IMP

Process View

Homo sapiens

15 genes annotated in human

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hormone secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC2	histone deacetylase 2	0.608
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.548	Fly
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.545
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.357
ADORA2A	adenosine A2a receptor	0.298
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.266
LIN7B	lin-7 homolog B (C. elegans)	0.264
MPDZ	multiple PDZ domain protein	0.259
MED15	mediator complex subunit 15	0.254
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.243	Rat
CRHR1	corticotropin releasing hormone receptor 1	0.232	Rat
CRH	corticotropin releasing hormone	0.140	Rat
IL1R1	interleukin 1 receptor, type I	0.129
GRB10	growth factor receptor-bound protein 10	0.124
SIRT1	sirtuin 1	0.099
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.068
VAC14	Vac14 homolog (S. cerevisiae)	0.062
BMPR1B	bone morphogenetic protein receptor, type IB	0.061
ZNF746	zinc finger protein 746	0.060
IL6R	interleukin 6 receptor	0.060
IRS1	insulin receptor substrate 1	0.056
DLG4	discs, large homolog 4 (Drosophila)	0.056
INSR	insulin receptor	0.050
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.049
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.047
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.047
IGF1R	insulin-like growth factor 1 receptor	0.041
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.036	Rat
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.035
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.033
NSF	N-ethylmaleimide-sensitive factor	0.031
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.031
PTEN	phosphatase and tensin homolog	0.023
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.023
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.023
GAB1	GRB2-associated binding protein 1	0.023
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.022
IL1RAP	interleukin 1 receptor accessory protein	0.020
RBBP7	retinoblastoma binding protein 7	0.020
BMP8A	bone morphogenetic protein 8a	0.019
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.018
IL8	interleukin 8	0.018
PINK1	PTEN induced putative kinase 1	0.018
FRS2	fibroblast growth factor receptor substrate 2	0.018
GJD2	gap junction protein, delta 2, 36kDa	0.017
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.016
FGF18	fibroblast growth factor 18	0.016
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.016
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.016	Human
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.015
NOG	noggin	0.015
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.015	Human
KCNJ16	potassium inwardly-rectifying channel, subfamily J, member 16	0.015	Human
ACAN	aggrecan	0.015
KRTAP4-12	keratin associated protein 4-12	0.014
SH2B1	SH2B adaptor protein 1	0.014
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.013
LIFR	leukemia inhibitory factor receptor alpha	0.013
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.013
MAGEA11	melanoma antigen family A, 11	0.013
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.013
PDCD2	programmed cell death 2	0.013
RCOR1	REST corepressor 1	0.012
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.012
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.012
WNT2	wingless-type MMTV integration site family member 2	0.012
MTNR1A	melatonin receptor 1A	0.011
GPR6	G protein-coupled receptor 6	0.011
SCTR	secretin receptor	0.011
COL2A1	collagen, type II, alpha 1	0.011
FOXO3	forkhead box O3	0.011
IL1RN	interleukin 1 receptor antagonist	0.011
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.011
FST	follistatin	0.010
PTPRN	protein tyrosine phosphatase, receptor type, N	0.010