IMP

Process View

Homo sapiens

3 genes annotated in human

tonic smooth muscle contraction

A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tonic smooth muscle contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tonic smooth muscle contraction" (in gray)

Name	Description	Probability	Func Analog Organism
UBQLN4	ubiquilin 4	0.920
CAV1	caveolin 1, caveolae protein, 22kDa	0.600
EDN1	endothelin 1	0.596
CEND1	cell cycle exit and neuronal differentiation 1	0.393
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.291
CAV2	caveolin 2	0.205
PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.133
CCDC14	coiled-coil domain containing 14	0.133
PCDH17	protocadherin 17	0.128
EDNRA	endothelin receptor type A	0.112
GKAP1	G kinase anchoring protein 1	0.111
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	0.099
PTN	pleiotrophin	0.095
CALCRL	calcitonin receptor-like	0.091
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.086
ANKRD13D	ankyrin repeat domain 13 family, member D	0.078
ZNF205	zinc finger protein 205	0.077
PICK1	protein interacting with PRKCA 1	0.071
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	0.068
ZG16B	zymogen granule protein 16 homolog B (rat)	0.066
SPAG8	sperm associated antigen 8	0.065
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.063
SCG2	secretogranin II	0.061
COL8A1	collagen, type VIII, alpha 1	0.057
FKBP2	FK506 binding protein 2, 13kDa	0.055
PTPRN	protein tyrosine phosphatase, receptor type, N	0.055
EGR4	early growth response 4	0.053
ADAM33	ADAM metallopeptidase domain 33	0.052
ERP27	endoplasmic reticulum protein 27	0.052
SCG5	secretogranin V (7B2 protein)	0.052
NPPA	natriuretic peptide A	0.052
KLHDC5	kelch domain containing 5	0.048
AGTR1	angiotensin II receptor, type 1	0.046
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.045
MCHR1	melanin-concentrating hormone receptor 1	0.044
DCN	decorin	0.043
NPY2R	neuropeptide Y receptor Y2	0.043
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.042
USMG5	up-regulated during skeletal muscle growth 5 homolog (mouse)	0.042
FZD7	frizzled homolog 7 (Drosophila)	0.041
ITPRIPL1	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	0.040
SPARCL1	SPARC-like 1 (hevin)	0.039
PAX2	paired box 2	0.038
COL4A1	collagen, type IV, alpha 1	0.036
RGS5	regulator of G-protein signaling 5	0.034
CCDC134	coiled-coil domain containing 134	0.032
RGS4	regulator of G-protein signaling 4	0.032
GJA1	gap junction protein, alpha 1, 43kDa	0.031
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.031
ELF5	E74-like factor 5 (ets domain transcription factor)	0.031
ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	0.030
LBX1	ladybird homeobox 1	0.029
SULF1	sulfatase 1	0.029
BCHE	butyrylcholinesterase	0.028
TFF1	trefoil factor 1	0.027
LAT2	linker for activation of T cells family, member 2	0.027
TRIM32	tripartite motif containing 32	0.026
SCAF1	SR-related CTD-associated factor 1	0.026
SERPINI2	serpin peptidase inhibitor, clade I (pancpin), member 2	0.026
NTM	neurotrimin	0.024
CDH5	cadherin 5, type 2 (vascular endothelium)	0.024
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.024
CRLF1	cytokine receptor-like factor 1	0.023
ENPEP	glutamyl aminopeptidase (aminopeptidase A)	0.023
RND3	Rho family GTPase 3	0.023
HK2	hexokinase 2	0.023
NID1	nidogen 1	0.022
DSPP	dentin sialophosphoprotein	0.021
NPHP1	nephronophthisis 1 (juvenile)	0.021
PTPRR	protein tyrosine phosphatase, receptor type, R	0.021
VGF	VGF nerve growth factor inducible	0.021
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	0.021
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.020
SEMG1	semenogelin I	0.020
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.020
BMP2	bone morphogenetic protein 2	0.020
FABP7	fatty acid binding protein 7, brain	0.019
FAM48A	family with sequence similarity 48, member A	0.019
NOTCH2NL	notch 2 N-terminal like	0.019
GPX7	glutathione peroxidase 7	0.019
TRIL	TLR4 interactor with leucine-rich repeats	0.019
ACCN1	amiloride-sensitive cation channel 1, neuronal	0.019
ADCY2	adenylate cyclase 2 (brain)	0.019
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.018
LHX1	LIM homeobox 1	0.018
CYR61	cysteine-rich, angiogenic inducer, 61	0.018
AREG	amphiregulin	0.018
TRIB2	tribbles homolog 2 (Drosophila)	0.017
GRIK1	glutamate receptor, ionotropic, kainate 1	0.017
VIP	vasoactive intestinal peptide	0.017
PDIA5	protein disulfide isomerase family A, member 5	0.017
SYT13	synaptotagmin XIII	0.017
PRKCDBP	protein kinase C, delta binding protein	0.017
SCMH1	sex comb on midleg homolog 1 (Drosophila)	0.017
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.017
TM4SF1	transmembrane 4 L six family member 1	0.016
ASPA	aspartoacylase	0.016
FGF18	fibroblast growth factor 18	0.016
KIF1A	kinesin family member 1A	0.016
BGN	biglycan	0.016
ZG16	zymogen granule protein 16 homolog (rat)	0.016
SPP1	secreted phosphoprotein 1	0.016
GFAP	glial fibrillary acidic protein	0.015
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.015
CDSN	corneodesmosin	0.015
JPH3	junctophilin 3	0.015
HUNK	hormonally up-regulated Neu-associated kinase	0.015
ZDHHC3	zinc finger, DHHC-type containing 3	0.015
TH	tyrosine hydroxylase	0.015
PCDH8	protocadherin 8	0.015
LRRN2	leucine rich repeat neuronal 2	0.015
FAM5B	family with sequence similarity 5, member B	0.014
PYY	peptide YY	0.014
F2R	coagulation factor II (thrombin) receptor	0.014
PTPRF	protein tyrosine phosphatase, receptor type, F	0.014
IGF1	insulin-like growth factor 1 (somatomedin C)	0.014
DAGLA	diacylglycerol lipase, alpha	0.014
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.014
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.014
HOXD10	homeobox D10	0.014
APOB	apolipoprotein B (including Ag(x) antigen)	0.014
CCDC107	coiled-coil domain containing 107	0.014
CTGF	connective tissue growth factor	0.014
RHBDL1	rhomboid, veinlet-like 1 (Drosophila)	0.013
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.013
PAX6	paired box 6	0.013
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	0.013
PRKCG	protein kinase C, gamma	0.013
SNAI2	snail homolog 2 (Drosophila)	0.013
HAVCR1	hepatitis A virus cellular receptor 1	0.013
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.013
LPPR4	lipid phosphate phosphatase-related protein type 4	0.013
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	0.013
KLHL1	kelch-like 1 (Drosophila)	0.013
EDNRB	endothelin receptor type B	0.013	Human
SCRG1	stimulator of chondrogenesis 1	0.013
GRP	gastrin-releasing peptide	0.013
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.013
CHGB	chromogranin B (secretogranin 1)	0.013
SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)	0.013
MYO1A	myosin IA	0.013
CD34	CD34 molecule	0.012
ASPN	asporin	0.012
EMCN	endomucin	0.012
TSPAN7	tetraspanin 7	0.012
GCGR	glucagon receptor	0.012
OPRK1	opioid receptor, kappa 1	0.012
SSTR5	somatostatin receptor 5	0.012
ZNF536	zinc finger protein 536	0.012
SOX17	SRY (sex determining region Y)-box 17	0.012
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.012
MDK	midkine (neurite growth-promoting factor 2)	0.012
NPAS3	neuronal PAS domain protein 3	0.012
MAGEL2	MAGE-like 2	0.012
AMOTL2	angiomotin like 2	0.012
GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.012
EMX2	empty spiracles homeobox 2	0.012
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.012
NME3	non-metastatic cells 3, protein expressed in	0.012
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.012
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.012
TTYH1	tweety homolog 1 (Drosophila)	0.012
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.011
CNTN1	contactin 1	0.011
ART3	ADP-ribosyltransferase 3	0.011
TAC1	tachykinin, precursor 1	0.011
PCP4	Purkinje cell protein 4	0.011
WIF1	WNT inhibitory factor 1	0.011
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.011
IL33	interleukin 33	0.011
SLC24A2	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	0.011
BDKRB1	bradykinin receptor B1	0.011
NID2	nidogen 2 (osteonidogen)	0.011
COL2A1	collagen, type II, alpha 1	0.011
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.011	Rat
ADCY8	adenylate cyclase 8 (brain)	0.011
LASS1	LAG1 homolog, ceramide synthase 1	0.011
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.011
CD93	CD93 molecule	0.011
WNT7A	wingless-type MMTV integration site family, member 7A	0.011
GPM6B	glycoprotein M6B	0.011
TRPC6	transient receptor potential cation channel, subfamily C, member 6	0.011
SDPR	serum deprivation response	0.011
KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.011
IGSF1	immunoglobulin superfamily, member 1	0.011
CALCA	calcitonin-related polypeptide alpha	0.010
FAT4	FAT tumor suppressor homolog 4 (Drosophila)	0.010
NPAS1	neuronal PAS domain protein 1	0.010
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.010
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.010
OMP	olfactory marker protein	0.010
ADRA1D	adrenergic, alpha-1D-, receptor	0.010
LSAMP	limbic system-associated membrane protein	0.010
IBSP	integrin-binding sialoprotein	0.010
CALY	calcyon neuron-specific vesicular protein	0.010
VAX2	ventral anterior homeobox 2	0.010
TGFB3	transforming growth factor, beta 3	0.010
PITX2	paired-like homeodomain 2	0.010
PLUNC	palate, lung and nasal epithelium associated	0.010
BAI1	brain-specific angiogenesis inhibitor 1	0.010
LHX2	LIM homeobox 2	0.010
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	0.010
COL3A1	collagen, type III, alpha 1	0.010
CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	0.010
TACR1	tachykinin receptor 1	0.010
BDNF	brain-derived neurotrophic factor	0.010
BHMT	betaine--homocysteine S-methyltransferase	0.010