IMP
Process View
nuclear transcribed mrna catabolic process nonsense mediated decay
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nuclear transcribed mrna catabolic process nonsense mediated decay"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RBM8A | RNA binding motif protein 8A | 1.000 | ||
| UPF1 | UPF1 regulator of nonsense transcripts homolog (yeast) | 1.000 | ||
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | 1.000 | ||
| SMG1 | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | 0.999 | ||
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.997 | ||
| DCP1A | DCP1 decapping enzyme homolog A (S. cerevisiae) | 0.971 | ||
| MAGOH | mago-nashi homolog, proliferation-associated (Drosophila) | 0.966 | ||
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | 0.947 | Human Worm | |
| EXOSC3 | exosome component 3 | 0.907 | ||
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.539 | ||
| THOC4 | THO complex 4 | 0.440 | ||
| NCBP1 | nuclear cap binding protein subunit 1, 80kDa | 0.395 | ||
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.337 | ||
| NCBP2 | nuclear cap binding protein subunit 2, 20kDa | 0.298 | ||
| C19orf61 | chromosome 19 open reading frame 61 | 0.280 | ||
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | 0.217 | Yeast | |
| DIS3L | DIS3 mitotic control homolog (S. cerevisiae)-like | 0.185 | ||
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.173 | ||
| NCOA2 | nuclear receptor coactivator 2 | 0.160 | ||
| TERT | telomerase reverse transcriptase | 0.117 | ||
| TARDBP | TAR DNA binding protein | 0.116 | ||
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.079 | ||
| EIF3F | eukaryotic translation initiation factor 3, subunit F | 0.071 | ||
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.062 | ||
| C17orf85 | chromosome 17 open reading frame 85 | 0.062 | ||
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 0.055 | Yeast | |
| RBMX | RNA binding motif protein, X-linked | 0.054 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.051 | ||
| SMG7 | Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) | 0.050 | Human | |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | 0.048 | ||
| C17orf71 | chromosome 17 open reading frame 71 | 0.046 | ||
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.040 | ||
| SRPK2 | SRSF protein kinase 2 | 0.033 | ||
| STAU1 | staufen, RNA binding protein, homolog 1 (Drosophila) | 0.032 | ||
| EXOSC10 | exosome component 10 | 0.032 | ||
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.030 | ||
| SF1 | splicing factor 1 | 0.029 | ||
| C5orf41 | chromosome 5 open reading frame 41 | 0.029 | ||
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.028 | ||
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.026 | ||
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 0.024 | Human | |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.023 | ||
| POLDIP3 | polymerase (DNA-directed), delta interacting protein 3 | 0.023 | ||
| RBM4 | RNA binding motif protein 4 | 0.023 | ||
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.022 | ||
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.022 | ||
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.022 | ||
| CASC3 | cancer susceptibility candidate 3 | 0.021 | ||
| EIF3M | eukaryotic translation initiation factor 3, subunit M | 0.021 | ||
| FBXO33 | F-box protein 33 | 0.020 | ||
| MPHOSPH6 | M-phase phosphoprotein 6 | 0.018 | ||
| RPL11 | ribosomal protein L11 | 0.017 | ||
| ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 | 0.016 | ||
| XRN2 | 5'-3' exoribonuclease 2 | 0.015 | ||
| GSPT2 | G1 to S phase transition 2 | 0.015 | ||
| PCBP2 | poly(rC) binding protein 2 | 0.015 | ||
| ACD | adrenocortical dysplasia homolog (mouse) | 0.015 | ||
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.014 | ||
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 0.013 | ||
| PPP1R16A | protein phosphatase 1, regulatory (inhibitor) subunit 16A | 0.013 | ||
| DOM3Z | dom-3 homolog Z (C. elegans) | 0.013 | ||
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.013 | ||
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.012 | ||
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.012 | ||
| TNRC6C | trinucleotide repeat containing 6C | 0.012 | ||
| HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H') | 0.012 | ||
| SRSF9 | serine/arginine-rich splicing factor 9 | 0.011 | ||
| EXOSC1 | exosome component 1 | 0.011 | ||
| RC3H2 | ring finger and CCCH-type domains 2 | 0.011 | ||
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.011 | ||
| EIF3L | eukaryotic translation initiation factor 3, subunit L | 0.011 | ||
| GLOD4 | glyoxalase domain containing 4 | 0.011 | ||
| MAGOHB | mago-nashi homolog B (Drosophila) | 0.010 | Human | |
| SRPK1 | SRSF protein kinase 1 | 0.010 | ||
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 0.010 |