IMP

Process View

Homo sapiens

4 genes annotated in human

angiotensin activated signaling pathway

The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "angiotensin activated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
RLN3	relaxin 3	0.994
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.907
TIMP3	TIMP metallopeptidase inhibitor 3	0.809
SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	0.575
ARRB1	arrestin, beta 1	0.263
BDKRB1	bradykinin receptor B1	0.149	Human
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.085
BDKRB2	bradykinin receptor B2	0.080	Human
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.064
EPB42	erythrocyte membrane protein band 4.2	0.041
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.035
GLYAT	glycine-N-acyltransferase	0.033
OVGP1	oviductal glycoprotein 1, 120kDa	0.032
ING2	inhibitor of growth family, member 2	0.031
RHAG	Rh-associated glycoprotein	0.030
AMPD1	adenosine monophosphate deaminase 1	0.030
TLX1	T-cell leukemia homeobox 1	0.030
ZNF273	zinc finger protein 273	0.029
MS4A12	membrane-spanning 4-domains, subfamily A, member 12	0.027
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.027
KNG1	kininogen 1	0.027
AGXT	alanine-glyoxylate aminotransferase	0.026
DAO	D-amino-acid oxidase	0.026
FABP1	fatty acid binding protein 1, liver	0.026
ALPI	alkaline phosphatase, intestinal	0.026
EEA1	early endosome antigen 1	0.025
CST5	cystatin D	0.025
AHSP	alpha hemoglobin stabilizing protein	0.025
TSHB	thyroid stimulating hormone, beta	0.024
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	0.023
CPB2	carboxypeptidase B2 (plasma)	0.023
FZD9	frizzled homolog 9 (Drosophila)	0.023
GPR31	G protein-coupled receptor 31	0.022
CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8	0.022
PLEKHG6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.022
C4BPA	complement component 4 binding protein, alpha	0.022
PNLIPRP1	pancreatic lipase-related protein 1	0.022
CCR4	chemokine (C-C motif) receptor 4	0.021
PDZD3	PDZ domain containing 3	0.021
GPA33	glycoprotein A33 (transmembrane)	0.020
PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	0.020
MAS1	MAS1 oncogene	0.020	Mouse Rat
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.020
TNNI2	troponin I type 2 (skeletal, fast)	0.020
KLK1	kallikrein 1	0.020
DEFA4	defensin, alpha 4, corticostatin	0.020
ACAN	aggrecan	0.020
XRN1	5'-3' exoribonuclease 1	0.019
PRRX2	paired related homeobox 2	0.019
OTC	ornithine carbamoyltransferase	0.019
SPATS1	spermatogenesis associated, serine-rich 1	0.019
ATP10B	ATPase, class V, type 10B	0.019
GPR12	G protein-coupled receptor 12	0.019
NGB	neuroglobin	0.019
HBD	hemoglobin, delta	0.019
KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	0.018
CLDN14	claudin 14	0.018
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.018
RAX	retina and anterior neural fold homeobox	0.018
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.018
LIPC	lipase, hepatic	0.018
BTNL3	butyrophilin-like 3	0.018
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.018
PI15	peptidase inhibitor 15	0.018
ERN2	endoplasmic reticulum to nucleus signaling 2	0.017
EDN2	endothelin 2	0.017
CTRC	chymotrypsin C (caldecrin)	0.017
MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	0.017
PADI4	peptidyl arginine deiminase, type IV	0.017
SSX5	synovial sarcoma, X breakpoint 5	0.017
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.017
AVPR2	arginine vasopressin receptor 2	0.017
PDE6A	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.017
GYPB	glycophorin B (MNS blood group)	0.017
SARDH	sarcosine dehydrogenase	0.017
PAPD4	PAP associated domain containing 4	0.017
BMX	BMX non-receptor tyrosine kinase	0.017
NOX1	NADPH oxidase 1	0.017
PDCD1	programmed cell death 1	0.016
ALOX15B	arachidonate 15-lipoxygenase, type B	0.016
KRT83	keratin 83	0.016
CD177	CD177 molecule	0.016
PON1	paraoxonase 1	0.016
PGC	progastricsin (pepsinogen C)	0.016
STC1	stanniocalcin 1	0.016
FABP2	fatty acid binding protein 2, intestinal	0.016
CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	0.016
PON3	paraoxonase 3	0.016
BPI	bactericidal/permeability-increasing protein	0.016
MAPK10	mitogen-activated protein kinase 10	0.016
AQP8	aquaporin 8	0.016
BCL2L14	BCL2-like 14 (apoptosis facilitator)	0.016
HAVCR1	hepatitis A virus cellular receptor 1	0.015
CXCR1	chemokine (C-X-C motif) receptor 1	0.015
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.015
IL1RL2	interleukin 1 receptor-like 2	0.015
CCL24	chemokine (C-C motif) ligand 24	0.015
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.015
EPX	eosinophil peroxidase	0.015
VIPR1	vasoactive intestinal peptide receptor 1	0.015
RORC	RAR-related orphan receptor C	0.015
TNK1	tyrosine kinase, non-receptor, 1	0.015
IFNA21	interferon, alpha 21	0.015
CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	0.015
PTPRH	protein tyrosine phosphatase, receptor type, H	0.015
BTNL8	butyrophilin-like 8	0.015
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.015
CD207	CD207 molecule, langerin	0.014
NEU2	sialidase 2 (cytosolic sialidase)	0.014
EGLN3	egl nine homolog 3 (C. elegans)	0.014
GNMT	glycine N-methyltransferase	0.014
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	0.014
ALPP	alkaline phosphatase, placental	0.014
KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	0.014
MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.014
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.014
FGFBP1	fibroblast growth factor binding protein 1	0.014
C8B	complement component 8, beta polypeptide	0.014
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.014
OR51E2	olfactory receptor, family 51, subfamily E, member 2	0.014
RCVRN	recoverin	0.014
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.014
CMA1	chymase 1, mast cell	0.014
OR2C1	olfactory receptor, family 2, subfamily C, member 1	0.014
SOAT2	sterol O-acyltransferase 2	0.014
PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	0.014
PSG2	pregnancy specific beta-1-glycoprotein 2	0.014
FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	0.014
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.014
REG1A	regenerating islet-derived 1 alpha	0.014
C6orf105	chromosome 6 open reading frame 105	0.014
TG	thyroglobulin	0.014
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	0.014
PRKG2	protein kinase, cGMP-dependent, type II	0.013
GUCA1A	guanylate cyclase activator 1A (retina)	0.013
CHST5	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	0.013
MYO1A	myosin IA	0.013
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	0.013
ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	0.013
HBB	hemoglobin, beta	0.013
FAM55D	family with sequence similarity 55, member D	0.013
PSG3	pregnancy specific beta-1-glycoprotein 3	0.013
PRDX2	peroxiredoxin 2	0.013
TMEM40	transmembrane protein 40	0.013
EFNA2	ephrin-A2	0.013
NPY5R	neuropeptide Y receptor Y5	0.013
ORM2	orosomucoid 2	0.013
PRB1	proline-rich protein BstNI subfamily 1	0.013
CARD14	caspase recruitment domain family, member 14	0.013
SPINK4	serine peptidase inhibitor, Kazal type 4	0.013
CILP	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	0.013
SPINK2	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)	0.013
TM7SF4	transmembrane 7 superfamily member 4	0.013
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.013
REG3A	regenerating islet-derived 3 alpha	0.013
CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	0.013
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.013
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.013
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.013
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.013
PTPRR	protein tyrosine phosphatase, receptor type, R	0.013
CNR2	cannabinoid receptor 2 (macrophage)	0.013
TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
TAT	tyrosine aminotransferase	0.012
CAPN6	calpain 6	0.012
GH2	growth hormone 2	0.012
KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	0.012
RAPSN	receptor-associated protein of the synapse	0.012
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.012
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.012
SRY	sex determining region Y	0.012
ANGPTL4	angiopoietin-like 4	0.012
CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	0.012
KLRG1	killer cell lectin-like receptor subfamily G, member 1	0.012
BMP3	bone morphogenetic protein 3	0.012
LGALS4	lectin, galactoside-binding, soluble, 4	0.012
FMO4	flavin containing monooxygenase 4	0.012
CTRL	chymotrypsin-like	0.012
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.012
XDH	xanthine dehydrogenase	0.012
CA12	carbonic anhydrase XII	0.012
SCGN	secretagogin, EF-hand calcium binding protein	0.012
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.012
TGM5	transglutaminase 5	0.012
MC5R	melanocortin 5 receptor	0.012
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	0.012
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.012
CALCRL	calcitonin receptor-like	0.012
INS	insulin	0.012
GPR35	G protein-coupled receptor 35	0.012
SLC1A7	solute carrier family 1 (glutamate transporter), member 7	0.012
B3GNT4	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4	0.012
SERPINB10	serpin peptidase inhibitor, clade B (ovalbumin), member 10	0.012
KRT2	keratin 2	0.012
NXPH3	neurexophilin 3	0.012
PLA2G5	phospholipase A2, group V	0.012
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.012
FOXD2	forkhead box D2	0.012
LDHC	lactate dehydrogenase C	0.012
CHRM5	cholinergic receptor, muscarinic 5	0.012
PSG11	pregnancy specific beta-1-glycoprotein 11	0.012
FOXI1	forkhead box I1	0.012
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.012
ITGA10	integrin, alpha 10	0.012
ZNF192	zinc finger protein 192	0.012
MYOM1	myomesin 1, 185kDa	0.012
DGKG	diacylglycerol kinase, gamma 90kDa	0.012
TEC	tec protein tyrosine kinase	0.012
KRT14	keratin 14	0.012
GRPR	gastrin-releasing peptide receptor	0.012
HPD	4-hydroxyphenylpyruvate dioxygenase	0.012
CACNG1	calcium channel, voltage-dependent, gamma subunit 1	0.012
SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	0.012
SLC38A3	solute carrier family 38, member 3	0.012
PHF7	PHD finger protein 7	0.012
ESRRB	estrogen-related receptor beta	0.012
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.012
TNNT3	troponin T type 3 (skeletal, fast)	0.012
CRHR2	corticotropin releasing hormone receptor 2	0.012
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.012
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.012
ACSM1	acyl-CoA synthetase medium-chain family member 1	0.012
RLN1	relaxin 1	0.012
DUOX2	dual oxidase 2	0.012
HAL	histidine ammonia-lyase	0.011
PIPOX	pipecolic acid oxidase	0.011
CD5	CD5 molecule	0.011
GH1	growth hormone 1	0.011
BMPR1B	bone morphogenetic protein receptor, type IB	0.011
SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	0.011
AADAC	arylacetamide deacetylase (esterase)	0.011
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.011
KRT37	keratin 37	0.011
HIST1H3J	histone cluster 1, H3j	0.011
ALAS2	aminolevulinate, delta-, synthase 2	0.011
TAS2R1	taste receptor, type 2, member 1	0.011
CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	0.011
ALOX12	arachidonate 12-lipoxygenase	0.011
GRRP1	glycine/arginine rich protein 1	0.011
GIP	gastric inhibitory polypeptide	0.011
CSHL1	chorionic somatomammotropin hormone-like 1	0.011
DMBT1	deleted in malignant brain tumors 1	0.011
REN	renin	0.011
SLC39A5	solute carrier family 39 (metal ion transporter), member 5	0.011
OPN1SW	opsin 1 (cone pigments), short-wave-sensitive	0.011
TIMP4	TIMP metallopeptidase inhibitor 4	0.011
SPINK5	serine peptidase inhibitor, Kazal type 5	0.011
GPR182	G protein-coupled receptor 182	0.011
HOXD10	homeobox D10	0.011
STAB2	stabilin 2	0.011
ANXA13	annexin A13	0.011
CD36	CD36 molecule (thrombospondin receptor)	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
ELANE	elastase, neutrophil expressed	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
CDKL1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.011
FLT3	fms-related tyrosine kinase 3	0.011
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.011
SLC16A7	solute carrier family 16, member 7 (monocarboxylic acid transporter 2)	0.011
MLANA	melan-A	0.011
CCR9	chemokine (C-C motif) receptor 9	0.011
TECTA	tectorin alpha	0.011
IL13	interleukin 13	0.011
FOXN1	forkhead box N1	0.011
SEMG1	semenogelin I	0.011
KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	0.011
CXCR5	chemokine (C-X-C motif) receptor 5	0.011
TRPM6	transient receptor potential cation channel, subfamily M, member 6	0.011
ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	0.011
KCNAB3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.011
ODF1	outer dense fiber of sperm tails 1	0.011
CFHR2	complement factor H-related 2	0.011
USP42	ubiquitin specific peptidase 42	0.011
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.011
RNF122	ring finger protein 122	0.011
SLC28A3	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	0.011
CD226	CD226 molecule	0.011
PRSS50	protease, serine, 50	0.011
AMELY	amelogenin, Y-linked	0.011
TM4SF5	transmembrane 4 L six family member 5	0.011
TAC3	tachykinin 3	0.011
KRT75	keratin 75	0.011
SSTR1	somatostatin receptor 1	0.011
SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	0.011
TTC38	tetratricopeptide repeat domain 38	0.011
CHGA	chromogranin A (parathyroid secretory protein 1)	0.011
KRT13	keratin 13	0.011
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.011
CD40LG	CD40 ligand	0.011
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.011
ITPKC	inositol-trisphosphate 3-kinase C	0.011
MOSC1	MOCO sulphurase C-terminal domain containing 1	0.011
POU3F1	POU class 3 homeobox 1	0.011
BMP10	bone morphogenetic protein 10	0.011
PDE4C	phosphodiesterase 4C, cAMP-specific	0.011
PTTG2	pituitary tumor-transforming 2	0.011
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
SLC22A18AS	solute carrier family 22 (organic cation transporter), member 18 antisense	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.011
ASCL3	achaete-scute complex homolog 3 (Drosophila)	0.011
OR3A3	olfactory receptor, family 3, subfamily A, member 3	0.011
AQP6	aquaporin 6, kidney specific	0.011
CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	0.011
PRL	prolactin	0.011
C1orf183	chromosome 1 open reading frame 183	0.011
NKX3-1	NK3 homeobox 1	0.011
ZKSCAN3	zinc finger with KRAB and SCAN domains 3	0.010
TNNC2	troponin C type 2 (fast)	0.010
ZNF287	zinc finger protein 287	0.010
AVPR1B	arginine vasopressin receptor 1B	0.010
GABRR2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.010
FHOD1	formin homology 2 domain containing 1	0.010
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.010
SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	0.010
GDF2	growth differentiation factor 2	0.010
EGF	epidermal growth factor	0.010
DEFA6	defensin, alpha 6, Paneth cell-specific	0.010
SPAG4	sperm associated antigen 4	0.010
HAO2	hydroxyacid oxidase 2 (long chain)	0.010
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.010
ARSE	arylsulfatase E (chondrodysplasia punctata 1)	0.010
KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	0.010
SOX21	SRY (sex determining region Y)-box 21	0.010
TNMD	tenomodulin	0.010
HIST1H4D	histone cluster 1, H4d	0.010
P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	0.010
ADIPOQ	adiponectin, C1Q and collagen domain containing	0.010
CCDC54	coiled-coil domain containing 54	0.010
HESX1	HESX homeobox 1	0.010
STX1A	syntaxin 1A (brain)	0.010
PTCHD2	patched domain containing 2	0.010
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.010
NTN3	netrin 3	0.010
CTSE	cathepsin E	0.010
TRPA1	transient receptor potential cation channel, subfamily A, member 1	0.010
AFM	afamin	0.010
TLX3	T-cell leukemia homeobox 3	0.010
HIST1H2AB	histone cluster 1, H2ab	0.010
SPP2	secreted phosphoprotein 2, 24kDa	0.010
TXK	TXK tyrosine kinase	0.010
VPREB3	pre-B lymphocyte 3	0.010
CLCA1	chloride channel accessory 1	0.010
TMEM217	transmembrane protein 217	0.010
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.010
CER1	cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)	0.010
TMPRSS2	transmembrane protease, serine 2	0.010
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.010
MCTP2	multiple C2 domains, transmembrane 2	0.010
NMUR1	neuromedin U receptor 1	0.010
CD160	CD160 molecule	0.010
TDO2	tryptophan 2,3-dioxygenase	0.010
CELA1	chymotrypsin-like elastase family, member 1	0.010