IMP
Process View
rig i signaling pathway
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.
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Click on a gene's description to view its network relationships with genes known to be involved in "rig i signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| IFI44 | interferon-induced protein 44 | 0.640 | ||
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.557 | ||
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.464 | ||
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.444 | ||
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.284 | ||
| IFIH1 | interferon induced with helicase C domain 1 | 0.170 | Human | |
| SP110 | SP110 nuclear body protein | 0.153 | ||
| DTX3L | deltex 3-like (Drosophila) | 0.134 | ||
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.088 | ||
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.085 | ||
| OAS1 | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 0.078 | ||
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 0.075 | ||
| SAMD9 | sterile alpha motif domain containing 9 | 0.072 | ||
| SP100 | SP100 nuclear antigen | 0.067 | ||
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.048 | ||
| IRF9 | interferon regulatory factor 9 | 0.047 | ||
| NMI | N-myc (and STAT) interactor | 0.044 | ||
| ISG15 | ISG15 ubiquitin-like modifier | 0.033 | ||
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.029 | ||
| IFI35 | interferon-induced protein 35 | 0.022 | ||
| PLSCR1 | phospholipid scramblase 1 | 0.021 | ||
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.021 | ||
| MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.020 | ||
| SAMD9L | sterile alpha motif domain containing 9-like | 0.018 | ||
| IFI44L | interferon-induced protein 44-like | 0.017 | ||
| TRIM5 | tripartite motif containing 5 | 0.016 | Human | |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.014 | ||
| TDRD7 | tudor domain containing 7 | 0.013 | ||
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.013 | ||
| TRIM25 | tripartite motif containing 25 | 0.013 | ||
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.012 | ||
| HERC5 | hect domain and RLD 5 | 0.011 | ||
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.010 | Human |