IMP

Process View

Homo sapiens

1 genes annotated in human

spemann organizer formation

Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spemann organizer formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spemann organizer formation" (in gray)

Name	Description	Probability	Func Analog Organism
BBS10	Bardet-Biedl syndrome 10	0.981
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.863
WNT5A	wingless-type MMTV integration site family, member 5A	0.701
NDP	Norrie disease (pseudoglioma)	0.568
ELF5	E74-like factor 5 (ets domain transcription factor)	0.560
WNT3A	wingless-type MMTV integration site family, member 3A	0.258
EHF	ets homologous factor	0.213
OGN	osteoglycin	0.187
SFRP1	secreted frizzled-related protein 1	0.161
FBLN1	fibulin 1	0.097
FOXF2	forkhead box F2	0.089
RGS2	regulator of G-protein signaling 2, 24kDa	0.085
C7orf36	chromosome 7 open reading frame 36	0.075
GLT8D2	glycosyltransferase 8 domain containing 2	0.066
MXRA5	matrix-remodelling associated 5	0.060
LTBP2	latent transforming growth factor beta binding protein 2	0.057
FZD1	frizzled homolog 1 (Drosophila)	0.056	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.052
LRP6	low density lipoprotein receptor-related protein 6	0.050
CLEC3B	C-type lectin domain family 3, member B	0.049
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.042
EDNRA	endothelin receptor type A	0.041
HK2	hexokinase 2	0.033
BMP4	bone morphogenetic protein 4	0.032
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.030
HDAC6	histone deacetylase 6	0.030
CHRDL1	chordin-like 1	0.029
GPC4	glypican 4	0.029
INHBB	inhibin, beta B	0.029
FZD7	frizzled homolog 7 (Drosophila)	0.028	Human
PLXDC1	plexin domain containing 1	0.027
FGF8	fibroblast growth factor 8 (androgen-induced)	0.027
BMP7	bone morphogenetic protein 7	0.026
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.026
SOX9	SRY (sex determining region Y)-box 9	0.026
CXCL14	chemokine (C-X-C motif) ligand 14	0.025
LMO4	LIM domain only 4	0.024
CSNK1E	casein kinase 1, epsilon	0.024
OMD	osteomodulin	0.024
SIM2	single-minded homolog 2 (Drosophila)	0.023
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.022
COMP	cartilage oligomeric matrix protein	0.021
MSX1	msh homeobox 1	0.021
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.021
LMOD1	leiomodin 1 (smooth muscle)	0.020
OLFML1	olfactomedin-like 1	0.020
FRZB	frizzled-related protein	0.020	Human
WIF1	WNT inhibitory factor 1	0.020
LRRC17	leucine rich repeat containing 17	0.020
SFRP2	secreted frizzled-related protein 2	0.020
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.020
RAI2	retinoic acid induced 2	0.019
PPAP2B	phosphatidic acid phosphatase type 2B	0.019
MN1	meningioma (disrupted in balanced translocation) 1	0.018
C19orf46	chromosome 19 open reading frame 46	0.018
ASPN	asporin	0.018
ITGA8	integrin, alpha 8	0.017
FOXF1	forkhead box F1	0.017
C7	complement component 7	0.017
BBS7	Bardet-Biedl syndrome 7	0.017
ZNF746	zinc finger protein 746	0.017
PTK2	PTK2 protein tyrosine kinase 2	0.017
SCUBE2	signal peptide, CUB domain, EGF-like 2	0.016
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.016
TBX2	T-box 2	0.016
PERP	PERP, TP53 apoptosis effector	0.016
ROR1	receptor tyrosine kinase-like orphan receptor 1	0.016
WNT3	wingless-type MMTV integration site family, member 3	0.015
PIP4K2B	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	0.015
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.015
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.015
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.015
PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha	0.014
C10orf116	chromosome 10 open reading frame 116	0.014
ZNF423	zinc finger protein 423	0.014
TWIST1	twist homolog 1 (Drosophila)	0.014
JAG1	jagged 1	0.014
LAMA2	laminin, alpha 2	0.014
FZD8	frizzled homolog 8 (Drosophila)	0.014	Human
SOX17	SRY (sex determining region Y)-box 17	0.014
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.014
ZCCHC24	zinc finger, CCHC domain containing 24	0.014
SPAG1	sperm associated antigen 1	0.014
FLRT2	fibronectin leucine rich transmembrane protein 2	0.013
WISP1	WNT1 inducible signaling pathway protein 1	0.013
SHISA2	shisa homolog 2 (Xenopus laevis)	0.013
PENK	proenkephalin	0.013
COL4A1	collagen, type IV, alpha 1	0.013
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.013
KCNS3	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	0.013
DCN	decorin	0.012
COL4A6	collagen, type IV, alpha 6	0.012
ITIH5	inter-alpha (globulin) inhibitor H5	0.012
C8orf84	chromosome 8 open reading frame 84	0.012
CRLF1	cytokine receptor-like factor 1	0.012
TRIL	TLR4 interactor with leucine-rich repeats	0.012
SP5	Sp5 transcription factor	0.012
BMP2	bone morphogenetic protein 2	0.012
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.012
AXIN2	axin 2	0.012
ADRA2A	adrenergic, alpha-2A-, receptor	0.012
RGS5	regulator of G-protein signaling 5	0.012
PCDH8	protocadherin 8	0.012
ANGPT1	angiopoietin 1	0.011
TSPAN12	tetraspanin 12	0.011
COL21A1	collagen, type XXI, alpha 1	0.011
FOXQ1	forkhead box Q1	0.011
LRP4	low density lipoprotein receptor-related protein 4	0.011
PCSK5	proprotein convertase subtilisin/kexin type 5	0.011
OLIG2	oligodendrocyte lineage transcription factor 2	0.011
RAB23	RAB23, member RAS oncogene family	0.011
SYNPO2	synaptopodin 2	0.011
BFSP1	beaded filament structural protein 1, filensin	0.011
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.011
OSR2	odd-skipped related 2 (Drosophila)	0.010
MATN2	matrilin 2	0.010
DSG2	desmoglein 2	0.010
LEPREL4	leprecan-like 4	0.010
COLEC12	collectin sub-family member 12	0.010
IGF1	insulin-like growth factor 1 (somatomedin C)	0.010
SPON1	spondin 1, extracellular matrix protein	0.010
TRIM32	tripartite motif containing 32	0.010
SOSTDC1	sclerostin domain containing 1	0.010
BBS12	Bardet-Biedl syndrome 12	0.010
EFHD1	EF-hand domain family, member D1	0.010