolic process GO:0042445 69 0.062
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.061
regulation of cellular component organization GO:0051128 368 0.057
innate immune response GO:0045087 35 0.056
natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002420 1 0.056
fat soluble vitamin biosynthetic process GO:0042362 2 0.055
negative regulation of response to tumor cell GO:0002835 2 0.052
response to nutrient levels GO:0031667 370 0.052
protein complex subunit organization GO:0071822 302 0.052
positive regulation of cell death GO:0010942 184 0.051
Rat
regulation of molecular function GO:0065009 398 0.051
cellular component biogenesis GO:0044085 368 0.049
negative regulation of cellular metabolic process GO:0031324 281 0.048
single organism reproductive process GO:0044702 297 0.048
regulation of immune response to tumor cell GO:0002837 3 0.048
response to carbohydrate GO:0009743 183 0.048
macromolecular complex assembly GO:0065003 273 0.046
regulation of cellular ketone metabolic process GO:0010565 27 0.046
response to glucose GO:0009749 136 0.046
cell activation GO:0001775 97 0.045
response to monosaccharide GO:0034284 159 0.045
cellular response to oxygen containing compound GO:1901701 386 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.044
rna metabolic process GO:0016070 406 0.044
response to hydrogen peroxide GO:0042542 89 0.043
regulation of rna biosynthetic process GO:2001141 381 0.043
positive regulation of phosphorylation GO:0042327 177 0.043
cellular ketone metabolic process GO:0042180 51 0.043
carboxylic acid metabolic process GO:0019752 289 0.042
single organism biosynthetic process GO:0044711 342 0.041
regulation of hormone levels GO:0010817 187 0.041
negative regulation of innate immune response GO:0045824 4 0.040
positive regulation of natural killer cell mediated immunity GO:0002717 2 0.039
protein phosphorylation GO:0006468 345 0.039
response to estrogen GO:0043627 232 0.039
cellular response to stress GO:0033554 269 0.038
cellular response to vitamin k GO:0071307 1 0.038
positive regulation of cellular biosynthetic process GO:0031328 295 0.038
regulation of nervous system development GO:0051960 264 0.038
response to lipopolysaccharide GO:0032496 191 0.037
negative regulation of gene expression GO:0010629 199 0.037
positive regulation of molecular function GO:0044093 230 0.037
cellular response to interleukin 1 GO:0071347 37 0.037
response to hexose GO:0009746 144 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
homeostatic process GO:0042592 331 0.035
central nervous system development GO:0007417 311 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.034
regulation of neurogenesis GO:0050767 247 0.034
cell killing GO:0001906 13 0.034
regulation of natural killer cell mediated immunity GO:0002715 6 0.034
cellular response to cytokine stimulus GO:0071345 127 0.033
fever generation GO:0001660 9 0.033
taxis GO:0042330 67 0.033
regulation of catalytic activity GO:0050790 304 0.033
cell adhesion GO:0007155 110 0.033
positive regulation of protein phosphorylation GO:0001934 135 0.032
positive regulation of cell killing GO:0031343 9 0.032
response to molecule of bacterial origin GO:0002237 194 0.032
regulation of response to tumor cell GO:0002834 3 0.032
regulation of secretion by cell GO:1903530 208 0.032
regulation of signal transduction GO:0009966 318 0.031
protein oligomerization GO:0051259 191 0.031
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.031
jak stat cascade GO:0007259 26 0.030
steroid biosynthetic process GO:0006694 48 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
reproduction GO:0000003 245 0.029
cellular response to biotic stimulus GO:0071216 59 0.029
cellular component assembly GO:0022607 360 0.029
response to alkyl hydroperoxide GO:0033195 1 0.029
protein complex assembly GO:0006461 263 0.028
ion homeostasis GO:0050801 212 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
cell projection organization GO:0030030 302 0.028
neuron differentiation GO:0030182 368 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
cellular amine metabolic process GO:0044106 38 0.027
response to cytokine GO:0034097 215 0.027
regulation of cell development GO:0060284 263 0.026
chemical homeostasis GO:0048878 292 0.026
negative regulation of nucleic acid templated transcription GO:1903507 117 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
positive regulation of cell proliferation GO:0008284 249 0.026
transcription dna templated GO:0006351 377 0.026
negative regulation of rna metabolic process GO:0051253 123 0.026
response to interleukin 13 GO:0035962 3 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
anion transport GO:0006820 178 0.025
regulation of protein metabolic process GO:0051246 289 0.024
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 2 0.024
regulation of cell differentiation GO:0045595 320 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
natural killer cell mediated cytotoxicity GO:0042267 6 0.024
organic acid biosynthetic process GO:0016053 83 0.023
response to wounding GO:0009611 254 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
multi organism reproductive process GO:0044703 262 0.023
myeloid leukocyte activation GO:0002274 36 0.023
carbohydrate homeostasis GO:0033500 75 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
negative regulation of biosynthetic process GO:0009890 168 0.023
inflammatory response GO:0006954 150 0.022
response to growth factor GO:0070848 189 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.022
lipid biosynthetic process GO:0008610 128 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
positive regulation of neurogenesis GO:0050769 165 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.021
cellular response to alcohol GO:0097306 87 0.021
reproductive process GO:0022414 372 0.021
regulation of interferon gamma production GO:0032649 3 0.021
response to food GO:0032094 27 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.020
alcohol metabolic process GO:0006066 77 0.020
purine containing compound metabolic process GO:0072521 253 0.020
t helper 1 cell extravasation GO:0035687 1 0.020
response to amino acid GO:0043200 75 0.020
regulation of rna metabolic process GO:0051252 391 0.020
monocarboxylic acid transport GO:0015718 52 0.020
cellular lipid metabolic process GO:0044255 208 0.020
regulation of phosphorylation GO:0042325 248 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
peptide biosynthetic process GO:0043043 3 0.020
cellular response to hexose stimulus GO:0071331 65 0.020
response to vitamin k GO:0032571 4 0.020
negative regulation of response to stimulus GO:0048585 155 0.020
rna biosynthetic process GO:0032774 380 0.019
inorganic ion transmembrane transport GO:0098660 229 0.019
cellular response to lipid GO:0071396 201 0.019
response to inorganic substance GO:0010035 377 0.019
cellular response to endogenous stimulus GO:0071495 377 0.019
lipid metabolic process GO:0006629 283 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
response to oxidative stress GO:0006979 186 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
vitamin d metabolic process GO:0042359 4 0.019
response to purine containing compound GO:0014074 126 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
nitrogen compound transport GO:0071705 229 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
positive regulation of defense response GO:0031349 37 0.018
apoptotic process GO:0006915 381 0.018
cellular response to molecule of bacterial origin GO:0071219 56 0.018
response to decreased oxygen levels GO:0036293 237 0.018
response to nutrient GO:0007584 248 0.018
locomotion GO:0040011 237 0.018
cell type specific apoptotic process GO:0097285 134 0.018
organophosphate metabolic process GO:0019637 370 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
regulation of programmed cell death GO:0043067 341 0.018
Rat
response to interleukin 1 GO:0070555 55 0.018
response to alkaloid GO:0043279 132 0.018
cellular chemical homeostasis GO:0055082 247 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.018
response to vitamin GO:0033273 131 0.017
vitamin biosynthetic process GO:0009110 3 0.017
vesicle mediated transport GO:0016192 181 0.017
cytokine production GO:0001816 61 0.017
cellular response to external stimulus GO:0071496 118 0.017
spermatogenesis GO:0007283 99 0.017
cytolysis GO:0019835 4 0.017
circadian rhythm GO:0007623 88 0.017
positive regulation of gene expression GO:0010628 244 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
amine metabolic process GO:0009308 38 0.017
positive regulation of nervous system development GO:0051962 178 0.017
mast cell migration GO:0097531 4 0.017
response to acid chemical GO:0001101 222 0.016
regulation of secretion GO:0051046 224 0.016
aging GO:0007568 241 0.016
response to high density lipoprotein particle GO:0055099 2 0.016
cytokine biosynthetic process GO:0042089 3 0.016
acute inflammatory response GO:0002526 58 0.016
positive regulation of cell development GO:0010720 176 0.016
positive regulation of hydrolase activity GO:0051345 86 0.016
regulation of proteolysis GO:0030162 66 0.016
positive regulation of signal transduction GO:0009967 175 0.016
protein maturation GO:0051604 68 0.016
organic hydroxy compound metabolic process GO:1901615 115 0.016
lipid transport GO:0006869 61 0.016
regulation of t cell chemotaxis GO:0010819 1 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.016
negative regulation of signaling GO:0023057 157 0.015
lymphocyte activation GO:0046649 43 0.015
negative regulation of viral process GO:0048525 4 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
cellular homeostasis GO:0019725 252 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
behavior GO:0007610 205 0.015
male gamete generation GO:0048232 99 0.015
response to toxic substance GO:0009636 133 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
regulation of innate immune response GO:0045088 15 0.015
response to corticosteroid GO:0031960 235 0.014
cellular hormone metabolic process GO:0034754 49 0.014
response to hyperoxia GO:0055093 45 0.014
single organism organelle organization GO:1902589 180 0.014
acute phase response GO:0006953 20 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
erythrocyte differentiation GO:0030218 1 0.014
nucleic acid templated transcription GO:0097659 379 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
intracellular transport GO:0046907 185 0.014
regulation of natural killer cell mediated cytotoxicity GO:0042269 6 0.014
regulation of protein modification process GO:0031399 194 0.014
interleukin 1 production GO:0032612 11 0.014
axis specification GO:0009798 4 0.013
regulation of transcription dna templated GO:0006355 374 0.013
gamete generation GO:0007276 124 0.013
cellular response to ammonium ion GO:0071242 17 0.013
immune system development GO:0002520 41 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
single organism intracellular transport GO:1902582 166 0.013
sexual reproduction GO:0019953 148 0.013
oxidation reduction process GO:0055114 304 0.013
cellular response to isoquinoline alkaloid GO:0071317 6 0.013
macromolecule localization GO:0033036 252 0.013
peptide metabolic process GO:0006518 32 0.013
activation of cysteine type endopeptidase activity GO:0097202 4 0.013
negative regulation of lymphocyte mediated immunity GO:0002707 5 0.013
positive regulation of developmental process GO:0051094 283 0.013
gastrulation GO:0007369 2 0.013
leukocyte mediated cytotoxicity GO:0001909 10 0.013
t cell migration GO:0072678 2 0.013
regulation of cell proliferation GO:0042127 359 0.013
olfactory behavior GO:0042048 2 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
cellular response to oxidative stress GO:0034599 76 0.013
response to morphine GO:0043278 27 0.013
regulation of fever generation GO:0031620 6 0.012
protein homooligomerization GO:0051260 91 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
positive regulation of transferase activity GO:0051347 81 0.012
circulatory system process GO:0003013 183 0.012
positive regulation of cell communication GO:0010647 271 0.012
oxoacid metabolic process GO:0043436 290 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
peptidyl amino acid modification GO:0018193 126 0.012
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.012
hemopoiesis GO:0030097 34 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
negative regulation of metabolic process GO:0009892 331 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
cellular glucose homeostasis GO:0001678 66 0.012
response to radiation GO:0009314 137 0.012
localization of cell GO:0051674 202 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
cellular amide metabolic process GO:0043603 44 0.012
regulation of ion transport GO:0043269 245 0.012
neuron development GO:0048666 286 0.012
regulation of neuron differentiation GO:0045664 208 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
brain development GO:0007420 247 0.012
regulation of immune system process GO:0002682 123 0.012
cellular response to glucose stimulus GO:0071333 65 0.012
positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 0.012
chemosensory behavior GO:0007635 2 0.012
interleukin 1 biosynthetic process GO:0042222 1 0.011
lipid localization GO:0010876 62 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
positive regulation of immune response GO:0050778 42 0.011
organic acid metabolic process GO:0006082 292 0.011
regulation of lymphocyte chemotaxis GO:1901623 1 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
organic hydroxy compound biosynthetic process GO:1901617 51 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
positive regulation of calcium ion transport GO:0051928 36 0.011
adult locomotory behavior GO:0008344 4 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
regulation of transmembrane transport GO:0034762 122 0.011
positive regulation of interleukin 1 alpha production GO:0032730 1 0.011
glucose homeostasis GO:0042593 75 0.011
response to glucocorticoid GO:0051384 223 0.011
regulation of neuron death GO:1901214 115 0.011
pseudopodium assembly GO:0031269 3 0.011
response to oxygen levels GO:0070482 265 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
immune effector process GO:0002252 53 0.011
regulation of interleukin 1 alpha production GO:0032650 1 0.011
reproductive system development GO:0061458 128 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
cellular response to hydroperoxide GO:0071447 2 0.011
vitamin d biosynthetic process GO:0042368 2 0.011
mesoderm development GO:0007498 2 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
response to starvation GO:0042594 59 0.010
regulation of insulin secretion GO:0050796 65 0.010
nucleotide metabolic process GO:0009117 279 0.010
response to activity GO:0014823 73 0.010
cellular ion homeostasis GO:0006873 184 0.010
negative regulation of leukocyte mediated immunity GO:0002704 6 0.010
cellular response to carbohydrate stimulus GO:0071322 72 0.010
t cell homeostasis GO:0043029 2 0.010
embryonic pattern specification GO:0009880 1 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
carboxylic acid biosynthetic process GO:0046394 83 0.010
centrosome organization GO:0051297 1 0.010
cytoplasmic transport GO:0016482 115 0.010
cellular response to nutrient GO:0031670 30 0.010
female pregnancy GO:0007565 122 0.010
leukocyte differentiation GO:0002521 30 0.010
negative regulation of cell death GO:0060548 229 0.010
interleukin 1 alpha production GO:0032610 1 0.010
positive regulation of response to stimulus GO:0048584 285 0.010

Mcpt8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
disease of metabolism DOID:0014667 0 0.016
acquired metabolic disease DOID:0060158 0 0.014
immune system disease DOID:2914 0 0.012
disease of anatomical entity DOID:7 0 0.012