IMP

Process View

Mus musculus

13 genes annotated in mouse

regulation of inhibitory postsynaptic membrane potential

Any process that modulates the establishment or extent of the inhibitory postsynaptic potential (IPSP) which is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of inhibitory postsynaptic membrane potential"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of inhibitory postsynaptic membrane potential" (in gray)

Name	Description	Probability	Func Analog Organism
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.914	Mouse
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.821
Dlg4	discs, large homolog 4 (Drosophila)	0.666
Grid1	glutamate receptor, ionotropic, delta 1	0.454
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.230
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.214
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.183	Mouse
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.179	Mouse
Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	0.149	Mouse
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.142	Mouse
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.113	Mouse
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.091	Mouse
Gad2	glutamic acid decarboxylase 2	0.063
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.058
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	0.051	Mouse
Nxph1	neurexophilin 1	0.048
Pcdh10	protocadherin 10	0.046
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.040
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.036	Mouse
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	0.036
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.033
Cdh8	cadherin 8	0.033
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.033
Syt1	synaptotagmin I	0.032
Rit2	Ras-like without CAAX 2	0.031
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.031	Mouse
Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	0.029	Mouse
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.028	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.027
Adcyap1	adenylate cyclase activating polypeptide 1	0.027
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.025
Glra1	glycine receptor, alpha 1 subunit	0.023
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.023
Nrg1	neuregulin 1	0.023
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.022	Mouse
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.022
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.022
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.021	Mouse
Pgr	progesterone receptor	0.020
Epha5	Eph receptor A5	0.019
Cnr1	cannabinoid receptor 1 (brain)	0.019
Dcc	deleted in colorectal carcinoma	0.019
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.018
Nrg3	neuregulin 3	0.018
Kcnk4	potassium channel, subfamily K, member 4	0.017
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.017
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.016
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.016
Cntn4	contactin 4	0.016
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.016
Grik1	glutamate receptor, ionotropic, kainate 1	0.016
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.016
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.015
Dcx	doublecortin	0.015
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.015
Fgf14	fibroblast growth factor 14	0.015
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.015
Grik4	glutamate receptor, ionotropic, kainate 4	0.015	Mouse
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.014
Slc12a5	solute carrier family 12, member 5	0.014
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.014
Cdh9	cadherin 9	0.014
Grip1	glutamate receptor interacting protein 1	0.014
Pclo	piccolo (presynaptic cytomatrix protein)	0.014
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.014	Mouse
Stx1b	syntaxin 1B	0.014
Otx2	orthodenticle homolog 2 (Drosophila)	0.013
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.013
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.013
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.013
Cntn2	contactin 2	0.013
Scn1a	sodium channel, voltage-gated, type I, alpha	0.013
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.013
Musk	muscle, skeletal, receptor tyrosine kinase	0.012
Ncam2	neural cell adhesion molecule 2	0.012
Grm8	glutamate receptor, metabotropic 8	0.012
Fbxl20	F-box and leucine-rich repeat protein 20	0.012
Gpr12	G-protein coupled receptor 12	0.012
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.012
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.012
Gjd2	gap junction protein, delta 2	0.012
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.012
Mas1	MAS1 oncogene	0.012
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.012
Plp1	proteolipid protein (myelin) 1	0.012
Gsbs	G substrate	0.011
Oprk1	opioid receptor, kappa 1	0.011
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.011
Esrrb	estrogen related receptor, beta	0.011
Npy2r	neuropeptide Y receptor Y2	0.011
Mmp16	matrix metallopeptidase 16	0.011
Mgat4c	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	0.011
Grpr	gastrin releasing peptide receptor	0.011
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.011
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.011
Vti1a	vesicle transport through interaction with t-SNAREs homolog 1A (yeast)	0.011
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.011
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.011
St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	0.011
Has1	hyaluronan synthase1	0.011
Npas1	neuronal PAS domain protein 1	0.010
Oprm1	opioid receptor, mu 1	0.010
Zic3	zinc finger protein of the cerebellum 3	0.010
Gria3	glutamate receptor, ionotropic, AMPA3 (alpha 3)	0.010	Mouse
Alk	anaplastic lymphoma kinase	0.010
Nrsn1	neurensin 1	0.010
Rorb	RAR-related orphan receptor beta	0.010
Gabra5	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5	0.010	Mouse
Slitrk1	SLIT and NTRK-like family, member 1	0.010
Grik3	glutamate receptor, ionotropic, kainate 3	0.010	Mouse
Odz1	odd Oz/ten-m homolog 1 (Drosophila)	0.010
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.010
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.010
Cckbr	cholecystokinin B receptor	0.010
Vip	vasoactive intestinal polypeptide	0.010
Drd2	dopamine receptor D2	0.010	Mouse